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CAS 15761-39-4
(S)-1-(tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acidN-Boc-L-proline(S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid(2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
登记编号：Tamsulosin Hydrochloride-087、Emitasvir Phosphate-002、RAVI-005、Atosiban-133、(XIII)692039-1-b、(Xb)1062329-1-b
应用背景（按来源药适应症）
勃起功能障碍他达拉非/坦洛新前列腺增生他达拉非/坦洛新下尿路症状琥珀酸索利那新/盐酸坦洛新前列腺增生琥珀酸索利那新/盐酸坦洛新膀胱过度活动症琥珀酸索利那新/盐酸坦洛新药物相关的副作用和不良反应琥珀酸索利那新/盐酸坦洛新膀胱颈梗阻琥珀酸索利那新/盐酸坦洛新前列腺增生度他雄胺/盐酸坦洛新前列腺增生盐酸坦洛新泌尿系统感染盐酸坦洛新尿潴留盐酸坦洛新腹股沟疝盐酸坦洛新排尿功能障碍盐酸坦洛新下尿路症状盐酸坦洛新丙型肝炎磷酸依米他韦肾功能不全磷酸依米他韦肝功能衰退磷酸依米他韦慢性丙型肝炎磷酸依米他韦丙型肝炎盐酸拉维达韦病毒感染盐酸拉维达韦慢性丙型肝炎盐酸拉维达韦产科分娩（早产）阿托西班醋酸盐早产（孕37周前）阿托西班醋酸盐子宫内膜异位症阿托西班醋酸盐冠状病毒感染TRV-120027新型冠状病毒感染TRV-120027急性失代偿性心力衰竭TRV-120027肾脏疾病TRV-120027心脏衰竭TRV-120027
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 他达拉非/坦洛新Tadalafil/Tamsulosin | Tier C · 观察 / 贸易 | - |
| 琥珀酸索利那新/盐酸坦洛新Solifenacin Succinate/Tamsulosin Hydrochloride | Tier C · 观察 / 贸易 | - |
| 度他雄胺/盐酸坦洛新Dutasteride/Tamsulosin Hydrochloride | Tier C · 观察 / 贸易 | - |
| 盐酸坦洛新Tamsulosin Hydrochloride | Tier C · 观察 / 贸易 | - |
| 磷酸依米他韦Emitasvir Phosphate | Tier C · 观察 / 贸易 | - |
| 盐酸拉维达韦Ravidasvir Hydrochloride | Tier C · 观察 / 贸易 | - |
| 阿托西班醋酸盐Atosiban acetate | Tier C · 观察 / 贸易 | - |
| TRV-120027 | Tier C · 观察 / 贸易 | - |
| Dazdotuftide | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
5-Acetyl-2-methoxybenzene-1-sulfonamide→2-(2-Ethoxyphenoxy)ethylamine→Tamsulosin Hydrochloride-085→(2R)-Hydroxy(phenyl)acetic acid 5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzene-1-sulfonamide→(S)-1-(tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid→Carbonochloridic acid ethyl ester→Ethoxycarbonyl 1-(tert-butoxycarbonyl)-L-prolinate→2-Methoxydibenzo[b,d]furan-3-amine→tert-Butyl (2S)-2-[(2-methoxydibenzo[b,d]furan-3-yl)carbamoyl]pyrrolidine-1-carboxylate→N-(2-Methoxydibenzo[b,d]furan-3-yl)-L-prolinamide
5-Acetyl-2-methoxybenzene-1-sulfonamide→2-(2-Ethoxyphenoxy)ethylamine→Tamsulosin Hydrochloride-085→(2R)-Hydroxy(phenyl)acetic acid 5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzene-1-sulfonamide→(S)-1-(tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid→Carbonochloridic acid ethyl ester→Ethoxycarbonyl 1-(tert-butoxycarbonyl)-L-prolinate→2-Methoxydibenzo[b,d]furan-3-amine→tert-Butyl (2S)-2-[(2-methoxydibenzo[b,d]furan-3-yl)carbamoyl]pyrrolidine-1-carboxylate→N-(2-Methoxydibenzo[b,d]furan-3-yl)-L-prolinamide
5-Acetyl-2-methoxybenzene-1-sulfonamide→2-(2-Ethoxyphenoxy)ethylamine→Tamsulosin Hydrochloride-085→(2R)-Hydroxy(phenyl)acetic acid 5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzene-1-sulfonamide→(S)-1-(tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid→Carbonochloridic acid ethyl ester→Ethoxycarbonyl 1-(tert-butoxycarbonyl)-L-prolinate→2-Methoxydibenzo[b,d]furan-3-amine→tert-Butyl (2S)-2-[(2-methoxydibenzo[b,d]furan-3-yl)carbamoyl]pyrrolidine-1-carboxylate→N-(2-Methoxydibenzo[b,d]furan-3-yl)-L-prolinamide
5-Acetyl-2-methoxybenzene-1-sulfonamide→2-(2-Ethoxyphenoxy)ethylamine→Tamsulosin Hydrochloride-085→(2R)-Hydroxy(phenyl)acetic acid 5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzene-1-sulfonamide→(S)-1-(tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid→Carbonochloridic acid ethyl ester→Ethoxycarbonyl 1-(tert-butoxycarbonyl)-L-prolinate→2-Methoxydibenzo[b,d]furan-3-amine→tert-Butyl (2S)-2-[(2-methoxydibenzo[b,d]furan-3-yl)carbamoyl]pyrrolidine-1-carboxylate→N-(2-Methoxydibenzo[b,d]furan-3-yl)-L-prolinamide
2-Amino-4-bromophenylamine→N-Boc-L-proline→tert-Butyl 2(S)-(5-bromo-2-benzimidazolyl)pyrrolidine-1-carboxylate→tert-Butyl (2S)-2-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]pyrrolidine-1-carboxylate→tert-Butyl (2S)-2-[4-(4-[(1S,4R)-8-[(trifluoromethanesulfonyl)oxy]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate→tert-Butyl (2S)-2-(4-[4-[(1S,4R)-8-[2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-benzimidazol-5-yl]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl]-1H-imidazol-2-yl)pyrrolidine-1-carboxyla te→2-[(2S)-Pyrrolidin-2-yl]-5-[(1R,4S)-8-(4-[2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl]phenyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-1H-benzimidazole→2-[(2S)-Pyrrolidin-2-yl]-5-[(1R,4S)-8-(4-[2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-1H-benzimidazole tetrahydrogen chloride→N-(Methoxycarbonyl)-L-valine→Methyl [(2S)-1-[(2S)-2-[5-[(1R,4S)-8-(4-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-4-yl]phenyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-1H-benzimi dazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
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