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盐酸卡替洛尔/拉坦前列素
Tier C · 观察 / 贸易Carteolol Hydrochloride/Latanoprost
大冢制药株式会社
原研
2016
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：PTGFR、ADRB2、ADRB1
商品名：Mikeluna
适应症（已批准）：高眼压、青光眼
各地区研发/上市状态
美国
-
欧盟
-
中国
临床三期
2022-09-27
日本
批准上市
2016-09-28
生产该 API 的工厂9
口径：平台供应网络（富通询价明细 + 产品主档）中登记生产该品种的工厂（在产口径），按报价活跃度排序；快照不含成本与客户信息。
已收录 9 家在产工厂名单，登录后可见（工厂信息不对未登录访客展示）。
登录查看工厂名单 →合成路线与中间体7 routes
原研路线 × 1优化路线（非专利）× 6工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 8 · 总收率 0.19 g
LATA-00131752-99-5LATA-00238754-71-1LATA-00341162-19-0LATA-00441639-72-9LATA-00541639-73-0LATA-006145667-74-9LATA-007145667-75-0LATA-008352276-28-9LATA-00917814-85-6LATA-01041639-83-2LATA-01175-30-9API · 盐酸卡替洛尔/拉坦前列素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| LATA-001 | 31752-99-5 | (3aR,4S,5R,6aS)-4-(hydroxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate |
| LATA-002 | 38754-71-1 | (3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate |
| LATA-003 | 41162-19-0 | dimethyl (2-oxo-4-phenylbutyl)phosphonate |
| LATA-004 | 41639-72-9 | (3aR,4R,5R,6aS)-2-oxo-4-((E)-3-oxo-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate |
| LATA-005 | 41639-73-0 | (3aR,4R,5R,6aS)-4-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate |
| LATA-006 | 145667-74-9 | (3aR,4R,5R,6aS)-4-((R)-3-hydroxy-5-phenylpentyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate |
| LATA-007 | 145667-75-0 | (3aR,4R,5R,6aS)-5-hydroxy-4-((R)-3-hydroxy-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2-one |
| LATA-008 | 352276-28-9 | (3aR,4R,5R,6aS)-4-((R)-3-hydroxy-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2,5-diol |
| LATA-009 | 17814-85-6 | (4-carboxybutyl)triphenylphosphonium bromide |
| LATA-010 | 41639-83-2 | (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoic acid |
| LATA-011 | 75-30-9 | 2-iodopropane |
优化Route 1步骤 4 · 总收率 /
Carteolol Hydrochloride-001108-46-3Carteolol Hydrochloride-002504-02-9Carteolol Hydrochloride-0035220-49-5Carteolol Hydrochloride-00479-10-7Carteolol Hydrochloride-0055057-12-5Carteolol Hydrochloride-00630389-33-4API · 盐酸卡替洛尔/拉坦前列素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Carteolol Hydrochloride-001 | 108-46-3 | Benzene-1,3-diol |
| Carteolol Hydrochloride-002 | 504-02-9 | 1,3-Cyclohexanedione |
| Carteolol Hydrochloride-003 | 5220-49-5 | 3-Aminocyclohex-2-en-1-one |
| Carteolol Hydrochloride-004 | 79-10-7 | 2-Propenoic acid |
| Carteolol Hydrochloride-005 | 5057-12-5 | 1,2,3,4,5,6,7,8-Octahydroquinoline-2,5-dione |
| Carteolol Hydrochloride-006 | 30389-33-4 | 5-Hydroxy-1,2,3,4-tetrahydroquinolin-2-one |
优化Route 2步骤 5 · 总收率 /
Carteolol Hydrochloride-00751781-14-7Carteolol Hydrochloride-01051781-13-6Carteolol Hydrochloride-008252267-77-9Carteolol Hydrochloride-00630389-33-4Carteolol Hydrochloride-01296-24-2Carteolol Hydrochloride-011106-89-8Carteolol Hydrochloride-0133132-64-7Carteolol Hydrochloride-00975-64-9API · 盐酸卡替洛尔/拉坦前列素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Carteolol Hydrochloride-007 | 51781-14-7 | 5-(oxiran-2-ylmethoxy)-1,2,3,4-tetrahydroquinolin-2-one |
| Carteolol Hydrochloride-010 | 51781-13-6 | 5-(3-chloro-2-hydroxypropoxy)-1,2,3,4-tetrahydroquinolin-2-one |
| Carteolol Hydrochloride-008 | 252267-77-9 | decahydroquinoline-2,5-dione |
