← 返回专利悬崖列表
CAS 57-13-6
ureaCarbamideUreaIsourea
登记编号：AVAN-035、Tenofovir disoproxil phosphate-043、ROSU-047、OLMU-002、Ambroxol- 035、(V)805433-1-a
应用背景（按来源药适应症）
勃起功能障碍阿伐那非HIV感染拉米夫定/富马酸替诺福韦二吡呋酯慢性乙型肝炎拉米夫定/富马酸替诺福韦二吡呋酯HIV感染依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯高血压瑞舒伐他汀钙/非马沙坦钾三水合物血脂障碍瑞舒伐他汀钙/非马沙坦钾三水合物非小细胞肺癌奥莫替尼高血压瑞舒伐他汀钙/替米沙坦高脂血症瑞舒伐他汀钙/替米沙坦HIV感染恩曲他滨/盐酸利匹韦林/富马酸替诺福韦二吡呋酯慢性支气管炎罗红霉素/盐酸氨溴索支气管炎罗红霉素/盐酸氨溴索呼吸道感染罗红霉素/盐酸氨溴索肺炎罗红霉素/盐酸氨溴索气管炎罗红霉素/盐酸氨溴索细菌感染罗红霉素/盐酸氨溴索乙型肝炎磷酸替诺福韦二吡呋酯纯合子家族性高胆固醇血症瑞舒伐他汀钙杂合子家族性高胆固醇血症瑞舒伐他汀钙高脂蛋白血症Ⅲ型瑞舒伐他汀钙动脉粥样硬化瑞舒伐他汀钙II型高脂蛋白血症瑞舒伐他汀钙高胆固醇血症瑞舒伐他汀钙麻醉盐酸氨溴索咽炎盐酸氨溴索呼吸道疾病盐酸氨溴索支气管炎盐酸氨溴索帕金森病盐酸氨溴索帕金森综合征盐酸氨溴索特发性肺纤维化那米司特间质性肺疾病那米司特肺纤维化那米司特肌炎那米司特系统性硬皮病那米司特肌病那米司特
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 阿伐那非Avanafil | Tier C · 观察 / 贸易 | 2028 |
| 拉米夫定/富马酸替诺福韦二吡呋酯Lamivudine/Tenofovir Disoproxil Fumarate | Tier C · 观察 / 贸易 | - |
| 依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate | Tier C · 观察 / 贸易 | - |
| 瑞舒伐他汀钙/非马沙坦钾三水合物Fimasartan potassium trihydrate/Rosuvastatin calcium | Tier C · 观察 / 贸易 | - |
| 奥莫替尼Olmutinib | Tier C · 观察 / 贸易 | - |
| 瑞舒伐他汀钙/替米沙坦Rosuvastatin Calcium/Telmisartan | Tier C · 观察 / 贸易 | - |
| 恩曲他滨/盐酸利匹韦林/富马酸替诺福韦二吡呋酯Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil Fumarate | Tier B · 提前布局 | - |
| 罗红霉素/盐酸氨溴索Roxithromycin/Ambroxol Hydrochloride | Tier C · 观察 / 贸易 | - |
| 磷酸替诺福韦二吡呋酯Tenofovir disoproxil phosphate | Tier C · 观察 / 贸易 | - |
| 瑞舒伐他汀钙Rosuvastatin Calcium | Tier B · 提前布局 | - |
| 盐酸氨溴索Ambroxol Hydrochloride | Tier C · 观察 / 贸易 | - |
| 那米司特Nerandomilast | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(S)-pyrrolidin-2-ylmethanol→ethyl (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate→pyrimidin-2-ylmethanamine→ethyl 2-cyanoacetate→urea→ethyl (E)-2-cyano-3-ureidoacrylate→ethyl 6-amino-2-oxo-1,2-dihydropyrimidine-5-carboxylate→2-chloro-4-(chloromethyl)-1-methoxybenzene→ethyl 6-((3-chloro-4-methoxybenzyl)amino)-2-oxo-1,2-dihydropyrimidine-5-carboxylate
(R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol→(Diethoxyphosphoryl)methyl 4-methylbenzene-1-sulfonate→(R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine→Carbamide→Thiocarbamide→Guanidine→Ethoxy(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→(Ethylsulfanyl)(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→(Ethylamino)(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate
(R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol→(Diethoxyphosphoryl)methyl 4-methylbenzene-1-sulfonate→(R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine→Carbamide→Thiocarbamide→Guanidine→Ethoxy(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→(Ethylsulfanyl)(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→(Ethylamino)(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate
4-fluorobenzaldehyde→N-(5-((diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→N-(4-(4-fluorophenyl)-5-((E)-2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→methyl 4-methyl-3-oxopentanoate→urea→methyl 4-(4-fluorophenyl)-6-isopropyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate→methyl 4-(4-fluorophenyl)-2-hydroxy-6-isopropylpyrimidine-5-carboxylate→N-methylmethanesulfonamide→methyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidine-5-carboxylate→N-(4-(4-fluorophenyl)-5-(hydroxymethyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→N-(5-(bromomethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→tert-butyl (4S,6S)-6-formyl-2,2-dimethyl-1,3-dioxane-4-carboxylate→tert-butyl (4S,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxane-4-carboxylate
Methyl 3-aminothiophene-2-carboxylate→Urea→Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione→2,4-dichlorothieno[3,2-d]pyrimidine→3-nitrophenol→2-chloro-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidine→4-(4-methylpiperazin-1-yl)aniline→N-(4-(4-methylpiperazin-1-yl)phenyl)-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidin-2-amine→4-(3-aminophenoxy)-N-(4-(4-methylpiperazin-1-yl)phenyl)thieno[3,2-d]pyrimidin-2-amine→Acryloyl chloride
本站可供应的对应中间体
目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。