← Back to patent-cliff list
CAS 1191-95-3
cyclobutanoneCyclobutanone
Codes: APAL-014, (I)992511-1-a,(I)992511-1-d
Application context (from source-drug indications)
Castration-resistant prostate cancerApalutamideProstate cancerApalutamideChronic lymphocytic leukaemiaLisaftoclaxAcute promyelocytic leukaemiaLisaftoclaxMyelodysplastic syndromeLisaftoclaxAcute myeloid leukaemiaLisaftoclaxDiffuse large B-cell lymphomaLisaftoclaxSystemic lupus erythematosusLisaftoclax
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Apalutamide | Tier A — Act now | 2030 |
| Lisaftoclax | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-(trifluoromethyl)pyridin-2-ol→5-iodo-3-(trifluoromethyl)pyridin-2-ol→2-chloro-5-iodo-3-(trifluoromethyl)pyridine→(4-methoxyphenyl)methanamine→6-chloro-N-(4-methoxybenzyl)-5-(trifluoromethyl)pyridin-3-amine→5-((4-methoxybenzyl)amino)-3-(trifluoromethyl)picolinonitrile→5-amino-3-(trifluoromethyl)picolinonitrile→5-isothiocyanato-3-(trifluoromethyl)picolinonitrile→4-((1-cyanocyclobutyl)amino)-2-fluoro-N-methylbenzamide→2,4-difluorobenzoyl chloride→2,4-difluoro-N-methylbenzamide→2-fluoro-4-((4-methoxybenzyl)amino)-N-methylbenzamide→4-amino-2-fluoro-N-methylbenzamide→cyclobutanone
Cyclobutanone→1-(Triphenylphosphoranylidene)-2-propanone→1-Cyclobutylidenepropan-2-one→Carbonic acid dimethyl diester→Spiro[3.5]nonane-6,8-dione→8-(2-Methylpropoxy)spiro[3.5]non-7-en-6-one→Spiro[3.5]non-7-en-6-one→Spiro[3.5]nonan-6-one→1,3-Dimethyl propanedioate→Methyl 6-oxospiro[3.5]nonane-7-carboxylate→Methyl 6-(((trifluoromethyl)sulfonyl)oxy) spiro[3.5]non-6-ene-7-carboxylate→(4-Chlorophenyl)boranediol→Methyl 6-(4-chlorophenyl)spiro[3.5]non-6-ene-7-carboxylate→[6-(4-Chlorophenyl)spiro[3.5]non-6-en-7-yl]methanol→7-(Chloromethyl)-6-(4-chlorophenyl)spiro[3.5]non-6-ene
Cyclobutanone→Spiro[3.5]nonane-6,8-dione→Spiro[3.5]nonan-6-one→(4-Chlorophenyl)boranediol→1-(1,1-Dimethylethoxycarbonyl)piperazine→6-Chlorospiro[3.5]non-6-ene-7-carbaldehyde→(Diethoxyphosphinyl)acetic acid ethyl ester→Ethyl cyclobutylideneacetate→1,3-Acetonedicarboxylic acid diethyl ester→Formyldimethylamine→6-(4-Chlorophenyl)spiro[3.5]non-6-ene-7-carbaldehyde→N-Boc-1-[[8-(4-chlorophenyl)spiro[3.5]non-7-en-7-yl]methyl]piperazine→1-[[6-(4-Chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl]piperazine dihydrogen chloride→1-[[6-(4-Chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl]piperazine
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 5-Amino-3-(trifluoromethyl)picolinonitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | N-Boc-1-aminocyclobutanecarboxylic acid Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 1-amino-N-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]Cyclobutanecarboxamide Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.