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氨氯地平乳清酸盐

Tier C · 观察 / 贸易

Amlodipine Orotate

Dong-A ST Co Ltd
原研
2005
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型

靶点：VDCCs

适应症（已批准）：变异型心绞痛、高血压、缺血性心脏病、稳定型心绞痛

各地区研发/上市状态

美国
-
欧盟
-
中国
-
日本
-

合成路线与中间体11 routes

原研路线 × 0优化路线（非专利）× 11工艺路线 × 0

路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。

优化Route 1步骤 3 · 总收率 /
(I)109067-1-a638-07-3(II)109067-1-a1517-05-1(III)109067-1-a88150-45-2(IV)109067-1-a14205-39-1(V)109067-1-a89-98-5(VI)109067-1-a88150-46-3API · 氨氯地平乳清酸盐
编号CAS 号中间体名称
(I)109067-1-a638-07-3Ethyl 4-chloro-3-oxobutanoate
(II)109067-1-a1517-05-12-azidoethan-1-ol
(III)109067-1-a88150-45-2ethyl 4-(2-azidoethoxy)-3-oxobutanoate
(IV)109067-1-a14205-39-13-Amino-2-butenoic acid methyl ester
(V)109067-1-a89-98-52-Chlorobenzaldehyde
(VI)109067-1-a88150-46-33-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
优化Route 2步骤 4 · 总收率 /
(I)109067-2-a638-07-3(II)109067-2-a2222844-70-2(III)109067-2-a3891-07-4(IV)109067-2-a88150-75-8(V)109067-2-a—(VI)109067-2-a1170036-31-3(VII)109067-2-a103094-30-0,88150-62-3API · 氨氯地平乳清酸盐
编号CAS 号中间体名称
(I)109067-2-a638-07-3Ethyl 4-chloro-3-oxobutanoate
(II)109067-2-a2222844-70-2Ethyl 4-[(4-methylbenzene-1-sulfonyl)oxy]-3-oxobutanoate
(III)109067-2-a3891-07-4N-(2-Hydroxyethyl)phthalimide
(IV)109067-2-a88150-75-8Ethyl 4-(2-phthalimidoethoxy)acetoacetate
(V)109067-2-a-Ethyl (2Z)-3-amino-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]but-2-enoate
(VI)109067-2-a1170036-31-3Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate
(VII)109067-2-a103094-30-0,88150-62-33-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
优化Route 3步骤 3 · 总收率 /
(I)109067-3-a638-07-3(II)109067-3-a1517-05-1(III)109067-3-a88150-45-2(IV)109067-3-a1170036-31-3(V)109067-3-a88150-46-3API · 氨氯地平乳清酸盐
编号CAS 号中间体名称
(I)109067-3-a638-07-34-Chloro-3-oxobutyric acid ethyl ester
(II)109067-3-a1517-05-12-azidoethan-1-ol
(III)109067-3-a88150-45-2ethyl 4-(2-azidoethoxy)-3-oxobutanoate
(IV)109067-3-a1170036-31-3Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate
(V)109067-3-a88150-46-33-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
优化Route 4步骤 6 · 总收率 /
(I)109067-4-a6065-82-3(II)109067-4-a621-63-6(III)109067-4-a638-07-3(IV)109067-4-a225939-10-6(V)109067-4-a89-98-5(VI)109067-4-a—(VII)109067-4-a14205-39-1(VIII)109067-4-a194472-23-6(IX)109067-4-a—(X)109067-4-a—(XI)109067-4-a1170036-31-3API · 氨氯地平乳清酸盐
编号CAS 号中间体名称
(I)109067-4-a6065-82-3Diethoxyacetic acid ethyl ester
(II)109067-4-a621-63-62,2-Diethoxyethanol
(III)109067-4-a638-07-34-Chloro-3-oxobutyric acid ethyl ester
(IV)109067-4-a225939-10-6ethyl 4-(2,2-diethoxyethoxy)-3-oxobutanoate
(V)109067-4-a89-98-52-Chlorobenzaldehyde
(VI)109067-4-a-ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-4-(2,2-dimethoxyethoxy)-3-oxobutanoate
(VII)109067-4-a14205-39-1Methyl 3-amino-2-butenoate
(VIII)109067-4-a194472-23-63-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,2-dimethoxyethoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(IX)109067-4-a-3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(X)109067-4-a-ethyl (2E)-3-amino-4-(2,2-diethoxyethoxy)but-2-enoate
(XI)109067-4-a1170036-31-3Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate
优化Route 5步骤 4 · 总收率 /
