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度他雄胺/盐酸坦洛新
Tier C · 观察 / 贸易Dutasteride/Tamsulosin Hydrochloride
韩美药品株式会社
原研
2010
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：SRD5A、ADRA1A
商品名：Jalyn
适应症（已批准）：前列腺增生
各地区研发/上市状态
美国
批准上市
2010-06-14
欧盟
批准上市
2010-06-14
中国
临床一期
2024-04-10
日本
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生产该 API 的工厂9
口径：平台供应网络（富通询价明细 + 产品主档）中登记生产该品种的工厂（在产口径），按报价活跃度排序；快照不含成本与客户信息。
已收录 9 家在产工厂名单，登录后可见（工厂信息不对未登录访客展示）。
登录查看工厂名单 →合成路线与中间体26 routes
原研路线 × 1优化路线（非专利）× 23工艺路线 × 2
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 5 · 总收率 /
DUTA-001302-97-6DUTA-002328-93-8DUTA-003164656-19-3DUTA-004164656-20-6DUTA-005164656-21-7DUTA-006164656-22-8DUTA-00721149-38-2API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| DUTA-001 | 302-97-6 | (8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylic acid |
| DUTA-002 | 328-93-8 | 2,5-bis(trifluoromethyl)aniline |
| DUTA-003 | 164656-19-3 | (8S,9S,10R,13S,14S,17S)-N-(2,5-bis(trifluoromethyl)phenyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxamide |
| DUTA-004 | 164656-20-6 | 3-((3S,3aS,5aS,6R,9aS,9bS)-3-((2,5-bis(trifluoromethyl)phenyl)carbamoyl)-3a,6-dimethyl-7-oxododecahydro-1H-cyclopenta[a]naphthalen-6-yl)propanoic acid |
| DUTA-005 | 164656-21-7 | (4aR,4bS,6aS,7S,9aS,9bS)-N-(2,5-bis(trifluoromethyl)phenyl)-4a,6a-dimethyl-2-oxo-2,3,4,4a,4b,5,6,6a,7,8,9,9a,9b,10-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide |
| DUTA-006 | 164656-22-8 | (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-bis(trifluoromethyl)phenyl)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide |
| DUTA-007 | 21149-38-2 | 2,2,2-trifluoro-N,N-bis(trimethylsilyl)acetamide |
优化Route 1步骤 9 · 总收率 50.8g(Tamsulosin (Free))
Tamsulosin Hydrochloride-001122-84-9Tamsulosin Hydrochloride-0023886-69-9Tamsulosin Hydrochloride-003—Tamsulosin Hydrochloride-004121565-95-5Tamsulosin Hydrochloride-005112101-75-4Tamsulosin Hydrochloride-006116091-64-6Tamsulosin Hydrochloride-007103181-55-1Tamsulosin Hydrochloride-008106133-20-4Tamsulosin Hydrochloride-0093259-03-8Tamsulosin Hydrochloride-01094-71-3Tamsulosin Hydrochloride-01196-49-1Tamsulosin Hydrochloride-0123250-73-5API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-001 | 122-84-9 | 1-(4-Methoxyphenyl)-2-propanone |
| Tamsulosin Hydrochloride-002 | 3886-69-9在售 | (R)-(-)-1-Phenylethylamine |
| Tamsulosin Hydrochloride-003 | - | (2R)-1-(4-Methoxyphenyl)-N-[(1R)-1-phenylethyl]propan-2-amine hydrochloride |
| Tamsulosin Hydrochloride-004 | 121565-95-5 | 2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide |
| Tamsulosin Hydrochloride-005 | 112101-75-4 | 5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide hydrochloride |
| Tamsulosin Hydrochloride-006 | 116091-64-6 | 2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide hydrochloride |
