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CAS 85-41-6
Phthalimide1,3-Dihydro-1,3-dioxoisoindoleisoindoline-1,3-dione
Codes: Ambroxol- 036, Mosapride Citrate-022, LINSI-011
Application context (from source-drug indications)
Chronic bronchitisRoxithromycin/Ambroxol HydrochlorideBronchitisRoxithromycin/Ambroxol HydrochlorideRespiratory tract infectionRoxithromycin/Ambroxol HydrochloridePneumoniaRoxithromycin/Ambroxol HydrochlorideTracheitisRoxithromycin/Ambroxol HydrochlorideBacterial infectionRoxithromycin/Ambroxol HydrochlorideAnaesthesiaAmbroxol HydrochloridePharyngitisAmbroxol HydrochlorideRespiratory diseaseAmbroxol HydrochlorideBronchitisAmbroxol HydrochlorideParkinson's diseaseAmbroxol HydrochlorideParkinsonismAmbroxol HydrochlorideGastritisMosapride CitrateEnteral feeding intoleranceMosapride CitrateIrritable bowel syndromeMosapride CitrateDyspepsiaMosapride CitrateConstipationMosapride Citrate甲状腺疾病Linsitinib甲状腺相关性眼病Linsitinib慢性淋巴细胞性甲状腺炎Linsitinib突眼症LinsitinibMultiple myelomaLinsitinib唇肿瘤Linsitinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Roxithromycin/Ambroxol Hydrochloride | Tier C — Watch / trade | - |
| Ambroxol Hydrochloride | Tier C — Watch / trade | - |
| Mosapride Citrate | Tier C — Watch / trade | - |
| Linsitinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
[4-(4-Fluorobenzyl)-2-morpholinyl]methylamine→Sulfuric acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine→Phosphoric acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine→1-[4-[(4-Fluorophenyl)methyl]morpholin-2-yl]methanamine hydrogen chloride→2-Methylpropane-1,2,3-tricarboxylic acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine→4-Fluorobenzaldehyde→2-Hydroxyethylamine→2-[(E)-[(4-Fluorophenyl)methylidene]amino]ethan-1-ol→2-[[(4-Fluorophenyl)methyl]amino]ethan-1-ol→2-[(Oxiran-2-yl)methyl]-1H-isoindole-1,3(2H)-dione→1,3-Dihydro-1,3-dioxoisoindole→1,3-Dihydro-1,3-dioxoisoindole potassium salt→(+/-)-Epichlorohydrin
2-(4-Fluorobenzylamino)ethanol→2-Chloro-2-propenonitrile→4-[(4-fluorophenyl)methyl]morpholine-2-carbonitrile→ethyl 4-[(4-fluorophenyl)methyl]morpholine-2-carboxylate→{4-[(4-fluorophenyl)methyl]morpholin-2-yl}methanol→1,3-Dihydro-1,3-dioxoisoindole→2-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)-2,3-dihydro-1H-isoindole-1,3-dione→[(2R)-4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine→4-Amino-5-chloro-2-ethoxybenzoic acid
7-methylquinoline→phenyllithium→7-methyl-2-phenylquinoline→2-phenylquinoline-7-carbaldehyde→2-chloropyrazine→(3-chloropyrazin-2-yl)(2-phenylquinolin-7-yl)methanol→isoindoline-1,3-dione→2-((3-chloropyrazin-2-yl)(2-phenylquinolin-7-yl)methyl)isoindoline-1,3-dione→(3-chloropyrazin-2-yl)(2-phenylquinolin-7-yl)methanamine→3-methylenecyclobutane-1-carboxylic acid→N-((3-chloropyrazin-2-yl)(2-phenylquinolin-7-yl)methyl)-3-methylenecyclobutane-1-carboxamide→7-(8-chloro-3-(3-methylenecyclobutyl)imidazo[1,5-a]pyrazin-1-yl)-2-phenylquinoline→3-(8-chloro-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-(hydroxymethyl)cyclobutan-1-ol→3-(8-chloro-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)cyclobutan-1-one→(1s,3s)-3-(8-chloro-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutan-1-ol
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