Carotegrast methyl
Tier C — Watch / tradeCarotegrast methyl
Targets：ITGA4&ITGB1, ITGA4&ITGB7
Brand：Carogra
Indications (approved)：Ulcerative colitis
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| CAROM-001 | 949-99-5 | (S)-2-amino-3-(4-nitrophenyl)propanoic acid |
| CAROM-002 | 4659-45-4 | 2,6-dichlorobenzoyl chloride |
| CAROM-003 | 401906-14-7 | (S)-2-(2,6-dichlorobenzamido)-3-(4-nitrophenyl)propanoic acid |
| CAROM-004 | - | methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-nitrophenyl)propanoate |
| CAROM-005 | - | methyl (S)-3-(4-aminophenyl)-2-(2,6-dichlorobenzamido)propanoate |
| CAROM-006 | 749863-28-3 | methyl 2-amino-5-(dimethylamino)benzoate dihydrochloride |
| CAROM-007 | 749863-30-7 | methyl (S)-2-(3-(4-(2-(2,6-dichlorobenzamido)-3-methoxy-3-oxopropyl)phenyl)ureido)-5-(dimethylamino)benzoate |
| CAROM-008 | 749863-31-8 | methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(6-(dimethylamino)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)propanoate |
| CAROM-009 | 2516-95-2 | 5-chloro-2-nitrobenzoic acid |
| CAROM-010 | 62876-66-8 | 5-(dimethylamino)-2-nitrobenzoic acid |
| CAROM-011 | 749863-29-4 | methyl 5-(dimethylamino)-2-nitrobenzoate |
| Code | CAS No. | Intermediate |
|---|---|---|
| CAROM-002 | 4659-45-4 | 2,6-dichlorobenzoyl chloride |
| CAROM-012 | 95753-55-2 | (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid |
| CAROM-013 | - | methyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-nitrophenyl)propanoate |
| CAROM-014 | 81677-60-3 | methyl (S)-2-amino-3-(4-nitrophenyl)propanoate |
| CAROM-015 | - | methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-nitrophenyl)propanoate |
| CAROM-016 | - | methyl (S)-3-(4-aminophenyl)-2-(2,6-dichlorobenzamido)propanoate |
| CAROM-017 | 320-98-9 | 5-fluoro-2-nitrobenzoic acid |
| CAROM-018 | - | methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(5-fluoro-2-nitrobenzamido)phenyl)propanoate |
| CAROM-019 | - | methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(5-(dimethylamino)-2-nitrobenzamido)phenyl)propanoate |
| CAROM-020 | - | methyl (S)-3-(4-(2-amino-5-(dimethylamino)benzamido)phenyl)-2-(2,6-dichlorobenzamido)propanoate |
| CAROM-021 | 749863-31-8 | methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(6-(dimethylamino)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)propanoate |
| CAROM-022 | - | methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(6-(dimethylamino)-1-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)propanoate |
Frequently asked questions
What are the approved indications of Carotegrast methyl?
Approved indications include: Ulcerative colitis.
When does the Carotegrast methyl patent expire?
No public expiry year is available for Carotegrast methyl yet; this page updates once verified.
How many synthesis routes are recorded for Carotegrast methyl?
2 synthesis routes are recorded; the shortest is 9 steps with 25.3 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Carotegrast methyl intermediates?
All intermediates in Carotegrast methyl routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Carotegrast methyl intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-22