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CAS 616-38-6
dimethyl carbonateMethyl carbonateCarbonicaciddimethyldiesterCarbonic acid dimethyl diester
Codes: MACI-003, Bisoprolol-017, PRAL-013, Ioflupane (123I)-007, (IX)992511-1-a
Application context (from source-drug indications)
Pulmonary arterial hypertensionMacitentanPulmonary hypertensionMacitentanChronic diseaseMacitentanChronic thromboembolic pulmonary hypertensionMacitentanThromboembolismMacitentanAngina pectorisMacitentanHypertensionAmlodipine Besylate/Bisoprolol FumarateEssential hypertensionAmlodipine Besylate/Bisoprolol FumaratePeripheral T-cell lymphomaPralatrexateT-cell lymphomaPralatrexateSolid tumourPralatrexateHaematological malignancyPralatrexateB-cell lymphomaPralatrexateCutaneous T-cell lymphomaPralatrexateHypertensionBisoprolol FumarateAngina pectorisBisoprolol FumarateChronic obstructive pulmonary diseaseBisoprolol FumarateCardiac and vascular disordersBisoprolol FumarateAcute coronary syndromeBisoprolol FumarateFastingBisoprolol FumarateLewy body dementiaIoflupane (123I)Diagnostic agentIoflupane (123I)ParkinsonismIoflupane (123I)Alzheimer's diseaseIoflupane (123I)Parkinson's diseaseIoflupane (123I)DementiaIoflupane (123I)Chronic lymphocytic leukaemiaLisaftoclaxAcute promyelocytic leukaemiaLisaftoclaxMyelodysplastic syndromeLisaftoclaxAcute myeloid leukaemiaLisaftoclaxDiffuse large B-cell lymphomaLisaftoclaxSystemic lupus erythematosusLisaftoclax
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Macitentan | Tier B — Position early | - |
| Amlodipine Besylate/Bisoprolol Fumarate | Tier C — Watch / trade | - |
| Pralatrexate | Tier C — Watch / trade | - |
| Bisoprolol Fumarate | Tier C — Watch / trade | - |
| Ioflupane (123I) | Tier C — Watch / trade | - |
| Lisaftoclax | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(4-bromophenyl)acetic acid→methyl 2-(4-bromophenyl)acetate→dimethyl carbonate→dimethyl 2-(4-bromophenyl)malonate→formimidamide hydrochloride→5-(4-bromophenyl)pyrimidine-4,6-diol→5-(4-bromophenyl)-4,6-dichloropyrimidine→potassium (N-propylsulfamoyl)amide→MACI-009→ethane-1,2-diol→MACI-011→5-bromo-2-chloropyrimidine→sulfurisocyanatidic chloride→2-methylpropan-2-ol→tert-butyl chlorosulfonylcarbamate→propan-1-amine→tert-butyl N-propylsulfamoylcarbamate→MACI-018
3-(Isopropylamino)propane-1,2-diol→Methyl carbonate→5-(Hydroxymethyl)-3-isopropyloxazolidin-2-one→Benzenesulfonic acid 3-isopropyl-2-oxooxazolidin-5-ylmethyl ester→4-(3-Isopropyl-2-oxooxazolidin-5-ylmethoxy)benzaldehyde→5-[4-(Hydroxymethyl)phenoxymethyl]-3-isopropyloxazolidin-2-one→2-Isopropoxyethanol→4-Hydroxybenzaldehyde→(±)-1-[4-[2-(Isopropoxy)ethoxymethyl]phenoxy]-3-(isopropylamino)propan-2-ol
4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid→methyl 4-formylbenzoate→methyl 5'-methyl-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylate→methyl 4-(6-oxohept-1-yn-4-yl)benzoate→dimethyl carbonate→methyl 4-(8-methoxy-6,8-dioxooct-1-yn-4-yl)benzoate→(E)-4-(7-(hydroxyimino)-6-oxohept-1-yn-4-yl)benzoic acid→pyrimidine-2,4,5,6-tetraamine hydrochloride→di-tert-butyl L-glutamate→di-tert-butyl (4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)-L-glutamate
3-(Isopropylamino)propane-1,2-diol→Methyl carbonate→5-(Hydroxymethyl)-3-isopropyloxazolidin-2-one→Benzenesulfonic acid 3-isopropyl-2-oxooxazolidin-5-ylmethyl ester→4-(3-Isopropyl-2-oxooxazolidin-5-ylmethoxy)benzaldehyde→5-[4-(Hydroxymethyl)phenoxymethyl]-3-isopropyloxazolidin-2-one→2-Isopropoxyethanol→4-Hydroxybenzaldehyde→(±)-1-[4-[2-(Isopropoxy)ethoxymethyl]phenoxy]-3-(isopropylamino)propan-2-ol
8-Methyl-8-azabicyclo[3.2.1]octan-3-one→Carbonicaciddimethyldiester→Hydroxymethane→Methyl8-methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate→1,4-Dibromobenzene→(±)-Methyl(1R*,2S*,3S*,5S*)-3-(4-bromophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate→(±)-Methyl(1R*,2S*,3S*,5S*)-3-(4-bromophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate→1-Bromo-3-fluoropropane→Methyl(1R,2S,3S,5S)-3-(4-bromophenyl)-8-(3-fluoropropyl)-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl(1R,2S,3S,5S)-8-(3-fluoropropyl)-3-[4-(trimethylstannyl)phenyl]-8-azabicyclo[3.2.1]octane-2-carboxylate
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