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磷酸依米他韦
Tier C · 观察 / 贸易Emitasvir Phosphate
宜昌东阳光长江药业股份有限公司
原研
2020
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：NS5A
商品名：东卫恩
适应症（已批准）：丙型肝炎
各地区研发/上市状态
美国
-
欧盟
-
中国
批准上市
2020-12-21
日本
-
生产该 API 的工厂3
口径：平台供应网络（富通询价明细 + 产品主档）中登记生产该品种的工厂（在产口径），按报价活跃度排序；快照不含成本与客户信息。
已收录 3 家在产工厂名单，登录后可见（工厂信息不对未登录访客展示）。
登录查看工厂名单 →合成路线与中间体4 routes
原研路线 × 0优化路线（非专利）× 4工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 1步骤 6 · 总收率 230.40mg(Emitasvir Phosphate (API))
Emitasvir Phosphate-0011575-37-7Emitasvir Phosphate-00215761-39-4Emitasvir Phosphate-0031208007-67-3Emitasvir Phosphate-0041208009-37-3Emitasvir Phosphate-0051959593-66-8Emitasvir Phosphate-0061959593-27-1Emitasvir Phosphate-0071959593-25-9Emitasvir Phosphate-008—Emitasvir Phosphate-00974761-42-5Emitasvir Phosphate-0101959593-23-7API · 磷酸依米他韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Emitasvir Phosphate-001 | 1575-37-7 | 2-Amino-4-bromophenylamine |
| Emitasvir Phosphate-002 | 15761-39-4 | N-Boc-L-proline |
| Emitasvir Phosphate-003 | 1208007-67-3 | tert-Butyl 2(S)-(5-bromo-2-benzimidazolyl)pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-004 | 1208009-37-3 | tert-Butyl (2S)-2-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-005 | 1959593-66-8 | tert-Butyl (2S)-2-[4-(4-[(1S,4R)-8-[(trifluoromethanesulfonyl)oxy]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-006 | 1959593-27-1 | tert-Butyl (2S)-2-(4-[4-[(1S,4R)-8-[2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-benzimidazol-5-yl]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl]-1H-imidazol-2-yl)pyrrolidine-1-carboxyla te |
| Emitasvir Phosphate-007 | 1959593-25-9 | 2-[(2S)-Pyrrolidin-2-yl]-5-[(1R,4S)-8-(4-[2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl]phenyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-1H-benzimidazole |
| Emitasvir Phosphate-008 | - | 2-[(2S)-Pyrrolidin-2-yl]-5-[(1R,4S)-8-(4-[2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-1H-benzimidazole tetrahydrogen chloride |
| Emitasvir Phosphate-009 | 74761-42-5 | N-(Methoxycarbonyl)-L-valine |
| Emitasvir Phosphate-010 | 1959593-23-7 | Methyl [(2S)-1-[(2S)-2-[5-[(1R,4S)-8-(4-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-4-yl]phenyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-1H-benzimi dazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate |
优化Route 2步骤 10 · 总收率 697mg(Emitasvir Phosphate-005)
Emitasvir Phosphate-00215761-39-4Emitasvir Phosphate-0051959593-66-8Emitasvir Phosphate-01199-90-1Emitasvir Phosphate-01299-73-0Emitasvir Phosphate-013128120-93-4Emitasvir Phosphate-0141007882-04-3Emitasvir Phosphate-015—Emitasvir Phosphate-0161401068-73-2Emitasvir Phosphate-0171560642-34-3Emitasvir Phosphate-018106-51-4Emitasvir Phosphate-019542-92-7Emitasvir Phosphate-0201200-89-1Emitasvir Phosphate-0213090-47-9Emitasvir Phosphate-02216144-91-5API · 磷酸依米他韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Emitasvir Phosphate-002 | 15761-39-4 | N-Boc-L-proline |
| Emitasvir Phosphate-005 | 1959593-66-8 | tert-Butyl (2S)-2-[4-(4-[(1S,4R)-8-[(trifluoromethanesulfonyl)oxy]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-011 | 99-90-1 | 1-Acetyl-4-bromobenzene |
| Emitasvir Phosphate-012 | 99-73-0 | 4'-Bromophenacyl bromide |
