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CAS 74761-42-5
(methoxycarbonyl)-D-valineN-(Methoxycarbonyl)-L-valine
登记编号：ELBA-014、Emitasvir Phosphate-009、RAVI-009
应用背景（按来源药适应症）
丙型肝炎艾尔巴韦慢性丙型肝炎艾尔巴韦肝功能衰退艾尔巴韦肾功能不全艾尔巴韦病毒性肝炎艾尔巴韦丙型肝炎磷酸依米他韦肾功能不全磷酸依米他韦肝功能衰退磷酸依米他韦慢性丙型肝炎磷酸依米他韦丙型肝炎盐酸拉维达韦病毒感染盐酸拉维达韦慢性丙型肝炎盐酸拉维达韦
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
3-bromophenol→3-bromophenyl acetate→1-(4-bromo-2-hydroxyphenyl)ethan-1-one→(4-bromophenyl)hydrazine→(E)-5-bromo-2-(1-(2-(4-bromophenyl)hydrazineylidene)ethyl)phenol→5-bromo-2-(5-bromo-1H-indol-2-yl)phenol→(dibromomethyl)benzene→3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→6-phenyl-3,10-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indole→tert-butyl (S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylate→di-tert-butyl 2,2'-((6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-4,2-diyl))(2S,2'S)-bis(pyrrolidine-1-carboxylate)→(S)-6-phenyl-3,10-bis(2-((S)-pyrrolidin-2-yl)-1H-imidazol-4-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indole→(methoxycarbonyl)-D-valine
3-bromophenol→tert-butyl (S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylate→(S)-6-phenyl-3,10-bis(2-((S)-pyrrolidin-2-yl)-1H-imidazol-4-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indole→(methoxycarbonyl)-D-valine→2-(2,5-dibromophenyl)acetic acid→3-bromophenyl 2-(2,5-dibromophenyl)acetate→1-(4-bromo-2-hydroxyphenyl)-2-(2,5-dibromophenyl)ethan-1-one→5-bromo-2-(2-(2,5-dibromophenyl)-1-iminoethyl)phenol→((N-((1S,2S)-1,2-diphenyl-2-((3-phenylpropyl)amino)ethyl)-4-methylphenyl)sulfonamido)ruthenium(II) chloride→(R)-2-(1-amino-2-(2,5-dibromophenyl)ethyl)-5-bromophenol→(R)-5-bromo-2-(5-bromoindolin-2-yl)phenol→(6S,12aR)-3,10-dibromo-6-phenyl-12,12a-dihydro-6H-benzo[5,6][1,3]oxazino[3,4-a]indole→(S)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole→di-tert-butyl 2,2'-(((S)-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-4,2-diyl))(2S,2'S)-bis(pyrrolidine-1-carboxylate)
tert-butyl (S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylate→(methoxycarbonyl)-D-valine→tert-butyl (S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate→tert-butyl (S)-2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate→tert-butyl (S)-2-(5-bromo-4-chloro-1H-imidazol-2-yl)pyrrolidine-1-carboxylate→tert-butyl (S)-2-(4-chloro-1H-imidazol-2-yl)pyrrolidine-1-carboxylate→(S)-4-chloro-2-(pyrrolidin-2-yl)-1H-imidazole→methyl ((R)-1-((S)-2-(4-chloro-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate→(S)-6-phenyl-3,10-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indole
2-Amino-4-bromophenylamine→N-Boc-L-proline→tert-Butyl 2(S)-(5-bromo-2-benzimidazolyl)pyrrolidine-1-carboxylate→tert-Butyl (2S)-2-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]pyrrolidine-1-carboxylate→tert-Butyl (2S)-2-[4-(4-[(1S,4R)-8-[(trifluoromethanesulfonyl)oxy]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate→tert-Butyl (2S)-2-(4-[4-[(1S,4R)-8-[2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-benzimidazol-5-yl]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl]-1H-imidazol-2-yl)pyrrolidine-1-carboxyla te→2-[(2S)-Pyrrolidin-2-yl]-5-[(1R,4S)-8-(4-[2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl]phenyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-1H-benzimidazole→2-[(2S)-Pyrrolidin-2-yl]-5-[(1R,4S)-8-(4-[2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-1H-benzimidazole tetrahydrogen chloride→N-(Methoxycarbonyl)-L-valine→Methyl [(2S)-1-[(2S)-2-[5-[(1R,4S)-8-(4-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-4-yl]phenyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-1H-benzimi dazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
本站可供应的对应中间体
目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。