CAS 98-80-6

phenylboronic acid

登记编号：PERAM-004、RITO-009、Sertraline Hydrochloride-129、Rilza-011

应用背景（按来源药适应症）

强直阵挛性癫痫吡仑帕奈癫痫部分性发作吡仑帕奈癫痫吡仑帕奈癫痫发作吡仑帕奈慢性丙型肝炎帕利普韦/奥比他韦/利托那韦丙型肝炎帕利普韦/奥比他韦/利托那韦失代偿性肝硬化帕利普韦/奥比他韦/利托那韦肾功能不全帕利普韦/奥比他韦/利托那韦纤维化帕利普韦/奥比他韦/利托那韦终末期肾脏病帕利普韦/奥比他韦/利托那韦HIV感染乙醇达芦那韦/利托那韦强迫性障碍枸橼酸舍曲林HIV感染利托那韦卡波济氏肉瘤利托那韦乳腺癌利托那韦特发性血小板减少性紫癜利扎布替尼免疫球蛋白G4相关疾病利扎布替尼自身免疫性溶血性贫血利扎布替尼镰状细胞血症利扎布替尼格雷夫斯病利扎布替尼哮喘利扎布替尼

来源药（使用该中间体的合成路线）

品种	梯队	到期年
吡仑帕奈Perampanel Hydrate	Tier C · 观察 / 贸易	2028
帕利普韦/奥比他韦/利托那韦Paritaprevir/Ombitasvir/Ritonavir	Tier C · 观察 / 贸易	-
乙醇达芦那韦/利托那韦Darunavir Ethanolate/Ritonavir	Tier C · 观察 / 贸易	-
枸橼酸舍曲林Sertraline Citrate	Tier C · 观察 / 贸易	-
利托那韦Ritonavir	Tier C · 观察 / 贸易	-
利扎布替尼Rilzabrutinib	Tier C · 观察 / 贸易	-

合成路线中的位置（上下游链）

按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。

吡仑帕奈原研路线步数：6总收率：/

5-bromopyridin-2-amine→5-bromo-3-iodopyridin-2-amine→5-bromo-3-iodopyridin-2(1H)-one→phenylboronic acid→5-bromo-3-iodo-1-phenylpyridin-2(1H)-one→2-(1,3,2-dioxaborinan-2-yl)benzonitrile→2-(5-bromo-2-oxo-1-phenyl-1,2-dihydropyridin-3-yl)benzonitrile→2-(2-oxo-1-phenyl-5-(tributylstannyl)-1,2-dihydropyridin-3-yl)benzonitrile→2-chloropyridine

吡仑帕奈优化路线步数：8总收率：0.06 g

phenylboronic acid→2-(1,3,2-dioxaborinan-2-yl)benzonitrile→2,5-dibromopyridine→5-bromo-2-methoxypyridine→2-(tributylstannyl)pyridine→6'-methoxy-2,3'-bipyridine→[2,3'-bipyridin]-6'(1'H)-one→5'-bromo-[2,3'-bipyridin]-6'(1'H)-one→5'-bromo-6'-methoxy-2,3'-bipyridine→2-(6'-methoxy-[2,3'-bipyridin]-5'-yl)benzonitrile→2-(6'-oxo-1',6'-dihydro-[2,3'-bipyridin]-5'-yl)benzonitrile

吡仑帕奈优化路线步数：5总收率：62.8 g

5-acetyl-1-phenylpyridin-2(1H)-one→5-acetyl-3-bromo-1-phenylpyridin-2(1H)-one→2-(1,3,2-dioxaborolan-2-yl)benzonitrile→2-(5-acetyl-2-oxo-1-phenyl-1,2-dihydropyridin-3-yl)benzonitrile→(E)-3-(dimethylamino)acrylaldehyde→phenylboronic acid→1-(6-chloropyridin-3-yl)ethanone→5-acetylpyridin-2(1H)-one

帕利普韦/奥比他韦/利托那韦原研路线步数：9总收率：100.00 mg

(S)-benzyl (1-hydroxy-3-phenylpropan-2-yl)carbamate→(S)-benzyl (1-oxo-3-phenylpropan-2-yl)carbamate→dibenzyl ((2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate→1-bromo-2-methyl-1-oxopropan-2-yl acetate→(5S,6R,7R,8S)-5,8-dibenzyl-7-bromo-3,10-dioxo-1,12-diphenyl-2,11-dioxa-4,9-diazadodecan-6-yl acetate→dibenzyl ((1S,1'S)-((2R,3R)-oxirane-2,3-diyl)bis(2-phenylethane-1,1-diyl))dicarbamate→dibenzyl ((2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate→(2S,3S,5S)-2,5-diamino-1,6-diphenylhexan-3-ol→phenylboronic acid→(S)-1-((4S,6S)-4-benzyl-2-phenyl-1,3,2-oxazaborinan-6-yl)-2-phenylethanamine→4-nitrophenyl (thiazol-5-ylmethyl) carbonate→thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate→(S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid→ethyl 2-chloroacetate→ethyl 2-chloro-3-oxopropanoate→methanethioamide→ethyl thiazole-5-carboxylate→thiazol-5-ylmethanol→4-nitrophenyl carbonochloridate→isobutyramide→2-methylpropanethioamide→1,3-dichloropropan-2-one→methyl L-valinate hydrochloride→1-(2-isopropylthiazol-4-yl)-N-methylmethanamine→RITO-025→(S)-methyl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoate

乙醇达芦那韦/利托那韦原研路线步数：9总收率：100.00 mg

本站可供应的对应中间体

同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。

供应商	产品	价格区间	最小起订	货期	资质
Qualified Partner — East China API Works	(2-fluoro-4-phenoxyphenyl)boronic acid Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	Benzyl 4-(oxetan-3-yl)piperazine-1-carboxylate Pharmaceutical Intermediates	询价	询价	询价	—

本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。