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CAS 79099-07-3
tert-butyl 4-oxopiperidine-1-carboxylatetert-Butyl 4-oxopiperidine-1-carboxylate
登记编号：EDOX-020、Conteltinib-007、Vazegepant-001、Dalpiciclib Isethionate-022、(XV)965082-1-b、TNP-2092-005
应用背景（按来源药适应症）
肺栓塞甲苯磺酸艾多沙班静脉血栓栓塞甲苯磺酸艾多沙班中风甲苯磺酸艾多沙班栓塞甲苯磺酸艾多沙班静脉血栓形成甲苯磺酸艾多沙班缺血性卒中甲苯磺酸艾多沙班非小细胞肺癌康特替尼实体瘤康特替尼胰腺癌康特替尼偏头痛扎维吉泮无先兆偏头痛扎维吉泮有先兆的偏头痛扎维吉泮丛集性头痛扎维吉泮哮喘扎维吉泮新型冠状病毒感染扎维吉泮乳腺癌羟乙磺酸达尔西利转移性乳腺癌羟乙磺酸达尔西利前列腺癌羟乙磺酸达尔西利三阴性乳腺癌羟乙磺酸达尔西利脑膜瘤羟乙磺酸达尔西利肝功能衰退羟乙磺酸达尔西利边缘带B细胞淋巴瘤奥布替尼套细胞淋巴瘤奥布替尼慢性淋巴细胞白血病奥布替尼特发性血小板减少性紫癜奥布替尼系统性红斑狼疮奥布替尼多发性硬化奥布替尼假体相关感染Rifaquizinone糖尿病足溃疡Rifaquizinone感染性皮肤病Rifaquizinone皮肤和皮肤结构感染Rifaquizinone细菌性皮肤疾病Rifaquizinone幽门螺杆菌感染Rifaquizinone
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 甲苯磺酸艾多沙班Edoxaban Tosilate Hydrate | Tier B · 提前布局 | 2028 |
| 右旋糖酐/氯化钙/氯化钾/氯化钠/乳酸钠Dextran/Calcium Chloride/Potassium Chloride/Sodium Chloride/Sodium lactate | Tier C · 观察 / 贸易 | - |
| 康特替尼Conteltinib | Tier C · 观察 / 贸易 | - |
| 扎维吉泮Zavegepant | Tier C · 观察 / 贸易 | - |
| 羟乙磺酸达尔西利Dalpiciclib Isethionate | Tier C · 观察 / 贸易 | - |
| 奥布替尼Orelabrutinib | Tier C · 观察 / 贸易 | - |
| Rifaquizinone | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate→tert-butyl 4-oxopiperidine-1-carboxylate→tert-butyl 2-amino-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate→tert-butyl 2-bromo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate→2-bromo-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine→2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
6-aminopyrimidine-2,4(1H,3H)-dione→2-chloroacetaldehyde→7H-pyrrolo[2,3-d]pyrimidine-2,4-diol→6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diol→2,4-dichloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine→2,4-dichloro-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine→tert-butyl 4-oxopiperidine-1-carboxylate→1-methylpiperazine→tert-butyl 4-(4-methylpiperazin-1-yl)piperidine-1-carboxylate→1-methyl-4-(piperidin-4-yl)piperazine→4-fluoro-2-methoxy-1-nitrobenzene→1-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine→2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline→2-methoxyethan-1-ol→4-chloro-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-amine→2-amino-N-isopropylbenzenesulfonamide→N-isopropyl-2-((2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)benzenesulfonamide
6-aminopyrimidine-2,4(1H,3H)-dione→2-chloroacetaldehyde→7H-pyrrolo[2,3-d]pyrimidine-2,4-diol→6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diol→2,4-dichloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine→2,4-dichloro-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine→tert-butyl 4-oxopiperidine-1-carboxylate→1-methylpiperazine→tert-butyl 4-(4-methylpiperazin-1-yl)piperidine-1-carboxylate→1-methyl-4-(piperidin-4-yl)piperazine→4-fluoro-2-methoxy-1-nitrobenzene→1-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine→2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline→2-methoxyethan-1-ol→4-chloro-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-amine→2-amino-N-isopropylbenzenesulfonamide→N-isopropyl-2-((2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)benzenesulfonamide
tert-butyl 4-oxopiperidine-1-carboxylate→methyl 2-(dimethoxyphosphoryl)acetate→tert-butyl 4-(2-methoxy-2-oxoethylidene)piperidine-1-carboxylate→tert-butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate→2-nitrobenzaldehyde→tert-butyl 4-(1-hydroxy-3-methoxy-1-(2-nitrophenyl)-3-oxopropan-2-yl)piperidine-1-carboxylate→tert-butyl 4-(4-hydroxy-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)piperidine-1-carboxylate→3-(piperidin-4-yl)quinolin-2(1H)-one hydrochloride→2,6-dimethylaniline→4-iodo-2,6-dimethylaniline hydrochloride→methyl ((benzyloxy)carbonyl)-L-serinate→methyl 2-(((benzyloxy)carbonyl)amino)acrylate→methyl (Z)-3-(4-amino-3,5-dimethylphenyl)-2-(((benzyloxy)carbonyl)amino)acrylate→methyl (R)-3-(4-amino-3,5-dimethylphenyl)-2-(((benzyloxy)carbonyl)amino)propanoate→methyl (R)-2-(((benzyloxy)carbonyl)amino)-3-(7-methyl-1H-indazol-5-yl)propanoate→methyl (R)-2-amino-3-(7-methyl-1H-indazol-5-yl)propanoate→methyl (R)-3-(7-methyl-1H-indazol-5-yl)-2-(4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamido)propanoate→(R)-3-(7-methyl-1H-indazol-5-yl)-2-(4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamido)propanoic acid→1-(1-methylpiperidin-4-yl)piperazine
tert-Butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate→(9H-Fluoren-9-yl)methyl (5-bromopyridin-2-yl)carbamate→tert-Butyl 4-oxopiperidine-1-carboxylate→tert-Butyl 4-[6-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)pyridin-3-yl]-4-hydroxypiperidine-1-carboxylate
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | (R)-METHYL 2-(((BENZYLOXY)CARBONYL)AMINO)-3-(7-METHYL-1H-INDAZOL-5-YL)PROPANOATE Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 3-(piperidin-4-yl)quinolin-2(1h)-one hydrochloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 3-(piperidin-4-yl)quinolin-2(1h)-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 1-(1-Methyl-4-piperidinyl)piperazine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | methyl (2R)-2-amino-3-(7-methyl-1H-indazol-5-yl)propanoate dihydrochloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 1H-Indazole-5-propanoic acid,α-amino-7-methyl-,methyl ester, (αR)- Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 1-(1-METHYLPIPERIDIN-4-YL)PIPERAZINE 3HCL Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。