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CAS 1138-80-3
2-(Benzyloxycarbonylamino)acetic acid2-(((benzyloxy)carbonyl)amino)acetic acid
登记编号：Carteolol Hydrochloride-014、(XVIa)700647-1-b、TROFIN-003
应用背景（按来源药适应症）
高眼压盐酸卡替洛尔/拉坦前列素青光眼盐酸卡替洛尔/拉坦前列素开角型青光眼盐酸卡替洛尔/拉坦前列素高血压盐酸卡替洛尔高眼压盐酸卡替洛尔青光眼盐酸卡替洛尔心绞痛盐酸卡替洛尔心律失常盐酸卡替洛尔蠕形螨性睑缘炎洛替拉纳螨虫感染洛替拉纳莱姆病洛替拉纳酒渣鼻洛替拉纳睑板腺功能障碍洛替拉纳Rett综合征Trofinetide脑震荡Trofinetide脑损伤Trofinetide脆性X染色体综合征Trofinetide创伤性脑损伤Trofinetide
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 盐酸卡替洛尔/拉坦前列素Carteolol Hydrochloride/Latanoprost | Tier C · 观察 / 贸易 | - |
| 盐酸卡替洛尔Carteolol Hydrochloride | Tier C · 观察 / 贸易 | - |
| 洛替拉纳Lotilaner | Tier C · 观察 / 贸易 | - |
| Trofinetide | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
2-(Benzyloxycarbonylamino)acetic acid→Dimethylamine hydrochloride→Benzyl [2-(dimethylamino)-2-oxoethyl]carbamate→N,N-Dimethylglycinamide→Carboxyethane→N-[2-(Dimethylamino)-2-oxoethyl]propanamide→1-Iodo-2-methoxybenzene→N-[2-(Dimethylamino)-2-oxoethyl]-3-(2-methoxyphenyl)propanamide→2-(5-Methoxy-2-oxo-3,4-dihydroquinolin-1(2H)-yl)-N,N-dimethylacetamide
2-(Benzyloxycarbonylamino)acetic acid→Dimethylamine hydrochloride→Benzyl [2-(dimethylamino)-2-oxoethyl]carbamate→N,N-Dimethylglycinamide→Carboxyethane→N-[2-(Dimethylamino)-2-oxoethyl]propanamide→1-Iodo-2-methoxybenzene→N-[2-(Dimethylamino)-2-oxoethyl]-3-(2-methoxyphenyl)propanamide→2-(5-Methoxy-2-oxo-3,4-dihydroquinolin-1(2H)-yl)-N,N-dimethylacetamide
2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride→2,5-Dioxo-3-oxazolidinecarboxylic acid 1,1-dimethylethyl ester→2-(Benzyloxycarbonylamino)acetic acid→2-((tert-Butoxycarbonyl)amino)acetic acid→2-Amino-1,1,1-trifluoroethane hydrochloride→2-Amino-1,1,1-trifluoroethane→Benzyl [2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]carbamate→[(2,2,2-Trifluoroethylcarbamoyl)methyl]carbamic acid tert-butyl ester→2-Chloranylethanoyl chloride→2-Chloro-N-(2,2,2-trifluoroethyl)acetamide→(N-Benzylaminomethyl)benzene→2-(Dibenzylamino)-N-(2,2,2-trifluoroethyl)acetamide
(S)-2-methylpyrrolidine-2-carboxylic acid→methyl (S)-2-methylpyrrolidine-2-carboxylate hydrochloride→2-(((benzyloxy)carbonyl)amino)acetic acid→methyl (S)-1-(((benzyloxy)carbonyl)glycyl)-2-methylpyrrolidine-2-carboxylate→(S)-1-(((benzyloxy)carbonyl)glycyl)-2-methylpyrrolidine-2-carboxylic acid→dibenzyl L-glutamate 4-methylbenzenesulfonate→dibenzyl ((S)-1-(((benzyloxy)carbonyl)glycyl)-2-methylpyrrolidine-2-carbonyl)-L-glutamate→Trofinetide
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 2-bromo-3-methyl-5-acetylthiophene Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | methyl 5-acetyl-3-methylthiophene-2-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 5-acetyl-3-methyl-2-Thiophenecarboxylic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | (S)-2-Methylproline Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 2-Methyl-L-proline Methyl ester hydrochloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。