CAS 21962-45-8

4-formyl-3-methoxybenzonitrile2-Methoxy-4-cyanobenzaldehyde

Codes: FINE-002, (IV)638294-1-a,(IV)638294-1-b,(IV)638294-1-c,(IV)638294-1-d,(IV)638294-1-e, (IV)638294-2-a, (V)638294-3-a, (II)638294-4-a, (III)638294-5-a, (III)638294-7-a, (I)638294-9-a, (I)638294-11-a, (VI)638294-12-a, (I)638294-13-a, (I)638294-15-a +5 more

Application context (from source-drug indications)

Systolic heart failureFinerenoneDiastolic heart failureFinerenoneHeart failureFinerenoneChronic renal impairmentFinerenoneDiabetic nephropathyFinerenoneType 2 diabetesFinerenone

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Finerenone	Tier C — Watch / trade	2030

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

FinerenoneOriginator routesteps: 7total yield: /

tert-butyl (E)-3-(4-cyano-2-methoxyphenyl)acrylate→4-formyl-3-methoxybenzonitrile→2-cyanoethyl 3-oxobutanoate→2-cyanoethyl (Z)-2-(4-cyano-2-methoxybenzylidene)-3-oxobutanoate→4-amino-5-methylpyridin-2(1H)-one→2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid→4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide

FinerenoneOptimised routesteps: 7total yield: /

2,2-Dimethyl-6-methyl-1,3-dioxin-4-one→1-Cyano-2-hydroxyethane→2-Cyanoethyl 3-oxobutanoate→2-Methoxy-4-cyanobenzaldehyde→2-Cyanoethyl (2Z)-2-[(4-cyano-2-methoxyphenyl)methylene]-3-oxobutanoate→4-Amino-5-methylpyridin-2(1H)-one→2-Cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate→(Diethoxymethoxy)ethane→1,1,1-Triethoxyethane→2-Cyanoethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate→4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid→(±)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide→4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,6-naphthyridine-3-carboxamide

FinerenoneOptimised routesteps: 4total yield: /

2-Methoxy-4-cyanobenzaldehyde→4-Formyl-2-methoxyphenol→4-Cyano-2-methoxyphenol→4-Cyano-2-methoxyphenyl trifluoromethanesulfonate→1,1-Dimethylethyl 2-propenoate→tert-Butyl (2Z)-3-(4-cyano-2-methoxyphenyl)acrylate→4-Bromo-2-methoxybenzoic acid→2-Methoxy-4-bromobenzoic acid methyl ester→4-Bromo-2-methoxybenzaldehyde

FinerenoneOptimised routesteps: 6total yield: /

2-Methoxy-4-cyanobenzaldehyde→3-Methoxy-4-methylbenzonitrile→4-(Dibromomethyl)-3-methoxybenzonitrile→4-(Bromomethyl)-3-methoxybenzonitrile→1-[(4-Cyano-2-methoxyphenyl)methyl]-1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decan-1-ium bromide→3-Methoxy-4-methylbenzoic acid→3-Methoxy-4-methylbenzoyl chloride→3-Methoxy-4-methylbenzamide

FinerenoneOptimised routesteps: 4total yield: /

2-Methoxy-4-cyanobenzaldehyde→3-Methoxy-4-methylbenzonitrile→3-Carboxyphenol→3-Hydroxybenzamide→3-Cyanophenol→Formaldehyde→4-Cyano-2-hydroxybenzaldehyde→Dimethoxysulfone→Iodomethane→2-Fluoro-4-cyanotoluene→Hydroxymethane→4-Bromo-3-methoxybenzamide→2-Methoxy-4-cyanobromobenzene

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Taizhou GMP-like Site	4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.