| Tamsulosin Hydrochloride-007 | 103181-55-1 | (2-Ethoxyphenoxy)acetaldehyde |
| Tamsulosin Hydrochloride-008 | 106133-20-4 | (-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide |
| Tamsulosin Hydrochloride-009 | 3259-03-8 | 1-(2-Bromoethoxy)-2-ethoxybenzene |
| Tamsulosin Hydrochloride-010 | 94-71-3 | 1-Hydroxy-2-ethoxybenzene |
| Tamsulosin Hydrochloride-011 | 96-49-1 | 1,3-Dioxolan-2-one |
| Tamsulosin Hydrochloride-012 | 3250-73-5 | 2-(2-Ethoxyphenoxy)ethanol |
优化Route 2步骤 5 · 总收率 1.2g(Tamsulosin (Free))
Tamsulosin Hydrochloride-01386225-70-9Tamsulosin Hydrochloride-014434312-10-4Tamsulosin Hydrochloride-015—Tamsulosin Hydrochloride-016—Tamsulosin Hydrochloride-017754930-54-6Tamsulosin Hydrochloride-018760126-31-6API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-013 | 86225-70-9 | 5-(2-bromopropanoyl)-2-methoxybenzenesulfonamide |
| Tamsulosin Hydrochloride-014 | 434312-10-4 | benzyl[2-(2-ethoxyphenoxy)ethyl]amine |
| Tamsulosin Hydrochloride-015 | - | 5-(2-{benzyl[2-(2-ethoxyphenoxy)ethyl]amino}propanoyl)-2-methoxybenzenesulfonamide |
| Tamsulosin Hydrochloride-016 | - | 5-(2-{benzyl[2-(2-ethoxyphenoxy)ethyl]amino}-1-hydroxypropyl)-2-methoxybenzene-1-sulfonamide |
| Tamsulosin Hydrochloride-017 | 754930-54-6 | 5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}-1-hydroxypropyl)-2-methoxybenzenesulfonamide |
| Tamsulosin Hydrochloride-018 | 760126-31-6 | 5-(1-chloro-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzene-1-sulfonamide |
优化Route 3步骤 4 · 总收率 18g(Tamsulosin Hydrochloride (API))
Tamsulosin Hydrochloride-019112101-81-2Tamsulosin Hydrochloride-020100-52-7Tamsulosin Hydrochloride-021123-11-5Tamsulosin Hydrochloride-022123-08-0Tamsulosin Hydrochloride-023459-57-4Tamsulosin Hydrochloride-024—Tamsulosin Hydrochloride-025—Tamsulosin Hydrochloride-026—Tamsulosin Hydrochloride-027—Tamsulosin Hydrochloride-028663950-33-2Tamsulosin Hydrochloride-029—Tamsulosin Hydrochloride-030—Tamsulosin Hydrochloride-031663950-41-2Tamsulosin Hydrochloride-032—Tamsulosin Hydrochloride-008106133-20-4API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-019 | 112101-81-2 | 5-(2(R)-Aminopropyl)-2-methoxybenzenesulfonamide |
| Tamsulosin Hydrochloride-020 | 100-52-7在售 | Benzaldehyde |
| Tamsulosin Hydrochloride-021 | 123-11-5 | 4-Methoxybenzaldehyde |
| Tamsulosin Hydrochloride-022 | 123-08-0在售 | 4-Formylphenol |
| Tamsulosin Hydrochloride-023 | 459-57-4 | (4-Fluorophenyl)methanone |
| Tamsulosin Hydrochloride-024 | - | 2-methoxy-5-[(2R)-2-[(E)-(phenylmethylidene)amino]propyl]benzene-1-sulfonamide |
| Tamsulosin Hydrochloride-025 | - | 2-Methoxy-5-[(2R)-2-[(E)-[(4-methoxyphenyl)methylidene]amino]propyl]benzene-1-sulfonamide |
| Tamsulosin Hydrochloride-026 | - | 5-[(2R)-2-[(E)-[(4-Hydroxyphenyl)methylidene]amino]propyl]-2-methoxybenzene-1-sulfonamide |
