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CAS 616-38-6
dimethyl carbonateMethyl carbonateCarbonicaciddimethyldiesterCarbonic acid dimethyl diester
登记编号：MACI-003、Bisoprolol-017、PRAL-013、Ioflupane (123I)-007、(IX)992511-1-a
应用背景（按来源药适应症）
肺动脉高压马昔腾坦肺性高血压马昔腾坦慢性病马昔腾坦慢性血栓栓塞性肺高压马昔腾坦血栓栓塞马昔腾坦心绞痛马昔腾坦高血压苯磺酸氨氯地平/富马酸比索洛尔原发性高血压苯磺酸氨氯地平/富马酸比索洛尔外周T细胞淋巴瘤普拉曲沙T-细胞淋巴瘤普拉曲沙实体瘤普拉曲沙血液肿瘤普拉曲沙B-细胞淋巴瘤普拉曲沙皮肤T细胞淋巴瘤普拉曲沙高血压富马酸比索洛尔心绞痛富马酸比索洛尔慢性阻塞性肺疾病富马酸比索洛尔心脏和血管疾病富马酸比索洛尔急性冠脉综合征富马酸比索洛尔禁食富马酸比索洛尔路易氏体型失智症Ioflupane (123I)诊断剂Ioflupane (123I)帕金森综合征Ioflupane (123I)阿尔茨海默病Ioflupane (123I)帕金森病Ioflupane (123I)痴呆Ioflupane (123I)慢性淋巴细胞白血病利沙托克拉急性早幼粒细胞白血病利沙托克拉骨髓增生异常综合征利沙托克拉急性髓细胞样白血病利沙托克拉弥漫性大B-细胞淋巴瘤利沙托克拉系统性红斑狼疮利沙托克拉
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 马昔腾坦Macitentan | Tier B · 提前布局 | - |
| 苯磺酸氨氯地平/富马酸比索洛尔Amlodipine Besylate/Bisoprolol Fumarate | Tier C · 观察 / 贸易 | - |
| 普拉曲沙Pralatrexate | Tier C · 观察 / 贸易 | - |
| 富马酸比索洛尔Bisoprolol Fumarate | Tier C · 观察 / 贸易 | - |
| Ioflupane (123I) | Tier C · 观察 / 贸易 | - |
| 利沙托克拉Lisaftoclax | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
2-(4-bromophenyl)acetic acid→methyl 2-(4-bromophenyl)acetate→dimethyl carbonate→dimethyl 2-(4-bromophenyl)malonate→formimidamide hydrochloride→5-(4-bromophenyl)pyrimidine-4,6-diol→5-(4-bromophenyl)-4,6-dichloropyrimidine→potassium (N-propylsulfamoyl)amide→MACI-009→ethane-1,2-diol→MACI-011→5-bromo-2-chloropyrimidine→sulfurisocyanatidic chloride→2-methylpropan-2-ol→tert-butyl chlorosulfonylcarbamate→propan-1-amine→tert-butyl N-propylsulfamoylcarbamate→MACI-018
3-(Isopropylamino)propane-1,2-diol→Methyl carbonate→5-(Hydroxymethyl)-3-isopropyloxazolidin-2-one→Benzenesulfonic acid 3-isopropyl-2-oxooxazolidin-5-ylmethyl ester→4-(3-Isopropyl-2-oxooxazolidin-5-ylmethoxy)benzaldehyde→5-[4-(Hydroxymethyl)phenoxymethyl]-3-isopropyloxazolidin-2-one→2-Isopropoxyethanol→4-Hydroxybenzaldehyde→(±)-1-[4-[2-(Isopropoxy)ethoxymethyl]phenoxy]-3-(isopropylamino)propan-2-ol
4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid→methyl 4-formylbenzoate→methyl 5'-methyl-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylate→methyl 4-(6-oxohept-1-yn-4-yl)benzoate→dimethyl carbonate→methyl 4-(8-methoxy-6,8-dioxooct-1-yn-4-yl)benzoate→(E)-4-(7-(hydroxyimino)-6-oxohept-1-yn-4-yl)benzoic acid→pyrimidine-2,4,5,6-tetraamine hydrochloride→di-tert-butyl L-glutamate→di-tert-butyl (4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)-L-glutamate
3-(Isopropylamino)propane-1,2-diol→Methyl carbonate→5-(Hydroxymethyl)-3-isopropyloxazolidin-2-one→Benzenesulfonic acid 3-isopropyl-2-oxooxazolidin-5-ylmethyl ester→4-(3-Isopropyl-2-oxooxazolidin-5-ylmethoxy)benzaldehyde→5-[4-(Hydroxymethyl)phenoxymethyl]-3-isopropyloxazolidin-2-one→2-Isopropoxyethanol→4-Hydroxybenzaldehyde→(±)-1-[4-[2-(Isopropoxy)ethoxymethyl]phenoxy]-3-(isopropylamino)propan-2-ol
8-Methyl-8-azabicyclo[3.2.1]octan-3-one→Carbonicaciddimethyldiester→Hydroxymethane→Methyl8-methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate→1,4-Dibromobenzene→(±)-Methyl(1R*,2S*,3S*,5S*)-3-(4-bromophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate→(±)-Methyl(1R*,2S*,3S*,5S*)-3-(4-bromophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate→1-Bromo-3-fluoropropane→Methyl(1R,2S,3S,5S)-3-(4-bromophenyl)-8-(3-fluoropropyl)-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl(1R,2S,3S,5S)-8-(3-fluoropropyl)-3-[4-(trimethylstannyl)phenyl]-8-azabicyclo[3.2.1]octane-2-carboxylate
本站可供应的对应中间体
目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。