CAS 85-44-9

isobenzofuran-1,3-dione2-Benzofuran-1,3-dionePhthalic anhydride

Codes: LINA-015, TREL-014, ALOG-024, Ambroxol- 034, AMRU-006, Cefonicid-002, BUPHTH-001, PHB-001

Application context (from source-drug indications)

Type 2 diabetesLinagliptinType 2 diabetesTrelagliptin SuccinateDiabetesTrelagliptin SuccinateType 2 diabetesAlogliptin BenzoateDiabetesAlogliptin BenzoateAcute coronary syndromeAlogliptin BenzoateChronic bronchitisRoxithromycin/Ambroxol HydrochlorideBronchitisRoxithromycin/Ambroxol HydrochlorideRespiratory tract infectionRoxithromycin/Ambroxol HydrochloridePneumoniaRoxithromycin/Ambroxol HydrochlorideTracheitisRoxithromycin/Ambroxol HydrochlorideBacterial infectionRoxithromycin/Ambroxol HydrochlorideAnaesthesiaAmbroxol HydrochloridePharyngitisAmbroxol HydrochlorideRespiratory diseaseAmbroxol HydrochlorideBronchitisAmbroxol HydrochlorideParkinson's diseaseAmbroxol HydrochlorideParkinsonismAmbroxol HydrochlorideNon-small cell lung cancerAmrubicin HydrochlorideSmall cell lung cancerAmrubicin HydrochlorideLung cancerAmrubicin HydrochlorideSarcomaAmrubicin HydrochlorideMetastatic breast cancerAmrubicin HydrochlorideSolid tumourAmrubicin HydrochlorideBacterial infectionCefonicid SodiumGlioblastomaButylidenephthalideGliomaButylidenephthalideAmyotrophic lateral sclerosisButylidenephthalideIschaemic strokePotassium-Hydroxypentyl Benzoate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Linagliptin	Tier C — Watch / trade	2029
Trelagliptin Succinate	Tier C — Watch / trade	-
Alogliptin Benzoate	Tier C — Watch / trade	-
Roxithromycin/Ambroxol Hydrochloride	Tier C — Watch / trade	-
Ambroxol Hydrochloride	Tier C — Watch / trade	-
Amrubicin Hydrochloride	Tier C — Watch / trade	-
Cefonicid Sodium	Tier C — Watch / trade	-
Butylidenephthalide	Tier C — Watch / trade	-
Potassium-Hydroxypentyl Benzoate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

LinagliptinOptimised routesteps: 7total yield: /

8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione→2-(chloromethyl)-4-methylquinazoline→8-bromo-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione→1-(2-aminophenyl)ethan-1-one→2-chloroacetonitrile→(R)-2-(piperidin-3-yl)isoindoline-1,3-dione (2S,3S)-2,3-dihydroxysuccinate→(R)-7-(but-2-yn-1-yl)-8-(3-(1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione→pyridin-3-amine→piperidin-3-amine→isobenzofuran-1,3-dione→2-(piperidin-3-yl)isoindoline-1,3-dione→(2S,3S)-2,3-dihydroxysuccinic acid

Trelagliptin SuccinateOptimised routesteps: 4total yield: /

2-(bromomethyl)-4-fluorobenzonitrile→6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione→2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile→(R)-piperidin-3-amine→(R)-2-(piperidin-3-yl)isoindoline-1,3-dione→(R)-2-((6-(3-(1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile→isobenzofuran-1,3-dione

Alogliptin BenzoateOptimised routesteps: 5total yield: /

6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione→(R)-tert-butyl (1-(3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)piperidin-3-yl)carbamate→2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile→(R)-2-(piperidin-3-yl)isoindoline-1,3-dione→(R)-2-((6-(3-(1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile→(R)-piperidin-3-amine dihydrochloride→isobenzofuran-1,3-dione

Roxithromycin/Ambroxol HydrochlorideOptimised routesteps: 3total yield: 10.9g(Ambroxol- 037)

2-Benzofuran-1,3-dione→Isourea→Phthalimide→3,5-Dibromo-2-aminobenzoic acid→2-Aminobenzoic acid

Ambroxol HydrochlorideOptimised routesteps: 3total yield: 10.9g(Ambroxol- 037)

2-Benzofuran-1,3-dione→Isourea→Phthalimide→3,5-Dibromo-2-aminobenzoic acid→2-Aminobenzoic acid

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Taizhou GMP-like Site	3-Methylxanthine Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	8-Bromo-3-methyl-3,9-dihydro-1H-purine-2,6-dione Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	8-Bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	2-(Chloromethyl)-4-methylquinazoline Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	8-Bromo-7-(but-2-yn-1-yl)-3-methy1-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	[(3R)-1-[7-(2-Butynyl)-2,3,6,7-tetrahydro-3-methy1-1-[(4-methy1-2-quinazolinyl)methyl]-2,6-dioxo-1H-purin-8-yll-3-piperidinyllcarbamicacid 1,1-dimethylethyl ester Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.