| Tamsulosin Hydrochloride-027 | - | 5-[(2R)-2-[(E)-[(4-Fluorophenyl)methylidene]amino]propyl]-2-methoxybenzene-1-sulfonamide |
| Tamsulosin Hydrochloride-028 | 663950-33-2 | 1-ethoxy-2-(2-iodoethoxy)benzene |
| Tamsulosin Hydrochloride-029 | - | (E)-[2-(2-ethoxyphenoxy)ethyl][(2R)-1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl](phenylmethylidene)azanium iodide |
| Tamsulosin Hydrochloride-030 | - | (2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-methoxyphenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide |
| Tamsulosin Hydrochloride-031 | 663950-41-2 | (2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-hydroxyphenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide |
| Tamsulosin Hydrochloride-032 | - | (2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-fluorophenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide |
| Tamsulosin Hydrochloride-008 | 106133-20-4 | (-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide |
优化Route 4步骤 2 · 总收率 20.4g(Tamsulosin (Free))
Tamsulosin Hydrochloride-0123250-73-5Tamsulosin Hydrochloride-033169506-15-4Tamsulosin Hydrochloride-019112101-81-2API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-012 | 3250-73-5 | 2-(2-Ethoxyphenoxy)ethanol |
| Tamsulosin Hydrochloride-033 | 169506-15-4 | 2-(2-Ethoxyphenoxy)ethyl mesylate |
| Tamsulosin Hydrochloride-019 | 112101-81-2 | 5-(2(R)-Aminopropyl)-2-methoxybenzenesulfonamide |
优化Route 6步骤 6 · 总收率 /
Tamsulosin Hydrochloride-001122-84-9Tamsulosin Hydrochloride-0023886-69-9Tamsulosin Hydrochloride-040140173-30-4Tamsulosin Hydrochloride-041890708-65-3Tamsulosin Hydrochloride-0093259-03-8Tamsulosin Hydrochloride-042890708-67-5Tamsulosin Hydrochloride-043890708-68-6API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-001 | 122-84-9 | 1-(4-Methoxyphenyl)-2-propanone |
| Tamsulosin Hydrochloride-002 | 3886-69-9在售 | (R)-(-)-1-Phenylethylamine |
| Tamsulosin Hydrochloride-040 | 140173-30-4 | 1-(4-Methoxyphenyl)-N-[1(R)-phenylethyl]propan-2(R)-amine |
| Tamsulosin Hydrochloride-041 | 890708-65-3 | 5-[(2R)-2-aminopropyl]-2-methoxybenzene-1-sulfonic acid |
| Tamsulosin Hydrochloride-009 | 3259-03-8 | 1-(2-Bromoethoxy)-2-ethoxybenzene |
| Tamsulosin Hydrochloride-042 | 890708-67-5 | 5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzene-1-sulfonic acid |
| Tamsulosin Hydrochloride-043 | 890708-68-6 | 5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzenesulfonyl chloride |
优化Route 7步骤 14 · 总收率 2.091g(Tamsulosin Hydrochloride (API))
