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CAS 123-11-5
4-Methoxybenzaldehyde4-(Methyloxy)benzaldehyde4-methoxybenzaldehyde
登记编号：Tamsulosin Hydrochloride-021、(X)140605-22-a、GAND-026
应用背景（按来源药适应症）
勃起功能障碍他达拉非/坦洛新前列腺增生他达拉非/坦洛新膀胱癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)头颈癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)头颈部鳞状细胞癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)实体瘤多西他赛纳米胶束 (Samyang Biopharmaceuticals)下尿路症状琥珀酸索利那新/盐酸坦洛新前列腺增生琥珀酸索利那新/盐酸坦洛新膀胱过度活动症琥珀酸索利那新/盐酸坦洛新药物相关的副作用和不良反应琥珀酸索利那新/盐酸坦洛新膀胱颈梗阻琥珀酸索利那新/盐酸坦洛新前列腺增生度他雄胺/盐酸坦洛新前列腺增生盐酸坦洛新泌尿系统感染盐酸坦洛新尿潴留盐酸坦洛新腹股沟疝盐酸坦洛新排尿功能障碍盐酸坦洛新下尿路症状盐酸坦洛新非小细胞肺癌多西他赛（贝海生物）前列腺癌多西他赛（贝海生物）去势抵抗性前列腺肿瘤多西他赛（贝海生物）乳腺癌多西他赛（贝海生物）头颈癌多西他赛（贝海生物）头颈部鳞状细胞癌多西他赛（贝海生物）血液肿瘤Gandotinib骨髓纤维化Gandotinib骨髓增生性疾病Gandotinib原发性血小板增多症Gandotinib真性红细胞增多症Gandotinib
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 他达拉非/坦洛新Tadalafil/Tamsulosin | Tier C · 观察 / 贸易 | - |
| 多西他赛纳米胶束 (Samyang Biopharmaceuticals)Docetaxel polymeric micelle (Samyang Biopharmaceuticals) | Tier C · 观察 / 贸易 | - |
| 琥珀酸索利那新/盐酸坦洛新Solifenacin Succinate/Tamsulosin Hydrochloride | Tier C · 观察 / 贸易 | - |
| 度他雄胺/盐酸坦洛新Dutasteride/Tamsulosin Hydrochloride | Tier C · 观察 / 贸易 | - |
| 盐酸坦洛新Tamsulosin Hydrochloride | Tier C · 观察 / 贸易 | - |
| 多西他赛（贝海生物）Docetaxel （Beihai） | Tier C · 观察 / 贸易 | - |
| Gandotinib | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
5-(2(R)-Aminopropyl)-2-methoxybenzenesulfonamide→Benzaldehyde→4-Methoxybenzaldehyde→4-Formylphenol→(4-Fluorophenyl)methanone→2-methoxy-5-[(2R)-2-[(E)-(phenylmethylidene)amino]propyl]benzene-1-sulfonamide→2-Methoxy-5-[(2R)-2-[(E)-[(4-methoxyphenyl)methylidene]amino]propyl]benzene-1-sulfonamide→5-[(2R)-2-[(E)-[(4-Hydroxyphenyl)methylidene]amino]propyl]-2-methoxybenzene-1-sulfonamide→5-[(2R)-2-[(E)-[(4-Fluorophenyl)methylidene]amino]propyl]-2-methoxybenzene-1-sulfonamide→1-ethoxy-2-(2-iodoethoxy)benzene→(E)-[2-(2-ethoxyphenoxy)ethyl][(2R)-1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl](phenylmethylidene)azanium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-methoxyphenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-hydroxyphenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-fluorophenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide
4-Methoxybenzaldehyde→2-Acetamidoacetic acid→(4E)-4-(4-Methoxybenzylidene)-2-methyl-1,3-oxazol-5(4H)-one→(2E)-2-(Acetylamino)-3-(4-methoxyphenyl)prop-2-enoic acid→N-Acetyl-O-methyl-L-tyrosine→O-Methyl-L-tyrosine→Ethyl O-methyl-L-tyrosinate→Ethyl N-[(benzyloxy)carbonyl]-O-methyl-L-tyrosinate→Benzyl [(2S)-1-hydroxy-3-(4-methoxyphenyl)propan-2-yl]carbamate→(2S)-2-[[(Benzyloxy)carbonyl]amino]-3-(4-methoxyphenyl)propyl 4-methylbenzenesulfonate→Benzyl [(2S)-1-iodo-3-(4-methoxyphenyl)propan-2-yl]carbamate→Benzyl [(2R)-1-(4-methoxyphenyl)propan-2-yl]carbamate
