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CAS 4659-45-4
2,6-dichlorobenzoyl chloride
Codes: VEMF-019, CAROM-002
Application context (from source-drug indications)
Erdheim-Chester diseaseVemurafenibMelanomaVemurafenibHistiocytosisVemurafenibLangerhans cell histiocytosisVemurafenibNon-Hodgkin lymphomaVemurafenibHepatoblastomaVemurafenibUlcerative colitisCarotegrast methyl
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Vemurafenib | Tier C — Watch / trade | - |
| Carotegrast methyl | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2,6-difluoro-3-(propylsulfonamido)benzoic acid→5-bromo-1H-pyrrolo[2,3-b]pyridine→N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide→(4-chlorophenyl)boronic acid→5-bromopyridin-2-amine→(E)-2-(2-ethoxyvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→5-bromo-3-iodopyridin-2-amine→2,6-dichlorobenzoyl chloride→N-(3-(5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide→N-(3-(5-(4-chlorophenyl)-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
propane-1-sulfonyl chloride→5-bromo-1H-pyrrolo[2,3-b]pyridine→(4-chlorophenyl)boronic acid→2,6-dichlorobenzoyl chloride→N-(3-(5-(4-chlorophenyl)-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide→2,6-difluoro-3-nitrobenzoyl chloride→(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2,6-difluoro-3-nitrophenyl)methanone→(3-amino-2,6-difluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone→(3-(3-amino-2,6-difluorobenzoyl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-1-yl)(2,6-dichlorophenyl)methanone→(3-(3-amino-2,6-difluorobenzoyl)-5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)(2,6-dichlorophenyl)methanone
(S)-2-amino-3-(4-nitrophenyl)propanoic acid→2,6-dichlorobenzoyl chloride→(S)-2-(2,6-dichlorobenzamido)-3-(4-nitrophenyl)propanoic acid→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-nitrophenyl)propanoate→methyl (S)-3-(4-aminophenyl)-2-(2,6-dichlorobenzamido)propanoate→methyl 2-amino-5-(dimethylamino)benzoate dihydrochloride→methyl (S)-2-(3-(4-(2-(2,6-dichlorobenzamido)-3-methoxy-3-oxopropyl)phenyl)ureido)-5-(dimethylamino)benzoate→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(6-(dimethylamino)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)propanoate→5-chloro-2-nitrobenzoic acid→5-(dimethylamino)-2-nitrobenzoic acid→methyl 5-(dimethylamino)-2-nitrobenzoate
2,6-dichlorobenzoyl chloride→(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid→methyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-nitrophenyl)propanoate→methyl (S)-2-amino-3-(4-nitrophenyl)propanoate→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-nitrophenyl)propanoate→methyl (S)-3-(4-aminophenyl)-2-(2,6-dichlorobenzamido)propanoate→5-fluoro-2-nitrobenzoic acid→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(5-fluoro-2-nitrobenzamido)phenyl)propanoate→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(5-(dimethylamino)-2-nitrobenzamido)phenyl)propanoate→methyl (S)-3-(4-(2-amino-5-(dimethylamino)benzamido)phenyl)-2-(2,6-dichlorobenzamido)propanoate→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(6-(dimethylamino)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)propanoate→methyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(6-(dimethylamino)-1-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)propanoate
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