Tamsulosin Hydrochloride-04460-18-4Tamsulosin Hydrochloride-045537-55-3Tamsulosin Hydrochloride-046840-97-1Tamsulosin Hydrochloride-04735061-31-5Tamsulosin Hydrochloride-048855594-70-6Tamsulosin Hydrochloride-04986073-42-9Tamsulosin Hydrochloride-05037629-51-9Tamsulosin Hydrochloride-051128224-95-3Tamsulosin Hydrochloride-05269390-34-7Tamsulosin Hydrochloride-053112101-74-3Tamsulosin Hydrochloride-019112101-81-2Tamsulosin Hydrochloride-054916889-79-7Tamsulosin Hydrochloride-008106133-20-4Tamsulosin Hydrochloride-01094-71-3Tamsulosin Hydrochloride-055107-07-3Tamsulosin Hydrochloride-0123250-73-5API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-044 | 60-18-4 | (-)-alpha-Amino-p-hydroxyhydrocinnamic acid |
| Tamsulosin Hydrochloride-045 | 537-55-3 | N-Acetyl-L-tyrosine |
| Tamsulosin Hydrochloride-046 | 840-97-1 | Ethyl N-acetyl-L-tyrosinate |
| Tamsulosin Hydrochloride-047 | 35061-31-5 | Ethyl N-acetyl-O-methyl-L-tyrosinate |
| Tamsulosin Hydrochloride-048 | 855594-70-6 | N-[(2S)-1-Hydroxy-3-(4-methoxyphenyl)propan-2-yl]acetamide |
| Tamsulosin Hydrochloride-049 | 86073-42-9 | N-[(2R)-1-(4-Methoxyphenyl)propan-2-yl]acetamide |
| Tamsulosin Hydrochloride-050 | 37629-51-9 | 1-Methoxy-4-[(1E)-2-nitroprop-1-en-1-yl]benzene |
| Tamsulosin Hydrochloride-051 | 128224-95-3 | N-Hydroxy-1-(4-methoxyphenyl)propan-2-imine |
| Tamsulosin Hydrochloride-052 | 69390-34-7 | N-[(1E)-1-(4-Methoxyphenyl)prop-1-en-2-yl]acetamide |
| Tamsulosin Hydrochloride-053 | 112101-74-3 | N-[(2R)-1-(4-Methoxy-3-sulfamoylphenyl)propan-2-yl]acetamide |
| Tamsulosin Hydrochloride-019 | 112101-81-2 | 5-(2(R)-Aminopropyl)-2-methoxybenzenesulfonamide |
| Tamsulosin Hydrochloride-054 | 916889-79-7 | 2-(2-Ethoxyphenoxy)ethyl 4-methylbenzenesulfonate |
| Tamsulosin Hydrochloride-008 | 106133-20-4 | (-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide |
| Tamsulosin Hydrochloride-010 | 94-71-3 | 1-Hydroxy-2-ethoxybenzene |
| Tamsulosin Hydrochloride-055 | 107-07-3 | 1-Chloro-2-hydroxyethane |
| Tamsulosin Hydrochloride-012 | 3250-73-5 | 2-(2-Ethoxyphenoxy)ethanol |
优化Route 8步骤 2 · 总收率 3.28g(Tamsulosin (Free))
Tamsulosin Hydrochloride-0562323018-39-7Tamsulosin Hydrochloride-057—Tamsulosin Hydrochloride-0093259-03-8API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-056 | 2323018-39-7 | 5-(2-aminopropyl)-2-ethoxybenzenesulfonamide |
| Tamsulosin Hydrochloride-057 | - | 5-[(2R)-2-aminopropyl]-2-ethoxybenzene-1-sulfonamide |
| Tamsulosin Hydrochloride-009 | 3259-03-8 | 1-(2-Bromoethoxy)-2-ethoxybenzene |
优化Route 9步骤 5 · 总收率 46.28gTamsulosin Hydrochloride (API)
Tamsulosin Hydrochloride-058116091-63-5Tamsulosin Hydrochloride-0023886-69-9Tamsulosin Hydrochloride-006116091-64-6Tamsulosin Hydrochloride-019112101-81-2Tamsulosin Hydrochloride-005112101-75-4Tamsulosin Hydrochloride-0093259-03-8Tamsulosin Hydrochloride-008106133-20-4Tamsulosin Hydrochloride-033169506-15-4API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-058 | 116091-63-5 | 2-Methoxy-5-(2-oxopropyl)benzene-1-sulfonamide |
| Tamsulosin Hydrochloride-002 | 3886-69-9在售 | (R)-(-)-1-Phenylethylamine |
| Tamsulosin Hydrochloride-006 | 116091-64-6 | 2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide hydrochloride |
