← 返回专利悬崖列表
CAS 141-43-5
2-aminoethan-1-ol2-Aminoethanol2-Aminoethyl alcohol1-Amino-2-hydroxyethane2-Hydroxyethylamine
登记编号：RIVA-001、FINA-017、(I)109067-5-a、(Ia)109067-10-a、Miltefosine-008、Mosapride Citrate-018、CBL-0137-001
应用背景（按来源药适应症）
肺栓塞利伐沙班中风利伐沙班先天性心脏缺损利伐沙班血栓形成利伐沙班静脉血栓栓塞利伐沙班冠状动脉疾病利伐沙班外耳炎非那沙星分泌性中耳炎非那沙星中耳炎非那沙星泌尿系统感染非那沙星肾盂肾炎非那沙星革兰氏阴性细菌感染非那沙星高血压Olmesartan Medoxomil/Amlodipine orotate原发性高血压缬沙坦/氨氯地平乳清酸盐变异型心绞痛氨氯地平乳清酸盐高血压氨氯地平乳清酸盐缺血性心脏病氨氯地平乳清酸盐稳定型心绞痛氨氯地平乳清酸盐高血压樟脑磺酸氨氯地平高血压马来酸氨氯地平心绞痛马来酸氨氯地平慢性肾功能不全马来酸氨氯地平肾性高血压马来酸氨氯地平心脏病马来酸氨氯地平血管疾病马来酸氨氯地平利什曼原虫感染米替福新皮肤利什曼病米替福新慢性荨麻疹米替福新内脏利什曼病米替福新粘膜皮肤利什曼病米替福新胃炎枸橼酸莫沙必利肠内喂养不耐受枸橼酸莫沙必利肠易激综合征枸橼酸莫沙必利消化不良枸橼酸莫沙必利便秘枸橼酸莫沙必利
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 利伐沙班Rivaroxaban | Tier A · 立即攻坚 | 2026 |
| 非那沙星Finafloxacin | Tier C · 观察 / 贸易 | - |
| Olmesartan Medoxomil/Amlodipine orotate | Tier C · 观察 / 贸易 | - |
| 缬沙坦/氨氯地平乳清酸盐Valsartan/Amlodipine Orotate | Tier C · 观察 / 贸易 | - |
| 氨氯地平乳清酸盐Amlodipine Orotate | Tier C · 观察 / 贸易 | - |
| 樟脑磺酸氨氯地平Amlodipine Camsylate | Tier C · 观察 / 贸易 | - |
| 马来酸氨氯地平Amlodipine Maleate | Tier C · 观察 / 贸易 | - |
| 米替福新Miltefosine | Tier C · 观察 / 贸易 | - |
| 枸橼酸莫沙必利Mosapride Citrate | Tier C · 观察 / 贸易 | - |
| CBL-0137 | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
2-aminoethan-1-ol→2-chloroacetyl chloride→2-(2-chloroacetamido)ethyl 2-chloroacetate→2-chloro-N-(2-hydroxyethyl)acetamide→morpholin-3-one→1-fluoro-4-nitrobenzene→4-(4-nitrophenyl)morpholin-3-one→4-(4-aminophenyl)morpholin-3-one→(S)-2-(oxiran-2-ylmethyl)isoindoline-1,3-dione→(R)-2-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione→(S)-2-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione→(S)-4-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one oxalate→5-chlorothiophene-2-carbonyl chloride
1-fluoro-3,5-dimethylbenzene→2,4-dichloro-1-fluoro-3,5-dimethylbenzene→2,4-dichloro-3-(dichloromethyl)-1-fluoro-5-(trichloromethyl)benzene→2,4-dichloro-5-fluoro-3-formylbenzoic acid→(Z)-2,4-dichloro-5-fluoro-3-((hydroxyimino)methyl)benzoic acid→2,4-dichloro-3-cyano-5-fluorobenzoyl chloride→(Z)-ethyl 3-(dimethylamino)acrylate→ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-(dimethylamino)acrylate→cyclopropanamine→ethyl 3-(cyclopropylamino)-2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)acrylate→ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate→7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid→(4aS,7aS)-octahydropyrrolo[3,4-b][1,4]oxazine→(E)-but-2-ene-1,4-diol→1-tosyl-2,5-dihydro-1H-pyrrole→3-tosyl-6-oxa-3-azabicyclo[3.1.0]hexane→2-aminoethan-1-ol→4-((2-hydroxyethyl)amino)-1-tosylpyrrolidin-3-ol→2-(N-(4-hydroxy-1-tosylpyrrolidin-3-yl)-4-methylphenylsulfonamido)ethyl 4-methylbenzenesulfonate→4,6-ditosyloctahydropyrrolo[3,4-b][1,4]oxazine→(4aS,7aS)-4,6-ditosyloctahydropyrrolo[3,4-b][1,4]oxazine
2-Aminoethanol→(2-chloro-1,1-diphenylethyl)benzene→2-[(triphenylmethyl)amino]ethan-1-ol→Ethyl 4-chloroacetoacetate→ethyl 3-oxo-4-{2-[(triphenylmethyl)amino]ethoxy}butanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-({2-[(triphenylmethyl)amino]ethoxy}methyl)-1,4-dihydropyridine-3,5-dicarboxylate
2-Aminoethanol→(2-chloro-1,1-diphenylethyl)benzene→2-[(triphenylmethyl)amino]ethan-1-ol→Ethyl 4-chloroacetoacetate→ethyl 3-oxo-4-{2-[(triphenylmethyl)amino]ethoxy}butanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-({2-[(triphenylmethyl)amino]ethoxy}methyl)-1,4-dihydropyridine-3,5-dicarboxylate
2-Aminoethanol→(2-chloro-1,1-diphenylethyl)benzene→2-[(triphenylmethyl)amino]ethan-1-ol→Ethyl 4-chloroacetoacetate→ethyl 3-oxo-4-{2-[(triphenylmethyl)amino]ethoxy}butanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-({2-[(triphenylmethyl)amino]ethoxy}methyl)-1,4-dihydropyridine-3,5-dicarboxylate
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 4-(4-Aminophenyl)morpholin -3-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | (S)-(+)-N-(2,3-Epoxypropyl)phthalimide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 5-Chlorothiophene-2-carboxylic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 5-Chlorothiophene-2-carbonyl chloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 2-[[(5S)-2-0x0-3-[4-(3-0xo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-1H-isoindole-1,3(2H)-dione Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 4-[4-[(5S)-5-(Aminomethyl)-2-0xo-3-oxazolidinyl]phenyl] -3-morpholinone hydrochloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。