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CAS 109-01-3
1-methylpiperazineN-Methylpiperazine1-Methylpiperazine
登记编号：ERTU-039、NINT-010、Rifampicin-028、Conteltinib-008、(XII)955428-1-a、FOSNE-006、NMS-1286937-002
应用背景（按来源药适应症）
二型糖尿病艾托格列净二尖瓣闭锁不全艾托格列净左心室功能不全艾托格列净心脏衰竭艾托格列净动脉粥样硬化艾托格列净胰岛素抵抗艾托格列净系统性硬化相关肺间质疾病乙磺酸尼达尼布特发性肺纤维化乙磺酸尼达尼布非小细胞肺癌乙磺酸尼达尼布肺纤维化乙磺酸尼达尼布间质性肺疾病乙磺酸尼达尼布遗传性出血性毛细血管扩张乙磺酸尼达尼布结核分枝杆菌感染盐酸乙胺丁醇/利福平/异烟肼结核分枝杆菌感染利福平麻风分枝杆菌感染利福平肺结核利福平脑膜炎球菌性脑膜炎利福平新型冠状病毒感染利福平呼吸道病毒感染利福平非小细胞肺癌康特替尼实体瘤康特替尼胰腺癌康特替尼外周T细胞淋巴瘤戈利昔替尼EB病毒感染戈利昔替尼病毒感染戈利昔替尼组织细胞增生戈利昔替尼噬血细胞性淋巴组织细胞增多症戈利昔替尼间质性肺疾病戈利昔替尼化疗导致的恶心和呕吐福奈妥匹坦胰腺癌Onvansertib肾细胞癌Onvansertib乳腺癌Onvansertib三阴性乳腺癌Onvansertib炎性乳腺癌Onvansertib转移性乳腺癌Onvansertib
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 艾托格列净Ertugliflozin | Tier C · 观察 / 贸易 | - |
| 乙磺酸尼达尼布Nintedanib Esylate | Tier B · 提前布局 | - |
| 盐酸乙胺丁醇/利福平/异烟肼Ethambutol Hydrochloride/Rifampicin/Isoniazid | Tier C · 观察 / 贸易 | - |
| 右旋糖酐/氯化钙/氯化钾/氯化钠/乳酸钠Dextran/Calcium Chloride/Potassium Chloride/Sodium Chloride/Sodium lactate | Tier C · 观察 / 贸易 | - |
| 利福平Rifampicin | Tier C · 观察 / 贸易 | - |
| 康特替尼Conteltinib | Tier C · 观察 / 贸易 | - |
| 戈利昔替尼Golidocitinib | Tier C · 观察 / 贸易 | - |
| 福奈妥匹坦Fosnetupitant | Tier C · 观察 / 贸易 | - |
| Onvansertib | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol→(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one→1-methylpiperazine→(2R,3S,4R,5R)-2,3,4,6-tetrakis(benzyloxy)-5-hydroxy-1-(4-methylpiperazin-1-yl)hexan-1-one→(2R,3S,4S)-2,3,4,6-tetrakis(benzyloxy)-1-(4-methylpiperazin-1-yl)hexane-1,5-dione→iodomethyl pivalate→(3S,4S,5R)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)-2-hydroxy-6-(4-methylpiperazin-1-yl)-6-oxohexyl pivalate→(2R,3S,4S)-2,3,4,6-tetrakis(benzyloxy)-5-hydroxy-5-(hydroxymethyl)-1-(4-methylpiperazin-1-yl)hexan-1-one→(2R,3S,4S)-2,3,4-tris(benzyloxy)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one oxalate→(2R,3S,4S)-2,3,4-tris(benzyloxy)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one→2-((benzyloxy)(4-ethoxyphenyl)methyl)-4-bromo-1-chlorobenzene→(2R,3S,4S)-2,3,4-tris(benzyloxy)-1-(3-((benzyloxy)(4-ethoxyphenyl)methyl)-4-chlorophenyl)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)butan-1-one→(2S,3S,4R)-2,3,4-tris(benzyloxy)-1-((benzyloxy)methyl)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6,8-dioxabicyclo[3.2.1]octane→(1R,2S,3S,4R,5S)-1-(acetoxymethyl)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triyl triacetate
methyl 3-nitrobenzoate→methyl 2-chloroacetate→methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate→methyl 2-oxo-1,3-dihydroindole-6-carboxylate →methyl 1-acetyl-2-oxoindoline-6-carboxylate→(trimethoxymethyl)benzene→(Z)-methyl 1-acetyl-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate→N-(4-aminophenyl)-2-(4-methylpiperazin-1-yl)acetamide→2-bromo-N-methyl-N-(4-nitrophenyl)acetamide→1-methylpiperazine→N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
methyl 2-oxo-1,3-dihydroindole-6-carboxylate →(trimethoxymethyl)benzene→N-(4-aminophenyl)-2-(4-methylpiperazin-1-yl)acetamide→1-methylpiperazine→4-chloro-3-nitrobenzoic acid→methyl 4-chloro-3-nitrobenzoate→dimethyl malonate→dimethyl 2-(4-(methoxycarbonyl)-2-nitrophenyl)malonate→2-chloroacetic anhydride→methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate→(Z)-methyl 1-(2-chloroacetyl)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate→(Z)-methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate→ethanesulfonic acid→N-methyl-4-nitroaniline→2-chloroacetyl chloride→2-chloro-N-methyl-N-(4-nitrophenyl)acetamide
(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-Trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl acetate→N,N-Dihydroxymethyl-t-butylamine→2-Methylpropan-2-amine→(10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-3-tert-Butyl-6,7,19,21-tetrahydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate→(10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-6,7,19,21-Tetrahydroxy-15-methoxy-3,8,10,16,18,20,22,26-octamethyl-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate→(10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-6,7,19,21-Tetrahydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-3-[2-(morpholin-4-yl)ethyl]-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate→(10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-3-(1-Ethylpiperidin-3-yl)-6,7,19,21-tetrahydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate→4-Methylpiperazin-1-amine→N-Methylpiperazine
6-aminopyrimidine-2,4(1H,3H)-dione→2-chloroacetaldehyde→7H-pyrrolo[2,3-d]pyrimidine-2,4-diol→6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diol→2,4-dichloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine→2,4-dichloro-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine→tert-butyl 4-oxopiperidine-1-carboxylate→1-methylpiperazine→tert-butyl 4-(4-methylpiperazin-1-yl)piperidine-1-carboxylate→1-methyl-4-(piperidin-4-yl)piperazine→4-fluoro-2-methoxy-1-nitrobenzene→1-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine→2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline→2-methoxyethan-1-ol→4-chloro-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-amine→2-amino-N-isopropylbenzenesulfonamide→N-isopropyl-2-((2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)benzenesulfonamide
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | 2-((benzyloxy)(4-ethoxyphenyl)methyl)-4-bromo-1-chlorobenzene Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | (2R, 3S.4S)-2, 3, 4-tris(benzyloxy)-4-((R)-4-((benzyloxy)meth yl)-2, 2-dimeth yl-1, 3- dioxolan-4-yl)-1-(4-methylDiDerazin-1-yl)butan-1-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | Trimethyl orthobenzoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin -1-yl)acetamide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | Methyl 2-oxoindole-6-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | (3E)-2,3-Dihydro-3-(methoxyphenylmethylene) -2-oxo-1H-indole-6- carboxylic acid methyl ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。