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CAS 85-41-6
Phthalimide1,3-Dihydro-1,3-dioxoisoindoleisoindoline-1,3-dione
登记编号：Ambroxol- 036、Mosapride Citrate-022、LINSI-011
应用背景（按来源药适应症）
慢性支气管炎罗红霉素/盐酸氨溴索支气管炎罗红霉素/盐酸氨溴索呼吸道感染罗红霉素/盐酸氨溴索肺炎罗红霉素/盐酸氨溴索气管炎罗红霉素/盐酸氨溴索细菌感染罗红霉素/盐酸氨溴索麻醉盐酸氨溴索咽炎盐酸氨溴索呼吸道疾病盐酸氨溴索支气管炎盐酸氨溴索帕金森病盐酸氨溴索帕金森综合征盐酸氨溴索胃炎枸橼酸莫沙必利肠内喂养不耐受枸橼酸莫沙必利肠易激综合征枸橼酸莫沙必利消化不良枸橼酸莫沙必利便秘枸橼酸莫沙必利甲状腺疾病Linsitinib甲状腺相关性眼病Linsitinib慢性淋巴细胞性甲状腺炎Linsitinib突眼症Linsitinib多发性骨髓瘤Linsitinib唇肿瘤Linsitinib
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 罗红霉素/盐酸氨溴索Roxithromycin/Ambroxol Hydrochloride | Tier C · 观察 / 贸易 | - |
| 盐酸氨溴索Ambroxol Hydrochloride | Tier C · 观察 / 贸易 | - |
| 枸橼酸莫沙必利Mosapride Citrate | Tier C · 观察 / 贸易 | - |
| Linsitinib | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
[4-(4-Fluorobenzyl)-2-morpholinyl]methylamine→Sulfuric acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine→Phosphoric acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine→1-[4-[(4-Fluorophenyl)methyl]morpholin-2-yl]methanamine hydrogen chloride→2-Methylpropane-1,2,3-tricarboxylic acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine→4-Fluorobenzaldehyde→2-Hydroxyethylamine→2-[(E)-[(4-Fluorophenyl)methylidene]amino]ethan-1-ol→2-[[(4-Fluorophenyl)methyl]amino]ethan-1-ol→2-[(Oxiran-2-yl)methyl]-1H-isoindole-1,3(2H)-dione→1,3-Dihydro-1,3-dioxoisoindole→1,3-Dihydro-1,3-dioxoisoindole potassium salt→(+/-)-Epichlorohydrin
2-(4-Fluorobenzylamino)ethanol→2-Chloro-2-propenonitrile→4-[(4-fluorophenyl)methyl]morpholine-2-carbonitrile→ethyl 4-[(4-fluorophenyl)methyl]morpholine-2-carboxylate→{4-[(4-fluorophenyl)methyl]morpholin-2-yl}methanol→1,3-Dihydro-1,3-dioxoisoindole→2-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)-2,3-dihydro-1H-isoindole-1,3-dione→[(2R)-4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine→4-Amino-5-chloro-2-ethoxybenzoic acid
7-methylquinoline→phenyllithium→7-methyl-2-phenylquinoline→2-phenylquinoline-7-carbaldehyde→2-chloropyrazine→(3-chloropyrazin-2-yl)(2-phenylquinolin-7-yl)methanol→isoindoline-1,3-dione→2-((3-chloropyrazin-2-yl)(2-phenylquinolin-7-yl)methyl)isoindoline-1,3-dione→(3-chloropyrazin-2-yl)(2-phenylquinolin-7-yl)methanamine→3-methylenecyclobutane-1-carboxylic acid→N-((3-chloropyrazin-2-yl)(2-phenylquinolin-7-yl)methyl)-3-methylenecyclobutane-1-carboxamide→7-(8-chloro-3-(3-methylenecyclobutyl)imidazo[1,5-a]pyrazin-1-yl)-2-phenylquinoline→3-(8-chloro-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-(hydroxymethyl)cyclobutan-1-ol→3-(8-chloro-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)cyclobutan-1-one→(1s,3s)-3-(8-chloro-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutan-1-ol
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