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CAS 814-68-6
acryloyl chloride2-Propenoyl chlorideAcryloyl chloride2-Propenoyl chloride; Acrylic acid chloride; Acrylic chloride; Acryloyl chloride
登记编号：OSIM-010、IBRT-008、(IX)461018-2-a、(IV)461018-6-a、(IX)461018-8-a、(XI)461018-10-a、(X)461018-11-a、(VII)461018-17-a、(X)461018-20-a、(IV)461018-21-a、(XI)461018-25-a、(XII)461018-28-a 等 24 个
应用背景（按来源药适应症）
非小细胞肺癌甲磺酸奥希替尼华氏巨球蛋白血症伊布替尼慢性淋巴细胞白血病伊布替尼套细胞淋巴瘤伊布替尼移植物抗宿主病伊布替尼非小细胞肺癌奥莫替尼HIV感染乙醇达芦那韦/利托那韦HIV感染乙醇达芦那韦/考比司他HIV感染乙醇达芦那韦非小细胞肺癌氟泽雷塞结直肠癌氟泽雷塞实体瘤氟泽雷塞非小细胞肺癌甲磺酸兰泽替尼肝功能衰退甲磺酸兰泽替尼边缘带B细胞淋巴瘤奥布替尼套细胞淋巴瘤奥布替尼慢性淋巴细胞白血病奥布替尼特发性血小板减少性紫癜奥布替尼系统性红斑狼疮奥布替尼多发性硬化奥布替尼非小细胞肺癌宗艾替尼肺癌宗艾替尼食道腺癌宗艾替尼食管胃结合部肿瘤宗艾替尼胃癌宗艾替尼转移性乳腺癌宗艾替尼非小细胞肺癌格索雷塞结直肠癌格索雷塞实体瘤格索雷塞肾细胞癌格索雷塞胰腺癌格索雷塞非小细胞肺癌舒沃替尼B-细胞淋巴瘤舒沃替尼非霍奇金淋巴瘤舒沃替尼非小细胞肺癌马来酸艾维替尼非霍奇金淋巴瘤马来酸艾维替尼淋巴瘤马来酸艾维替尼慢性淋巴细胞白血病马来酸艾维替尼弥漫性大B-细胞淋巴瘤马来酸艾维替尼套细胞淋巴瘤马来酸艾维替尼
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 甲磺酸奥希替尼Osimertinib Mesylate | Tier A · 立即攻坚 | 2031 |
| 伊布替尼Ibrutinib | Tier A · 立即攻坚 | 2027 |
| 奥莫替尼Olmutinib | Tier C · 观察 / 贸易 | - |
| 乙醇达芦那韦/利托那韦Darunavir Ethanolate/Ritonavir | Tier C · 观察 / 贸易 | - |
| 乙醇达芦那韦/考比司他Darunavir Ethanolate/Cobicistat | Tier C · 观察 / 贸易 | - |
| 乙醇达芦那韦Darunavir Ethanolate | Tier B · 提前布局 | - |
| 氟泽雷塞Fulzerasib | Tier C · 观察 / 贸易 | - |
| 甲磺酸兰泽替尼Lazertinib Mesylate | Tier C · 观察 / 贸易 | - |
| 奥布替尼Orelabrutinib | Tier C · 观察 / 贸易 | - |
| 宗艾替尼Zongertinib | Tier C · 观察 / 贸易 | - |
| 格索雷塞Garsorasib | Tier C · 观察 / 贸易 | - |
| 舒沃替尼Sunvozertinib | Tier C · 观察 / 贸易 | - |
| 马来酸艾维替尼Abivertinib | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1H-indole→2,4-dichloropyrimidine→3-(2-chloropyrimidin-4-yl)-1H-indole→3-(2-chloropyrimidin-4-yl)-1-methyl-1H-indole→4-fluoro-2-methoxy-5-nitroaniline→N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine→N1,N1,N2-trimethylethane-1,2-diamine→N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine→N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine→acryloyl chloride→methanesulfonic acid
3-(2-chloropyrimidin-4-yl)-1-methyl-1H-indole→4-fluoro-2-methoxy-5-nitroaniline→N1,N1,N2-trimethylethane-1,2-diamine→acryloyl chloride→tert-butyl (4-fluoro-2-methoxy-5-nitrophenyl)carbamate→tert-butyl (4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxy-5-nitrophenyl)carbamate→tert-butyl (5-amino-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenyl)carbamate→N-(5-amino-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
N1,N1,N2-trimethylethane-1,2-diamine→acryloyl chloride→N-(5-amino-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide→2-fluoro-4-iodoaniline→hexane-2,5-dione→1-(2-fluoro-4-iodophenyl)-2,5-dimethyl-1H-pyrrole→1-(2-fluoro-4-methoxyphenyl)-2,5-dimethyl-1H-pyrrole→2-fluoro-4-methoxyaniline→N-(2-fluoro-4-methoxyphenyl)acrylamide→N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide→N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-nitrophenyl)acrylamide→N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-guanidino-4-methoxyphenyl)acrylamide→(E)-3-(dimethylamino)-1-(1-methyl-1H-indol-3-yl)prop-2-en-1-one→1-(1-methyl-1H-indol-3-yl)ethanone
4-phenoxybenzoic acid→2-(hydroxy(4-phenoxyphenyl)methylene)malononitrile→2-(methoxy(4-phenoxyphenyl)methylene)malononitrile→5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile→3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→(S)-tert-butyl 3-hydroxypiperidine-1-carboxylate→(R)-tert-butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate→acryloyl chloride→1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→tert-butyl 4-(((6-amino-5-chloropyrimidin-4-yl)amino)methyl)piperidine-1-carboxylate
3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→(4-Phenoxyphenyl)boranediol→3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→N-Boc-3(S)-Hydroxypiperidine→2-Propenoyl chloride→(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester→Perfluoroacetyl chloride→tert-Butyl (3R)-3-[3-(4-phenoxyphenyl)-4-[(trifluoroacetyl)amino]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate→2,2,2-Trifluoro-N-[3-(4-phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]acetamide→N-[1-[(3R)-1-Acryloylpiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-2,2,2-trifluoroacetamide
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