| Emitasvir Phosphate-013 | 128120-93-4 | 2-[2-(4-Bromophenyl)-2-oxoethyl] 1-tert-butyl (2S)-pyrrolidine-1,2-dicarboxylate |
| Emitasvir Phosphate-014 | 1007882-04-3 | (S)-tert-Butyl 2-(5-(4-bromophenyl)-1h-imidazol-2-yl)pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-015 | - | tert-Butyl (2S)-2-[4-[4-(3,3,4,4-tetramethylborolan-1-yl)phenyl]-1H-imidazol-2-yl]pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-016 | 1401068-73-2 | 1,2,3,4-Tetrahydro-1,4-methanonaphthalene-5,8-diyl bis(trifluoromethanesulfonate) |
| Emitasvir Phosphate-017 | 1560642-34-3 | tert-Butyl (2S)-2-[4-(4-[8-[(trifluoromethanesulfonyl)oxy]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-018 | 106-51-4 | Quinone |
| Emitasvir Phosphate-019 | 542-92-7 | Cyclopenta-1,3-diene |
| Emitasvir Phosphate-020 | 1200-89-1 | Tricyclo[6.2.1.0,2,7]undeca-4,9-diene-3,6-dione |
| Emitasvir Phosphate-021 | 3090-47-9 | 1,4-Dihydro-1,4-methanonaphthalene-5,8-diol |
| Emitasvir Phosphate-022 | 16144-91-5 | 1,2,3,4-Tetrahydro-1,4-methanonaphthalene-5,8-diol |
优化Route 3步骤 5 · 总收率 31.6g(Emitasvir Phosphate-005)
Emitasvir Phosphate-0051959593-66-8Emitasvir Phosphate-015—Emitasvir Phosphate-02216144-91-5Emitasvir Phosphate-02316144-90-4Emitasvir Phosphate-0242379279-46-4Emitasvir Phosphate-0252765664-85-3Emitasvir Phosphate-0262765664-73-9API · 磷酸依米他韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Emitasvir Phosphate-005 | 1959593-66-8 | tert-Butyl (2S)-2-[4-(4-[(1S,4R)-8-[(trifluoromethanesulfonyl)oxy]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-015 | - | tert-Butyl (2S)-2-[4-[4-(3,3,4,4-tetramethylborolan-1-yl)phenyl]-1H-imidazol-2-yl]pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-022 | 16144-91-5 | 1,2,3,4-Tetrahydro-1,4-methanonaphthalene-5,8-diol |
| Emitasvir Phosphate-023 | 16144-90-4 | 1,2,3,4-Tetrahydro-1,4-methanonaphthalene-5,8-diyl diacetate |
| Emitasvir Phosphate-024 | 2379279-46-4 | (1R,4S)-8-Hydroxy-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl acetate |
| Emitasvir Phosphate-025 | 2765664-85-3 | (1R,4S)-8-[(Trifluoromethanesulfonyl)oxy]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl acetate |
| Emitasvir Phosphate-026 | 2765664-73-9 | tert-Butyl (2S)-2-(4-[4-[(1S,4R)-8-hydroxy-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl]-1H-imidazol-2-yl)pyrrolidine-1-carboxylate |
优化Route 4步骤 2 · 总收率 4.9g(Emitasvir Phosphate-029)
Emitasvir Phosphate-02216144-91-5Emitasvir Phosphate-02779-03-8Emitasvir Phosphate-0282361304-37-0Emitasvir Phosphate-0292365512-64-5API · 磷酸依米他韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Emitasvir Phosphate-022 | 16144-91-5 | 1,2,3,4-Tetrahydro-1,4-methanonaphthalene-5,8-diol |
| Emitasvir Phosphate-027 | 79-03-8 | Propanoyl chloride |
| Emitasvir Phosphate-028 | 2361304-37-0 | 1,2,3,4-Tetrahydro-1,4-methanonaphthalene-5,8-diyl dipropanoate |
| Emitasvir Phosphate-029 | 2365512-64-5 | (1S,4R)-8-Hydroxy-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl propanoate |
常见问题（FAQ）
磷酸依米他韦的适应症有哪些？
已批准的适应症包括：丙型肝炎。
磷酸依米他韦的专利什么时候到期？
磷酸依米他韦的专利到期年暂无公开口径，本页会在数据管道核实后更新。
磷酸依米他韦有几条合成路线？
本站收录 4 条合成路线，最短路线 2 步、总收率 4.9g(Emitasvir Phosphate-029)。每条路线的中间体均带登记编号与 CAS 号。
磷酸依米他韦的关键中间体在哪里可以采购？
磷酸依米他韦路线中的中间体均已建立 CAS 档案，可直接按 CAS 发起询价，需求会进入供应网络撮合池。
如何获取磷酸依米他韦中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22