(I)109067-5-a141-43-5(II)109067-5-a33885-01-7(III)109067-5-a24070-16-4(IV)109067-5-a638-07-3(V)109067-5-a156366-26-6(VI)109067-5-a89-98-5(VII)109067-5-a14205-39-1(VIII)109067-5-a156366-27-7API · 氨氯地平乳清酸盐
编号CAS 号中间体名称
(I)109067-5-a141-43-5在售2-Aminoethanol
(II)109067-5-a33885-01-7(2-chloro-1,1-diphenylethyl)benzene
(III)109067-5-a24070-16-42-[(triphenylmethyl)amino]ethan-1-ol
(IV)109067-5-a638-07-3Ethyl 4-chloroacetoacetate
(V)109067-5-a156366-26-6ethyl 3-oxo-4-{2-[(triphenylmethyl)amino]ethoxy}butanoate
(VI)109067-5-a89-98-52-Chlorobenzaldehyde
(VII)109067-5-a14205-39-13-Amino-2-butenoic acid methyl ester
(VIII)109067-5-a156366-27-73-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-({2-[(triphenylmethyl)amino]ethoxy}methyl)-1,4-dihydropyridine-3,5-dicarboxylate
优化Route 6步骤 8 · 总收率 /
(I)109067-6-a1517-05-1(II)109067-6-a79-11-8(III)109067-6-a79598-48-4(IV)109067-6-a2033-24-1(V)109067-6-a109-78-4(VI)109067-6-a103069-47-2(VII)109067-6-a89-98-5(VIII)109067-6-a14205-39-1(IX)109067-6-a134471-46-8(X)109067-6-a134471-71-9(XI)109067-6-a66051-01-2(XII)109067-6-a—(XIII)109067-6-a103094-34-4(XIV)109067-6-a125711-60-6(XV)109067-6-a103129-82-4API · 氨氯地平乳清酸盐
编号CAS 号中间体名称
(I)109067-6-a1517-05-12-azidoethan-1-ol
(II)109067-6-a79-11-82-Chloroacetic acid
(III)109067-6-a79598-48-42-(2-azidoethoxy)acetic acid
(IV)109067-6-a2033-24-12,2-Dimethyl-1,3-dioxane-4,6-dione
(V)109067-6-a109-78-4在售3-Hydroxypropionitrile
(VI)109067-6-a103069-47-22-cyanoethyl 4-(2-azidoethoxy)-3-oxobutanoate
(VII)109067-6-a89-98-52-Chlorobenzaldehyde
(VIII)109067-6-a14205-39-13-Amino-2-butenoic acid methyl ester
(IX)109067-6-a134471-46-83-(2-cyanoethyl) 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(X)109067-6-a134471-71-92-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine-3-carboxylic acid
(XI)109067-6-a66051-01-2(2S)-2-methoxy-2-phenylethan-1-ol
(XII)109067-6-a-3-(2S)-2-methoxy-2-phenylethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(XIII)109067-6-a103094-34-43-[(2S)-2-Methoxy-2-phenylethyl] 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(XIV)109067-6-a125711-60-63-Ethyl 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(XV)109067-6-a103129-82-43-Ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
优化Route 7步骤 6 · 总收率 /
(I)109067-8-a—(II)109067-8-a,(II)109067-8-b638-07-3(III)109067-8-a194472-29-2(IV)109067-8-a,(IV)109067-8-b89-98-5(V)109067-8-a,(V)109067-8-b14205-39-1(VI)109067-8-a194472-10-1(VII)109067-8-a194472-12-3(VIII)109067-8-a,(VIII)109067-8-b194472-14-5(IX)109067-8-a,(IX)109067-8-b—API · 氨氯地平乳清酸盐
编号CAS 号中间体名称
(I)109067-8-a-[5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methanol
(II)109067-8-a,(II)109067-8-b638-07-34-Chloro-3-oxobutyric acid ethyl ester
(III)109067-8-a194472-29-2ethyl 4-({5-[(4-ethoxy-2,4-dioxobutoxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methoxy)-3-oxobutanoate
(IV)109067-8-a,(IV)109067-8-b89-98-52-Chlorobenzaldehyde
(V)109067-8-a,(V)109067-8-b14205-39-13-Amino-2-butenoic acid methyl ester
(VI)109067-8-a194472-10-13-ethyl 5-methyl 4-(2-chlorophenyl)-2-({[5-({[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(VII)109067-8-a194472-12-33-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(4-{[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}-2,3-dihydroxybutoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(VIII)109067-8-a,(VIII)109067-8-b194472-14-53-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[(2-oxoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate
