← Back to patent-cliff list
CAS 122-51-0
(Diethoxymethoxy)ethanetriethoxymethane
Codes: (II)461018-27-a, (VIIIa)638294-1-a, (XIV)638294-3-b, (V)638294-4-a, (VIIa)638294-5-a, (VII)638294-6-a, (III)638294-8-a, (VII)638294-9-a, (VI)638294-10-a,(VI)638294-10-b, (VI)638294-11-a, (X)638294-12-a, (VI)638294-13-a +7 more
Application context (from source-drug indications)
Waldenström macroglobulinaemiaIbrutinibChronic lymphocytic leukaemiaIbrutinibMantle cell lymphomaIbrutinibGraft-versus-host diseaseIbrutinibSystolic heart failureFinerenoneDiastolic heart failureFinerenoneHeart failureFinerenoneChronic renal impairmentFinerenoneDiabetic nephropathyFinerenoneType 2 diabetesFinerenoneDyslipidaemiaFenofibrate/SimvastatinHyperlipidaemiaFenofibrate/SimvastatinCardiac and vascular disordersFenofibrate/SimvastatinHypercholesterolaemiaFenofibrate/SimvastatinHyperlipidaemiaSimvastatinMyocardial infarctionSimvastatinDyslipidaemiaSimvastatinHeterozygous familial hypercholesterolaemiaSimvastatinStrokeSimvastatinHypercholesterolaemiaSimvastatinNon-small cell lung cancerSapitinibMetastatic breast cancerSapitinibNeoplasmSapitinibBreast cancerSapitinibOesophageal cancerSapitinibGastric cancerSapitinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ibrutinib | Tier A — Act now | 2027 |
| Finerenone | Tier C — Watch / trade | 2030 |
| Fenofibrate/Simvastatin | Tier C — Watch / trade | - |
| Simvastatin | Tier C — Watch / trade | - |
| Sapitinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,1-Dicyanomethane→(Diethoxymethoxy)ethane→(Ethoxymethylene)malononitrile→N-Boc-3(R)-hydrazinylpiperidine→(4-Phenoxyphenyl)boranediol→tert-Butyl (3R)-3-(5-amino-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate→Amide c1→tert-Butyl (3R)-3-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate→tert-Butyl (3R)-3-(4-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate→(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→1-(1H-Imidazol-1-yl)prop-2-en-1-one→5-Chloro-1-[(prop-2-enoyl)oxy]-1H-benzotriazole
2,2-Dimethyl-6-methyl-1,3-dioxin-4-one→1-Cyano-2-hydroxyethane→2-Cyanoethyl 3-oxobutanoate→2-Methoxy-4-cyanobenzaldehyde→2-Cyanoethyl (2Z)-2-[(4-cyano-2-methoxyphenyl)methylene]-3-oxobutanoate→4-Amino-5-methylpyridin-2(1H)-one→2-Cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→(Diethoxymethoxy)ethane→1,1,1-Triethoxyethane→2-Cyanoethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid→(±)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide→4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,6-naphthyridine-3-carboxamide
4-Amino-5-methylpyridin-2(1H)-one→(±)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide→4-Bromo-2-methoxybenzaldehyde→1-Cyano-2-propanone→4-(4-Bromo-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carbonitrile→(Diethoxymethoxy)ethane→4-(4-Bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carbonitrile→4-(4-Bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide
4-Amino-5-methylpyridin-2(1H)-one→2-Methoxy-4-cyanobenzaldehyde→Carbethoxyacetic ester→Ethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→(Diethoxymethoxy)ethane→Ethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→4-(5-Ethoxy-3-formyl-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-4-yl)-3-methoxybenzonitrile→Ethyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→(5aR,10bS)-2-(2,6-Dimethoxyphenyl)-6,10b-dihydro-4H,5aH-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoridoborate(1-)
2,2-Dimethyl-6-methyl-1,3-dioxin-4-one→(4-Methylphenyl)methyl 3-oxobutanoate→3-Oxobutyric acid benzyl ester→1,1-Dimethylethyl 3-oxobutanoate→Bicyclo[2.2.1]hept-5-en-2-yl 3-oxobutanoate→2-(4-Nitrophenyl)ethyl 3-oxobutanoate→2-Methoxy-4-cyanobenzaldehyde→(4-Methylphenyl)methyl 2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate→2-[(4-Cyano-2-methoxyphenyl)methylene]-3-oxobutanoic acid phenylmethyl ester→tert-Butyl 2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate→Bicyclo[2.2.1]hept-5-en-2-yl 2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate→2-(4-Nitrophenyl)ethyl 2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate→4-Amino-5-methylpyridin-2(1H)-one→(4-Methylphenyl)methyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→Benzyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→tert-Butyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→Bicyclo[2.2.1]hept-5-en-2-yl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→2-(4-Nitrophenyl)ethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→(Diethoxymethoxy)ethane→1,1,1-Triethoxyethane→(4-Methylphenyl)methyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→Benzyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→tert-Butyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→2-(4-Nitrophenyl)ethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→(4-Methylphenyl)methyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→Benzyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→tert-Butyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→Bicyclo[2.2.1]hept-5-en-2-yl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→2-(4-Nitrophenyl)ethyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→(4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid→Benzyl (4S)-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→Bicyclo[2.2.1]hept-5-en-2-yl (4S)-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 4-Bromo-2-methoxybenzaldehyde Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 4-AMino-5-Methylpyridin-2-ol Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 2-chloro-5-methylpyridin-4-amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.