← Back to patent-cliff list
CAS 67-56-1
Hydroxymethane
Codes: (XXXVI)638294-1-d, Ioflupane (123I)-008, (XXVI)145089-2-c, (X)755707-1-a
Application context (from source-drug indications)
Systolic heart failureFinerenoneDiastolic heart failureFinerenoneHeart failureFinerenoneChronic renal impairmentFinerenoneDiabetic nephropathyFinerenoneType 2 diabetesFinerenoneLewy body dementiaIoflupane (123I)Diagnostic agentIoflupane (123I)ParkinsonismIoflupane (123I)Alzheimer's diseaseIoflupane (123I)Parkinson's diseaseIoflupane (123I)DementiaIoflupane (123I)Alzheimer's diseaseRivastigmine TartrateDementiaRivastigmine TartrateParkinson's diseaseRivastigmine Tartrate抗胆碱能综合征Rivastigmine Tartrate神经行为学表现Rivastigmine TartrateCognitive impairmentRivastigmine TartrateCushing's syndrome68Ga-pentixafor醛固酮增多症68Ga-pentixaforSarcoidosis68Ga-pentixaforGraft-versus-host disease68Ga-pentixaforNeuroendocrine tumour68Ga-pentixaforMarginal zone B-cell lymphoma68Ga-pentixafor
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Finerenone | Tier C — Watch / trade | 2030 |
| Ioflupane (123I) | Tier C — Watch / trade | - |
| Rivastigmine Tartrate | Tier B — Position early | - |
| 68Ga-pentixafor | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
8-Methyl-8-azabicyclo[3.2.1]octan-3-one→Carbonicaciddimethyldiester→Hydroxymethane→Methyl8-methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate→1,4-Dibromobenzene→(±)-Methyl(1R*,2S*,3S*,5S*)-3-(4-bromophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate→(±)-Methyl(1R*,2S*,3S*,5S*)-3-(4-bromophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate→1-Bromo-3-fluoropropane→Methyl(1R,2S,3S,5S)-3-(4-bromophenyl)-8-(3-fluoropropyl)-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl(1R,2S,3S,5S)-8-(3-fluoropropyl)-3-[4-(trimethylstannyl)phenyl]-8-azabicyclo[3.2.1]octane-2-carboxylate
1(S)-(3-Methoxyphenyl)-N,N-dimethylethylamine→(+/-)-3-Methoxy-alpha-methylbenzyl alcohol→(S)-(-)-2-Methyl-2-propanesulfinamide→(SS)-N-[(1S)-1-(3-Methoxyphenyl)ethyl]-2-methylpropane-2-sulfinamide→(1S)-1-(3-Methoxyphenyl)ethanamine→1-Ethyl-3-iodobenzene→Benzamide→N-[(1S)-1-(3-Iodophenyl)ethyl]benzamide→Hydroxymethane→N-[(1S)-1-(3-Methoxyphenyl)ethyl]benzamide→1,1,1-Triphenylmethanamine
2-(9H-Fluoren-9-ylmethoxycarbonylamino)acetic acid→Resin bound [([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)acetyl]oxy→Resin bound glycine→Fmoc-2-Nal-OH→TCP resin bound [[2(S)-amino-3-(naphthalen-2-yl)propanoyl]amino]acetic acid→(2S)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-5-[2-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]pentanoic acid→TCP resin bound [[(2S)-2-([(2S)-2-amino-5-[N'-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]pentanoyl]amino)-3-(naphthalen-2-yl)propanoyl]amino]acetic acid→N5-(4-Nitrobenzene-1-sulfonyl)-N2-[[(prop-2-en-1-yl)oxy]carbonyl]-D-ornithine→TCP resin bound (5S,8S,11R)-5-[(naphthalen-2-yl)methyl]-11-[(4-nitrobenzene-1-sulfonyl)amino]-4,7,10,16-tetraoxo-8-[3-[N'-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]propyl]-17-oxa-3,6,9,15-tetraazaicos-19-en-1-oic acid→Hydroxymethane→(5S,8S,11R)-11-[Methyl(4-nitrobenzene-1-sulfonyl)amino]-5-[(naphthalen-2-yl)methyl]-4,7,10,16-tetraoxo-8-[3-[N'-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]propyl]-17-oxa-3,6,9,15-tetraazaicos-19-en-1-oic acid→TCP resin bound (3R,6S,9S)-3-(3-aminopropyl)-9-[(naphthalen-2-yl)methyl]-2-(4-nitrobenzene-1-sulfonyl)-4,7,10-trioxo-6-[3-[N'-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]propyl]-2,5,8,11-tetraazatridecan-13-oic acid
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 4-Bromo-2-methoxybenzaldehyde Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 4-AMino-5-Methylpyridin-2-ol Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 2-chloro-5-methylpyridin-4-amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.