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CAS 867-13-0
ethyl 2-(diethoxyphosphoryl)acetate(Diethoxyphosphinyl)acetic acid ethyl ester磷酸二乙酯基乙酸乙酯三乙氧基磷酰乙酸乙酯Triethyl phosphonoacetateTEPA
登记编号：PALB-020、CARI-011、(XXV)992511-1-d、ALK-001-002
理化性质与标识
- 分子式
- C8H17O4P
- 分子量
- 208.20
- 外观
- 无色至淡黄色透明液体
- 溶解性
- 不溶于水，与大多数有机溶剂混溶
- 贮存
- 氮气保护密封，阴凉避潮（酯基易水解）
应用
- · Horner–Wadsworth–Emmons（HWE）烯化试剂：E-式 α,β-不饱和酯的经典构建
- · 卡利拉嗪路线引入侧链双键等药物合成应用
应用背景（按来源药适应症）
乳腺癌哌柏西利重度抑郁症卡利拉嗪盐酸盐精神分裂症卡利拉嗪盐酸盐躁狂症卡利拉嗪盐酸盐慢性淋巴细胞白血病利沙托克拉急性早幼粒细胞白血病利沙托克拉骨髓增生异常综合征利沙托克拉急性髓细胞样白血病利沙托克拉弥漫性大B-细胞淋巴瘤利沙托克拉系统性红斑狼疮利沙托克拉Stargardt病Gildeuretinol地图状萎缩Gildeuretinol年龄相关性黄斑变性Gildeuretinol
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 哌柏西利Palbociclib | Tier A · 立即攻坚 | 2027 |
| 卡利拉嗪盐酸盐Cariprazine Hydrochloride | Tier A · 立即攻坚 | 2029 |
| 利沙托克拉Lisaftoclax | Tier C · 观察 / 贸易 | - |
| Gildeuretinol | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
cyclopentanamine→tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate→tert-butyl 4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate→ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate→ethyl 4-(cyclopentylamino)-2-(methylthio)pyrimidine-5-carboxylate→(4-(cyclopentylamino)-2-(methylthio)pyrimidin-5-yl)methanol→4-(cyclopentylamino)-2-(methylthio)pyrimidine-5-carbaldehyde→1-(4-(cyclopentylamino)-2-(methylthio)pyrimidin-5-yl)ethanol→1-(4-(cyclopentylamino)-2-(methylthio)pyrimidin-5-yl)ethan-1-one→ethyl 2-(diethoxyphosphoryl)acetate→8-cyclopentyl-5-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one→6-bromo-8-cyclopentyl-5-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one→2-((4-nitrophenyl)sulfonyl)-3-phenyl-1,2-oxaziridine→6-bromo-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one→tributyl(1-ethoxyvinyl)stannane→tert-butyl 4-(6-((8-cyclopentyl-6-(1-ethoxyvinyl)-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
dimethylcarbamic chloride→4-aminocyclohexanone→1,1-dimethyl-3-(4-oxocyclohexyl)urea→ethyl 2-(diethoxyphosphoryl)acetate→ethyl 2-(4-(3,3-dimethylureido)cyclohexylidene)acetate→ethyl 2-((1r,4r)-4-(3,3-dimethylureido)cyclohexyl)acetate→3-((1r,4r)-4-(2-hydroxyethyl)cyclohexyl)-1,1-dimethylurea→1,1-dimethyl-3-((1r,4r)-4-(2-oxoethyl)cyclohexyl)urea→1-(2,3-dichlorophenyl)piperazine
Cyclobutanone→Spiro[3.5]nonane-6,8-dione→Spiro[3.5]nonan-6-one→(4-Chlorophenyl)boranediol→1-(1,1-Dimethylethoxycarbonyl)piperazine→6-Chlorospiro[3.5]non-6-ene-7-carbaldehyde→(Diethoxyphosphinyl)acetic acid ethyl ester→Ethyl cyclobutylideneacetate→1,3-Acetonedicarboxylic acid diethyl ester→Formyldimethylamine→6-(4-Chlorophenyl)spiro[3.5]non-6-ene-7-carbaldehyde→N-Boc-1-[[8-(4-chlorophenyl)spiro[3.5]non-7-en-7-yl]methyl]piperazine→1-[[6-(4-Chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl]piperazine dihydrogen chloride→1-[[6-(4-Chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl]piperazine
(E)-4-(2,6,6-trimethylcyclohex-1-enyl)but-3-en-2-one→ethyl 2-(diethoxyphosphoryl)acetate→(2E,4E)-ethyl 3-methyl-5-(2,6,6-trimethylcyclohex-1-enyl)penta-2,4-dienoate→(2Z,4E)-3-methyl-5-(2,6,6-trimethylcyclohex-1-en-1-yl)penta-2,4-dien-1-ol→(2E,4E)-3-methyl-5-(2,6,6-trimethylcyclohex-1-en-1-yl)penta-2,4-dienal→1,1,1-3D-Acetone→(3E,5E,7E)- 20,20.20-trideutero-6-methyl-8-(2,6,6-trimethylcyclohex-1-enyl)octa-3,5,7-trien-2-one→(2E,4E,6E,8E)-ethyl 20,20.20-trideutero-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoate→(2E,4E,6E,8E)-20,20.20-trideutero-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraen-1-ol
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | Tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | PD 0332991 HCl Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。