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CAS 624-28-2
2,5-dibromopyridine
登记编号：PERAM-010、TEDI-009、BEBT-908-012、PRAD-008
应用背景（按来源药适应症）
强直阵挛性癫痫吡仑帕奈癫痫部分性发作吡仑帕奈癫痫吡仑帕奈癫痫发作吡仑帕奈皮肤和皮肤结构感染泰地唑利磷酸盐葡萄球菌感染泰地唑利磷酸盐细菌性皮肤疾病泰地唑利磷酸盐弥漫性大B-细胞淋巴瘤盐酸伊吡诺司他大B细胞淋巴瘤盐酸伊吡诺司他外周T细胞淋巴瘤盐酸伊吡诺司他非小细胞肺癌盐酸伊吡诺司他乳腺癌盐酸伊吡诺司他转移性乳腺癌盐酸伊吡诺司他便秘PradigastatI型高脂蛋白血症Pradigastat高甘油三酯血症Pradigastat冠状动脉病变Pradigastat丙型肝炎Pradigastat非酒精性脂肪性肝炎Pradigastat
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 吡仑帕奈Perampanel Hydrate | Tier C · 观察 / 贸易 | 2028 |
| 泰地唑利磷酸盐Tedizolid Phosphate | Tier C · 观察 / 贸易 | 2029 |
| 盐酸伊吡诺司他Ifupinostat Hydrochloride | Tier C · 观察 / 贸易 | - |
| Pradigastat | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
phenylboronic acid→2-(1,3,2-dioxaborinan-2-yl)benzonitrile→2,5-dibromopyridine→5-bromo-2-methoxypyridine→2-(tributylstannyl)pyridine→6'-methoxy-2,3'-bipyridine→[2,3'-bipyridin]-6'(1'H)-one→5'-bromo-[2,3'-bipyridin]-6'(1'H)-one→5'-bromo-6'-methoxy-2,3'-bipyridine→2-(6'-methoxy-[2,3'-bipyridin]-5'-yl)benzonitrile→2-(6'-oxo-1',6'-dihydro-[2,3'-bipyridin]-5'-yl)benzonitrile
3-fluoroaniline→benzyl (3-fluorophenyl)carbamate→(R)-oxiran-2-ylmethyl butyrate→(R)-3-(3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one→(R)-3-(3-fluoro-4-iodophenyl)-5-(hydroxymethyl)oxazolidin-2-one→(R)-3-(3-fluoro-4-(tributylstannyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one→5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine→(R)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one→2,5-dibromopyridine→(5-(methylsulfonyl)pyridin-2-yl)methanamine hydrochloride→5-bromo-2-(2H-tetrazol-5-yl)pyridine
N-hydroxy-2-(methyl((2-(6-(methylamino)pyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)amino)pyrimidine-5-carboxamide trihydrochloride→methyl 3-aminothiophene-2-carboxylate→thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione→2,4-dichlorothieno[3,2-d]pyrimidine→4-(2-chlorothieno[3,2-d]pyrimidin-4-yl)morpholine→2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde→1-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-methylmethanamine→ethyl 2-chloropyrimidine-5-carboxylate→ethyl 2-(((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate→(6-(methylamino)pyridin-3-yl)boronic acid hydrochloride→ethyl 2-(methyl((2-(6-(methylamino)pyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)amino)pyrimidine-5-carboxylate→N-hydroxy-2-(methyl((2-(6-(methylamino)pyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)amino)pyrimidine-5-carboxamide→2,5-dibromopyridine→5-bromo-N-methylpyridin-2-amine→tert-butyl (5-bromopyridin-2-yl)(methyl)carbamate
4-(4-hydroxyphenyl)cyclohexan-1-one→methyl 2-(dimethoxyphosphoryl)acetate→methyl 2-(4-(4-hydroxyphenyl)cyclohexylidene)acetate→methyl 2-((1r,4r)-4-(4-hydroxyphenyl)cyclohexyl)acetate→methyl 2-((1r,4r)-4-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)cyclohexyl)acetate→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→methyl 2-((1r,4r)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclohexyl)acetate→2,5-dibromopyridine→methyl 2-((1r,4r)-4-(4-(5-bromopyridin-2-yl)phenyl)cyclohexyl)acetate→6-(trifluoromethyl)pyridin-3-amine→methyl 2-((1r,4r)-4-(4-(5-((6-(trifluoromethyl)pyridin-3-yl)amino)pyridin-2-yl)phenyl)cyclohexyl)acetate
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