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CAS 867-13-0
ethyl 2-(diethoxyphosphoryl)acetate(Diethoxyphosphinyl)acetic acid ethyl esterTriethyl phosphonoacetateTEPA
Codes: PALB-020, CARI-011, (XXV)992511-1-d, ALK-001-002
Physicochemical properties & identification
- Appearance
- Colourless to pale-yellow clear liquid
- Solubility
- Insoluble in water; miscible with most organic solvents
- Storage
- Sealed under nitrogen, cool and protected from moisture (the ester hydrolyses readily)
Applications
- · Horner–Wadsworth–Emmons (HWE) olefinating reagent: the classic construction of (E)-α,β-unsaturated esters
- · Drug-synthesis applications including installation of the side-chain double bond on the cariprazine route
Application context (from source-drug indications)
Breast cancerPalbociclibMajor depressive disorderCariprazine HydrochlorideSchizophreniaCariprazine HydrochlorideManiaCariprazine HydrochlorideChronic lymphocytic leukaemiaLisaftoclaxAcute promyelocytic leukaemiaLisaftoclaxMyelodysplastic syndromeLisaftoclaxAcute myeloid leukaemiaLisaftoclaxDiffuse large B-cell lymphomaLisaftoclaxSystemic lupus erythematosusLisaftoclaxStargardt病Gildeuretinol地图状萎缩Gildeuretinol年龄相关性黄斑变性Gildeuretinol
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Palbociclib | Tier A — Act now | 2027 |
| Cariprazine Hydrochloride | Tier A — Act now | 2029 |
| Lisaftoclax | Tier C — Watch / trade | - |
| Gildeuretinol | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
cyclopentanamine→tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate→tert-butyl 4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate→ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate→ethyl 4-(cyclopentylamino)-2-(methylthio)pyrimidine-5-carboxylate→(4-(cyclopentylamino)-2-(methylthio)pyrimidin-5-yl)methanol→4-(cyclopentylamino)-2-(methylthio)pyrimidine-5-carbaldehyde→1-(4-(cyclopentylamino)-2-(methylthio)pyrimidin-5-yl)ethanol→1-(4-(cyclopentylamino)-2-(methylthio)pyrimidin-5-yl)ethan-1-one→ethyl 2-(diethoxyphosphoryl)acetate→8-cyclopentyl-5-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one→6-bromo-8-cyclopentyl-5-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one→2-((4-nitrophenyl)sulfonyl)-3-phenyl-1,2-oxaziridine→6-bromo-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one→tributyl(1-ethoxyvinyl)stannane→tert-butyl 4-(6-((8-cyclopentyl-6-(1-ethoxyvinyl)-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
dimethylcarbamic chloride→4-aminocyclohexanone→1,1-dimethyl-3-(4-oxocyclohexyl)urea→ethyl 2-(diethoxyphosphoryl)acetate→ethyl 2-(4-(3,3-dimethylureido)cyclohexylidene)acetate→ethyl 2-((1r,4r)-4-(3,3-dimethylureido)cyclohexyl)acetate→3-((1r,4r)-4-(2-hydroxyethyl)cyclohexyl)-1,1-dimethylurea→1,1-dimethyl-3-((1r,4r)-4-(2-oxoethyl)cyclohexyl)urea→1-(2,3-dichlorophenyl)piperazine
Cyclobutanone→Spiro[3.5]nonane-6,8-dione→Spiro[3.5]nonan-6-one→(4-Chlorophenyl)boranediol→1-(1,1-Dimethylethoxycarbonyl)piperazine→6-Chlorospiro[3.5]non-6-ene-7-carbaldehyde→(Diethoxyphosphinyl)acetic acid ethyl ester→Ethyl cyclobutylideneacetate→1,3-Acetonedicarboxylic acid diethyl ester→Formyldimethylamine→6-(4-Chlorophenyl)spiro[3.5]non-6-ene-7-carbaldehyde→N-Boc-1-[[8-(4-chlorophenyl)spiro[3.5]non-7-en-7-yl]methyl]piperazine→1-[[6-(4-Chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl]piperazine dihydrogen chloride→1-[[6-(4-Chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl]piperazine
(E)-4-(2,6,6-trimethylcyclohex-1-enyl)but-3-en-2-one→ethyl 2-(diethoxyphosphoryl)acetate→(2E,4E)-ethyl 3-methyl-5-(2,6,6-trimethylcyclohex-1-enyl)penta-2,4-dienoate→(2Z,4E)-3-methyl-5-(2,6,6-trimethylcyclohex-1-en-1-yl)penta-2,4-dien-1-ol→(2E,4E)-3-methyl-5-(2,6,6-trimethylcyclohex-1-en-1-yl)penta-2,4-dienal→1,1,1-3D-Acetone→(3E,5E,7E)- 20,20.20-trideutero-6-methyl-8-(2,6,6-trimethylcyclohex-1-enyl)octa-3,5,7-trien-2-one→(2E,4E,6E,8E)-ethyl 20,20.20-trideutero-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoate→(2E,4E,6E,8E)-20,20.20-trideutero-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraen-1-ol
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | Tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | PD 0332991 HCl Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.