| Carteolol Hydrochloride-006 | 30389-33-4 | 5-Hydroxy-1,2,3,4-tetrahydroquinolin-2-one |
| Carteolol Hydrochloride-012 | 96-24-2 | (+/-)-2,3-Dihydroxychloropropane |
| Carteolol Hydrochloride-011 | 106-89-8 | (+/-)-2-(Chloromethyl)oxirane |
| Carteolol Hydrochloride-013 | 3132-64-7 | 1-Bromo-2,3-epoxypropane |
| Carteolol Hydrochloride-009 | 75-64-9在售 | 1,1-Dimethylethylamine |
优化Route 3步骤 5 · 总收率 /
Carteolol Hydrochloride-0141138-80-3Carteolol Hydrochloride-015506-59-2Carteolol Hydrochloride-016167303-60-8Carteolol Hydrochloride-0171857-19-8Carteolol Hydrochloride-01879-09-4Carteolol Hydrochloride-0191158271-30-7Carteolol Hydrochloride-020529-28-2Carteolol Hydrochloride-0211927901-90-3Carteolol Hydrochloride-0221927901-84-5API · 盐酸卡替洛尔/拉坦前列素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Carteolol Hydrochloride-014 | 1138-80-3在售 | 2-(Benzyloxycarbonylamino)acetic acid |
| Carteolol Hydrochloride-015 | 506-59-2在售 | Dimethylamine hydrochloride |
| Carteolol Hydrochloride-016 | 167303-60-8 | Benzyl [2-(dimethylamino)-2-oxoethyl]carbamate |
| Carteolol Hydrochloride-017 | 1857-19-8 | N,N-Dimethylglycinamide |
| Carteolol Hydrochloride-018 | 79-09-4在售 | Carboxyethane |
| Carteolol Hydrochloride-019 | 1158271-30-7 | N-[2-(Dimethylamino)-2-oxoethyl]propanamide |
| Carteolol Hydrochloride-020 | 529-28-2 | 1-Iodo-2-methoxybenzene |
| Carteolol Hydrochloride-021 | 1927901-90-3 | N-[2-(Dimethylamino)-2-oxoethyl]-3-(2-methoxyphenyl)propanamide |
| Carteolol Hydrochloride-022 | 1927901-84-5 | 2-(5-Methoxy-2-oxo-3,4-dihydroquinolin-1(2H)-yl)-N,N-dimethylacetamide |
优化Route 2步骤 10 · 总收率 /
LATA-008352276-28-9LATA-00917814-85-6LATA-01041639-83-2LATA-01175-30-9LATA-012591-87-7LATA-013122-97-4LATA-01498088-55-2LATA-0151379822-84-0LATA-016474944-31-5LATA-017876953-73-0LATA-018110-02-1LATA-019—LATA-020—LATA-0211644539-27-4LATA-0221644539-31-0API · 盐酸卡替洛尔/拉坦前列素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| LATA-008 | 352276-28-9 | (3aR,4R,5R,6aS)-4-((R)-3-hydroxy-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2,5-diol |
| LATA-009 | 17814-85-6 | (4-carboxybutyl)triphenylphosphonium bromide |
| LATA-010 | 41639-83-2 | (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoic acid |
| LATA-011 | 75-30-9 | 2-iodopropane |
| LATA-012 | 591-87-7 | allyl acetate |
| LATA-013 | 122-97-4 | 3-phenylpropan-1-ol |
| LATA-014 | 98088-55-2 | (S)-1-phenylhex-5-en-3-ol |
| LATA-015 | 1379822-84-0 | (S)-tert-butyldimethyl((1-phenylhex-5-en-3-yl)oxy)silane |
| LATA-016 | 474944-31-5 | (S)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentan-1-ol |
| LATA-017 | 876953-73-0 | (S)-tert-butyl((1-iodo-5-phenylpentan-3-yl)oxy)dimethylsilane |
| LATA-018 | 110-02-1 | thiophene |
| LATA-019 | - | - |
| LATA-020 | - | (3aR,6aS)-2-methoxy-3,3a,6,6a-tetrahydro-2H-cyclopenta[b]furan-5-carbaldehyde |
| LATA-021 | 1644539-27-4 | tert-butyl(((3R)-1-((3aR,4R,6aS,Z)-2-methoxy-5-(((trimethylsilyl)oxy)methylene)hexahydro-2H-cyclopenta[b]furan-4-yl)-5-phenylpentan-3-yl)oxy)dimethylsilane |
| LATA-022 | 1644539-31-0 | (3aR,4R,5R,6aS)-4-((R)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentyl)-2-methoxyhexahydro-2H-cyclopenta[b]furan-5-ol |
优化Route 3步骤 8 · 总收率 /