(IX)109067-8-a,(IX)109067-8-b-3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
优化Route 8步骤 4 · 总收率 /
(II)109067-8-a,(II)109067-8-b638-07-3(IV)109067-8-a,(IV)109067-8-b89-98-5(V)109067-8-a,(V)109067-8-b14205-39-1(VIII)109067-8-a,(VIII)109067-8-b194472-14-5(IX)109067-8-a,(IX)109067-8-b—(X)109067-8-b22323-82-6(XI)109067-8-b110464-45-4(XII)109067-8-b—(XIII)109067-8-b194472-30-5API · 氨氯地平乳清酸盐
编号CAS 号中间体名称
(II)109067-8-a,(II)109067-8-b638-07-34-Chloro-3-oxobutyric acid ethyl ester
(IV)109067-8-a,(IV)109067-8-b89-98-52-Chlorobenzaldehyde
(V)109067-8-a,(V)109067-8-b14205-39-13-Amino-2-butenoic acid methyl ester
(VIII)109067-8-a,(VIII)109067-8-b194472-14-53-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[(2-oxoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate
(IX)109067-8-a,(IX)109067-8-b-3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(X)109067-8-b22323-82-6[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methanol
(XI)109067-8-b110464-45-4ethyl 4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]-3-oxobutanoate
(XII)109067-8-b-3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(XIII)109067-8-b194472-30-53-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,3-dihydroxypropoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
优化Route 9步骤 5 · 总收率 /
(I)109067-9-a23326-27-4(II)109067-9-a100-46-9(III)109067-9-a24405-35-4(IV)109067-9-a—(V)109067-9-a39562-06-6(VI)109067-9-a1309115-67-0(VII)109067-9-a1517-05-1(VIII)109067-9-a—API · 氨氯地平乳清酸盐
编号CAS 号中间体名称
(I)109067-9-a23326-27-42-Butynoic acid methyl ester
(II)109067-9-a100-46-9在售1-Phenylmethylamine
(III)109067-9-a24405-35-4ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate
(IV)109067-9-a-3-methyl 5-propyl 1-benzyl-4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
(V)109067-9-a39562-06-63-ethyl 5-methyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
(VI)109067-9-a1309115-67-03-ethyl 5-methyl 2-(bromomethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(VII)109067-9-a1517-05-12-azidoethan-1-ol
(VIII)109067-9-a-3-methyl 5-propyl 6-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylate
优化Route 10步骤 2 · 总收率 /
(I)158395-3-a2032-35-1(II)158395-3-a—(III)158395-3-a621-63-6API · 氨氯地平乳清酸盐
编号CAS 号中间体名称
(I)158395-3-a2032-35-12-Bromo-1,1-diethoxyethane
(II)158395-3-a-2,2-Diethoxyethyl acetate
(III)158395-3-a621-63-62,2-Diethoxyethanol
优化Route 11步骤 1 · 总收率 /
(I)180072-57-a674-82-8(II)180072-57-a—API · 氨氯地平乳清酸盐
编号CAS 号中间体名称
(I)180072-57-a674-82-8在售4-Methyleneoxetan-2-one
(II)180072-57-a-4-Chloro-3-oxobutanoic acid

常见问题（FAQ）

氨氯地平乳清酸盐的适应症有哪些？

已批准的适应症包括：变异型心绞痛、高血压、缺血性心脏病、稳定型心绞痛。

氨氯地平乳清酸盐的专利什么时候到期？

氨氯地平乳清酸盐的专利到期年暂无公开口径，本页会在数据管道核实后更新。

氨氯地平乳清酸盐有几条合成路线？

本站收录 11 条合成路线，最短路线 1 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。

氨氯地平乳清酸盐的关键中间体在哪里可以采购？

氨氯地平乳清酸盐的多条路线中间体已挂接 CAS 档案，其中 4 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。

如何获取氨氯地平乳清酸盐中间体的报价？

在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。

数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22