| Tamsulosin Hydrochloride-019 | 112101-81-2 | 5-(2(R)-Aminopropyl)-2-methoxybenzenesulfonamide |
| Tamsulosin Hydrochloride-005 | 112101-75-4 | 5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide hydrochloride |
| Tamsulosin Hydrochloride-009 | 3259-03-8 | 1-(2-Bromoethoxy)-2-ethoxybenzene |
| Tamsulosin Hydrochloride-008 | 106133-20-4 | (-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide |
| Tamsulosin Hydrochloride-033 | 169506-15-4 | 2-(2-Ethoxyphenoxy)ethyl mesylate |
优化Route 10步骤 6 · 总收率 80g（Tamsulosin Hydrochloride (API)）
Tamsulosin Hydrochloride-05958993-79-6Tamsulosin Hydrochloride-06079-04-9Tamsulosin Hydrochloride-036896468-68-1Tamsulosin Hydrochloride-037896468-69-2Tamsulosin Hydrochloride-038855298-56-5Tamsulosin Hydrochloride-01094-71-3Tamsulosin Hydrochloride-039133261-17-3Tamsulosin Hydrochloride-008106133-20-4API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-059 | 58993-79-6 | (-)-2-(4-Methoxyphenyl)-1-methylethanamine |
| Tamsulosin Hydrochloride-060 | 79-04-9在售 | 2-Chloranylethanoyl chloride |
| Tamsulosin Hydrochloride-036 | 896468-68-1 | 2-chloro-N-[(2R)-1-(4-methoxyphenyl)propan-2-yl]acetamide |
| Tamsulosin Hydrochloride-037 | 896468-69-2 | 5-[(2R)-2-(2-chloroacetamido)propyl]-2-methoxybenzene-1-sulfonyl chloride |
| Tamsulosin Hydrochloride-038 | 855298-56-5 | 2-chloro-N-[(2R)-1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl]acetamide |
| Tamsulosin Hydrochloride-010 | 94-71-3 | 1-Hydroxy-2-ethoxybenzene |
| Tamsulosin Hydrochloride-039 | 133261-17-3 | 2-(2-ethoxyphenoxy)-N-[(2R)-1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl]acetamide |
| Tamsulosin Hydrochloride-008 | 106133-20-4 | (-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide |
优化Route 11步骤 3 · 总收率 20g(Tamsulosin Hydrochloride-065)
Tamsulosin Hydrochloride-01094-71-3Tamsulosin Hydrochloride-061107-06-2Tamsulosin Hydrochloride-06256842-04-7Tamsulosin Hydrochloride-0631074-82-4Tamsulosin Hydrochloride-064153334-07-7Tamsulosin Hydrochloride-0656781-17-5API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-010 | 94-71-3 | 1-Hydroxy-2-ethoxybenzene |
| Tamsulosin Hydrochloride-061 | 107-06-2 | 1,2-Dichloroethane |
| Tamsulosin Hydrochloride-062 | 56842-04-7 | 1-(2-Chloroethoxy)-2-ethoxybenzene |
| Tamsulosin Hydrochloride-063 | 1074-82-4 | 1,3-Dihydro-1,3-dioxoisoindole potassium salt |
| Tamsulosin Hydrochloride-064 | 153334-07-7 | 2-[2-(2-Ethoxyphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione |
| Tamsulosin Hydrochloride-065 | 6781-17-5 | 2-(2-Ethoxyphenoxy)ethylamine |
优化Route 12步骤 11 · 总收率 /