LATA-00341162-19-0LATA-00917814-85-6LATA-01041639-83-2LATA-02364091-14-1LATA-0241240483-13-9LATA-0251240483-14-0LATA-0261240483-20-8LATA-0271240483-21-9LATA-0281240483-22-0LATA-0291240483-23-1LATA-03067-63-0API · 盐酸卡替洛尔/拉坦前列素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| LATA-003 | 41162-19-0 | dimethyl (2-oxo-4-phenylbutyl)phosphonate |
| LATA-009 | 17814-85-6 | (4-carboxybutyl)triphenylphosphonium bromide |
| LATA-010 | 41639-83-2 | (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoic acid |
| LATA-023 | 64091-14-1 | (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-2-oxohexahydro-2H-cyclopenta[b]furan-4-carbaldehyde |
| LATA-024 | 1240483-13-9 | (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((E)-3-oxo-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one |
| LATA-025 | 1240483-14-0 | (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one |
| LATA-026 | 1240483-20-8 | (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((R)-3-hydroxy-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2-one |
| LATA-027 | 1240483-21-9 | (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((R)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2-one |
| LATA-028 | 1240483-22-0 | (3aR,4R,5R,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((R)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2-ol |
| LATA-029 | 1240483-23-1 | (Z)-7-((1R,2R,3R,5S)-3-((tert-butyldimethylsilyl)oxy)-2-((R)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentyl)-5-hydroxycyclopentyl)hept-5-enoic acid |
| LATA-030 | 67-63-0 | propan-2-ol |
优化Route 4步骤 7 · 总收率 0.7 g
LATA-007145667-75-0LATA-00917814-85-6LATA-01041639-83-2LATA-01175-30-9LATA-03161263-22-7LATA-032856453-29-7LATA-033141074-03-5LATA-0341652582-57-4LATA-0351261926-71-9API · 盐酸卡替洛尔/拉坦前列素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| LATA-007 | 145667-75-0 | (3aR,4R,5R,6aS)-5-hydroxy-4-((R)-3-hydroxy-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2-one |
| LATA-009 | 17814-85-6 | (4-carboxybutyl)triphenylphosphonium bromide |
| LATA-010 | 41639-83-2 | (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoic acid |
| LATA-011 | 75-30-9 | 2-iodopropane |
| LATA-031 | 61263-22-7 | (3aR,4R,5R,6aS)-4-((3R)-5-phenyl-3-((tetrahydro-2H-pyran-2-yl)oxy)pentyl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-one |
| LATA-032 | 856453-29-7 | (3aR,4R,5R,6aS)-4-((3R)-5-phenyl-3-((tetrahydro-2H-pyran-2-yl)oxy)pentyl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-ol |
| LATA-033 | 141074-03-5 | (Z)-7-((1R,2R,3R,5S)-5-hydroxy-2-((3R)-5-phenyl-3-((tetrahydro-2H-pyran-2-yl)oxy)pentyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)hept-5-enoic acid |
| LATA-034 | 1652582-57-4 | (8aR,9R,10R,11aS,Z)-9-((3R)-5-phenyl-3-((tetrahydro-2H-pyran-2-yl)oxy)pentyl)-10-((tetrahydro-2H-pyran-2-yl)oxy)-4,5,8,8a,9,10,11,11a-octahydrocyclopenta[b]oxecin-2(3H)-one |
| LATA-035 | 1261926-71-9 | (8aR,9R,10R,11aS,Z)-10-hydroxy-9-((R)-3-hydroxy-5-phenylpentyl)-4,5,8,8a,9,10,11,11a-octahydrocyclopenta[b]oxecin-2(3H)-one |
常见问题（FAQ）
盐酸卡替洛尔/拉坦前列素的适应症有哪些？
已批准的适应症包括：高眼压、青光眼。
盐酸卡替洛尔/拉坦前列素的专利什么时候到期？
盐酸卡替洛尔/拉坦前列素的专利到期年暂无公开口径，本页会在数据管道核实后更新。
盐酸卡替洛尔/拉坦前列素有几条合成路线？
本站收录 7 条合成路线，最短路线 4 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
盐酸卡替洛尔/拉坦前列素的关键中间体在哪里可以采购？
盐酸卡替洛尔/拉坦前列素的多条路线中间体已挂接 CAS 档案，其中 4 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取盐酸卡替洛尔/拉坦前列素中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22