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CAS 81677-60-3
methyl (S)-2-amino-3-(4-nitrophenyl)propanoate
Codes: ZOLM-002, CAROM-014
Application context (from source-drug indications)
MigraineZolmitriptanUlcerative colitisCarotegrast methyl
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Zolmitriptan | Tier C — Watch / trade | - |
| Carotegrast methyl | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-2-amino-3-(4-nitrophenyl)propanoic acid→methyl (S)-2-amino-3-(4-nitrophenyl)propanoate→(S)-2-amino-3-(4-nitrophenyl)propan-1-ol→(S)-4-(4-nitrobenzyl)oxazolidin-2-one→(S)-4-(4-aminobenzyl)oxazolidin-2-one→(S)-4-(4-hydrazinylbenzyl)oxazolidin-2-one→4-chloro-1,1-diethoxybutane→(S)-4-((3-(2-aminoethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one
2,6-dichlorobenzoyl chloride→(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid→methyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-nitrophenyl)propanoate→methyl (S)-2-amino-3-(4-nitrophenyl)propanoate→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-nitrophenyl)propanoate→methyl (S)-3-(4-aminophenyl)-2-(2,6-dichlorobenzamido)propanoate→5-fluoro-2-nitrobenzoic acid→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(5-fluoro-2-nitrobenzamido)phenyl)propanoate→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(5-(dimethylamino)-2-nitrobenzamido)phenyl)propanoate→methyl (S)-3-(4-(2-amino-5-(dimethylamino)benzamido)phenyl)-2-(2,6-dichlorobenzamido)propanoate→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(6-(dimethylamino)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)propanoate→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(6-(dimethylamino)-1-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)propanoate
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