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CAS 108-59-8
dimethyl malonate1,3-Dimethyl propanedioate
登记编号：BRIV-021、NINT-014、PRAL-020、RETAG-002、RISD-012、PEME-033、Urapidil-018、(IV)992511-1-a
应用背景（按来源药适应症）
癫痫部分性发作布瓦西坦癫痫布瓦西坦癫痫发作布瓦西坦系统性硬化相关肺间质疾病乙磺酸尼达尼布特发性肺纤维化乙磺酸尼达尼布非小细胞肺癌乙磺酸尼达尼布肺纤维化乙磺酸尼达尼布间质性肺疾病乙磺酸尼达尼布遗传性出血性毛细血管扩张乙磺酸尼达尼布外周T细胞淋巴瘤普拉曲沙T-细胞淋巴瘤普拉曲沙实体瘤普拉曲沙血液肿瘤普拉曲沙B-细胞淋巴瘤普拉曲沙皮肤T细胞淋巴瘤普拉曲沙二型糖尿病磷酸瑞格列汀糖尿病磷酸瑞格列汀肾功能不全磷酸瑞格列汀脊髓性肌萎缩利司扑兰非小细胞肺癌培美曲塞二钠间皮组织肿瘤培美曲塞二钠胸膜孤立性纤维瘤培美曲塞二钠膀胱癌培美曲塞二钠尿路上皮癌培美曲塞二钠实体瘤培美曲塞二钠高血压盐酸乌拉地尔慢性淋巴细胞白血病利沙托克拉急性早幼粒细胞白血病利沙托克拉骨髓增生异常综合征利沙托克拉急性髓细胞样白血病利沙托克拉弥漫性大B-细胞淋巴瘤利沙托克拉系统性红斑狼疮利沙托克拉
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 布瓦西坦Brivaracetam | Tier C · 观察 / 贸易 | 2028 |
| 乙磺酸尼达尼布Nintedanib Esylate | Tier B · 提前布局 | - |
| 普拉曲沙Pralatrexate | Tier C · 观察 / 贸易 | - |
| 磷酸瑞格列汀Retagliptin Phosphate | Tier C · 观察 / 贸易 | - |
| 利司扑兰Risdiplam | Tier B · 提前布局 | - |
| 培美曲塞二钠Pemetrexed Disodium Hydrate | Tier B · 提前布局 | - |
| 盐酸乌拉地尔Urapidil hydrochloride | Tier C · 观察 / 贸易 | - |
| 利沙托克拉Lisaftoclax | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(S)-2-aminobutanamide→(S)-2-((R)-2-oxo-4-propylpyrrolidin-1-yl)butanamide→pent-1-ene→(R)-pentane-1,2-diol→(4R)-4-propyl-1,3,2-dioxathiolane 2-oxide→(R)-4-propyl-1,3,2-dioxathiolane 2,2-dioxide→dimethyl malonate→(R)-dimethyl 2-propylcyclopropane-1,1-dicarboxylate→(R)-2-propylcyclopropane-1,1-dicarboxylic acid→(R)-6,6-dimethyl-1-propyl-5,7-dioxaspiro[2.5]octane-4,8-dione→(4R)-1-((S)-1-amino-1-oxobutan-2-yl)-2-oxo-4-propylpyrrolidine-3-carboxylic acid→1-((S)-1-amino-1-oxobutan-2-yl)-2-oxo-5-propylpyrrolidine-3-carboxylic acid→(4R)-methyl 1-((S)-1-amino-1-oxobutan-2-yl)-2-oxo-4-propylpyrrolidine-3-carboxylate→methyl 1-((S)-1-amino-1-oxobutan-2-yl)-2-oxo-5-propylpyrrolidine-3-carboxylate→(2S)-2-(2-oxo-5-propylpyrrolidin-1-yl)butanamide
methyl 2-oxo-1,3-dihydroindole-6-carboxylate →(trimethoxymethyl)benzene→N-(4-aminophenyl)-2-(4-methylpiperazin-1-yl)acetamide→1-methylpiperazine→4-chloro-3-nitrobenzoic acid→methyl 4-chloro-3-nitrobenzoate→dimethyl malonate→dimethyl 2-(4-(methoxycarbonyl)-2-nitrophenyl)malonate→2-chloroacetic anhydride→methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate→(Z)-methyl 1-(2-chloroacetyl)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate→(Z)-methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate→ethanesulfonic acid→N-methyl-4-nitroaniline→2-chloroacetyl chloride→2-chloro-N-methyl-N-(4-nitrophenyl)acetamide
methyl 4-formylbenzoate→methyl 4-(8-methoxy-6,8-dioxooct-1-yn-4-yl)benzoate→methyl (E)-4-(3-oxobut-1-en-1-yl)benzoate→dimethyl malonate→sodium 2,4'-bis(methoxycarbonyl)-5-oxo-1,2,5,6-tetrahydro-[1,1'-biphenyl]-3-olate→5'-hydroxy-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylic acid→methyl 5'-methoxy-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylate→methyl 5'-chloro-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylate→sodium (Z)-4-methoxy-4-oxobut-2-en-2-olate→methyl 5'-(2-methoxy-2-oxoethyl)-3'-oxo-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-4-carboxylate→4-nitrobenzenesulfonohydrazide
2-(2,4,5-trifluorophenyl)acetic acid→dimethyl malonate→methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate→(S)-2-amino-2-phenylethanol→(S,E)-methyl 3-((2-hydroxy-1-phenylethyl)amino)-4-(2,4,5-trifluorophenyl)but-2-enoate→(S)-3-phenyl-5-(2,4,5-trifluorobenzyl)-3,4-dihydro-1,4-oxazepin-7(2H)-one→(3S,5R)-3-phenyl-5-(2,4,5-trifluorobenzyl)-1,4-oxazepan-7-one→methyl 3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxylate→methyl 7-((R)-3-(((S)-2-hydroxy-1-phenylethyl)amino)-4-(2,4,5-trifluorophenyl)butanoyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxylate→methyl 2-amino-2-(pyrazin-2-yl)acetate hydrochloride→2,2,2-trifluoroacetic anhydride→methyl 2-(pyrazin-2-yl)-2-(2,2,2-trifluoroacetamido)acetate→methyl 3-(trifluoromethyl)imidazo[1,5-a]pyrazine-1-carboxylate
3,6-dichloro-4-methylpyridazine→6-chloro-5-methylpyridazin-3-amine→6-chloro-4-methylpyridazin-3-amine→1-bromo-2,2-dimethoxypropane→6-chloro-2,8-dimethylimidazo[1,2-b]pyridazine→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→2,8-dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine→2-chloro-7-fluoro-4H-pyrido[1,2-a]pyrimidin-4-one→2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-7-fluoro-4H-pyrido[1,2-a]pyrimidin-4-one→4,7-diazaspiro[2.5]octane hydrogen chloride→5-fluoropyridin-2-amine→dimethyl malonate→7-fluoro-2-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | Brivaracetam Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | (+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | Trimethyl orthobenzoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin -1-yl)acetamide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | Methyl 2-oxoindole-6-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | (3E)-2,3-Dihydro-3-(methoxyphenylmethylene) -2-oxo-1H-indole-6- carboxylic acid methyl ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 7-fluoro-2-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 4-Boc-4,7-diazaspiro[2.5]octane Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 2,8-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。