Benzaldehyde→1-Hydroxyacetone→(3R,4S)-3-Hydroxy-4-[(4-methoxyphenyl)amino]-4-phenylbutan-2-one→(4S,5R)-5-Acetyl-3-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidin-2-one→(4S,5R)-5-Acetyl-4-phenyl-1,3-oxazolidin-2-one→(2R,3S)-3-Amino-2-hydroxy-3-phenylpropanoic acid→(2R,3S)-3-Phenylisoserine methyl ester→Bis(1,1-dimethylethyl) dicarbonoate→3(S)-(tert-Butoxycarbonylamino)-2(R)-hydroxy-3-phenylpropionic acid methyl ester→4-(Methyloxy)benzaldehyde→2-(4-Methoxyphenyl)-4(S)-phenyloxazolidine-3,5(R)-dicarboxylic acid 3-tert-butyl 5-methyl diester→(4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid→Benzoic acid (2alpha,5beta,7beta,9beta,10beta,13alpha)-4,10-diacetoxy-1,9,13-trihydroxy-7-[methyl(diphenyl)silyloxy]-5,20-epoxytax-11-en-2-yl ester→2-(4-Methoxyphenyl)-4(S)-phenyloxazolidine-3,5(R)-dicarboxylic acid 3-tert-butyl 5-[(2aR,4S,4aR,5S,6R,9S,11S,12S,12aR,12bS)-6,12b-diacetoxy-12-(benzoyloxy)-5,11-dihydroxy-4a,8,13,13-tetramethyl-4-[methyl(diphenyl)silyloxy]-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-9-yl] diester
5-(2(R)-Aminopropyl)-2-methoxybenzenesulfonamide→Benzaldehyde→4-Methoxybenzaldehyde→4-Formylphenol→(4-Fluorophenyl)methanone→2-methoxy-5-[(2R)-2-[(E)-(phenylmethylidene)amino]propyl]benzene-1-sulfonamide→2-Methoxy-5-[(2R)-2-[(E)-[(4-methoxyphenyl)methylidene]amino]propyl]benzene-1-sulfonamide→5-[(2R)-2-[(E)-[(4-Hydroxyphenyl)methylidene]amino]propyl]-2-methoxybenzene-1-sulfonamide→5-[(2R)-2-[(E)-[(4-Fluorophenyl)methylidene]amino]propyl]-2-methoxybenzene-1-sulfonamide→1-ethoxy-2-(2-iodoethoxy)benzene→(E)-[2-(2-ethoxyphenoxy)ethyl][(2R)-1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl](phenylmethylidene)azanium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-methoxyphenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-hydroxyphenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-fluorophenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide
4-Methoxybenzaldehyde→2-Acetamidoacetic acid→(4E)-4-(4-Methoxybenzylidene)-2-methyl-1,3-oxazol-5(4H)-one→(2E)-2-(Acetylamino)-3-(4-methoxyphenyl)prop-2-enoic acid→N-Acetyl-O-methyl-L-tyrosine→O-Methyl-L-tyrosine→Ethyl O-methyl-L-tyrosinate→Ethyl N-[(benzyloxy)carbonyl]-O-methyl-L-tyrosinate→Benzyl [(2S)-1-hydroxy-3-(4-methoxyphenyl)propan-2-yl]carbamate→(2S)-2-[[(Benzyloxy)carbonyl]amino]-3-(4-methoxyphenyl)propyl 4-methylbenzenesulfonate→Benzyl [(2S)-1-iodo-3-(4-methoxyphenyl)propan-2-yl]carbamate→Benzyl [(2R)-1-(4-methoxyphenyl)propan-2-yl]carbamate
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