Tamsulosin Hydrochloride-021123-11-5Tamsulosin Hydrochloride-066543-24-8Tamsulosin Hydrochloride-067711015-29-1Tamsulosin Hydrochloride-068646035-04-3Tamsulosin Hydrochloride-06928047-05-4Tamsulosin Hydrochloride-0706230-11-1Tamsulosin Hydrochloride-07117193-43-0Tamsulosin Hydrochloride-072115424-04-9Tamsulosin Hydrochloride-073115424-05-0Tamsulosin Hydrochloride-074115424-06-1Tamsulosin Hydrochloride-075115424-07-2Tamsulosin Hydrochloride-076115424-09-4API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-021 | 123-11-5 | 4-Methoxybenzaldehyde |
| Tamsulosin Hydrochloride-066 | 543-24-8 | 2-Acetamidoacetic acid |
| Tamsulosin Hydrochloride-067 | 711015-29-1 | (4E)-4-(4-Methoxybenzylidene)-2-methyl-1,3-oxazol-5(4H)-one |
| Tamsulosin Hydrochloride-068 | 646035-04-3 | (2E)-2-(Acetylamino)-3-(4-methoxyphenyl)prop-2-enoic acid |
| Tamsulosin Hydrochloride-069 | 28047-05-4 | N-Acetyl-O-methyl-L-tyrosine |
| Tamsulosin Hydrochloride-070 | 6230-11-1 | O-Methyl-L-tyrosine |
| Tamsulosin Hydrochloride-071 | 17193-43-0 | Ethyl O-methyl-L-tyrosinate |
| Tamsulosin Hydrochloride-072 | 115424-04-9 | Ethyl N-[(benzyloxy)carbonyl]-O-methyl-L-tyrosinate |
| Tamsulosin Hydrochloride-073 | 115424-05-0 | Benzyl [(2S)-1-hydroxy-3-(4-methoxyphenyl)propan-2-yl]carbamate |
| Tamsulosin Hydrochloride-074 | 115424-06-1 | (2S)-2-[[(Benzyloxy)carbonyl]amino]-3-(4-methoxyphenyl)propyl 4-methylbenzenesulfonate |
| Tamsulosin Hydrochloride-075 | 115424-07-2 | Benzyl [(2S)-1-iodo-3-(4-methoxyphenyl)propan-2-yl]carbamate |
| Tamsulosin Hydrochloride-076 | 115424-09-4 | Benzyl [(2R)-1-(4-methoxyphenyl)propan-2-yl]carbamate |
优化Route 13步骤 5 · 总收率 /
Tamsulosin Hydrochloride-077181132-60-5Tamsulosin Hydrochloride-058116091-63-5Tamsulosin Hydrochloride-07891-00-9Tamsulosin Hydrochloride-079—Tamsulosin Hydrochloride-08018531-94-7Tamsulosin Hydrochloride-08165355-14-8Tamsulosin Hydrochloride-082—Tamsulosin Hydrochloride-08335794-11-7API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-077 | 181132-60-5 | (4-Methoxy-3-sulfamoylphenyl)acetic acid |
| Tamsulosin Hydrochloride-058 | 116091-63-5 | 2-Methoxy-5-(2-oxopropyl)benzene-1-sulfonamide |
| Tamsulosin Hydrochloride-078 | 91-00-9 | 1,1-Diphenylmethylamine |
| Tamsulosin Hydrochloride-079 | - | 5-[(2R)-2-[(Diphenylmethyl)amino]propyl]-2-methoxybenzene-1-sulfonamide |
| Tamsulosin Hydrochloride-080 | 18531-94-7 | (+)-2,2'-Dihydroxy-1,1'-dinaphthyl |
| Tamsulosin Hydrochloride-081 | 65355-14-8 | (aR)-5,5',6,6',7,7',8,8'-Octahydro[1,1'-binaphthalene]-2,2'-diol |
| Tamsulosin Hydrochloride-082 | - | (aR)-4-Chloro-8,9,10,11,12,13,14,15-octahydro-4H-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine |
| Tamsulosin Hydrochloride-083 | 35794-11-7 | 3,5-Dimethylpiperidine |
优化Route 14步骤 6 · 总收率 /
Tamsulosin Hydrochloride-08485276-46-6Tamsulosin Hydrochloride-0656781-17-5Tamsulosin Hydrochloride-085—Tamsulosin Hydrochloride-086873442-10-5Tamsulosin Hydrochloride-08715761-39-4Tamsulosin Hydrochloride-088541-41-3Tamsulosin Hydrochloride-0891392268-76-6Tamsulosin Hydrochloride-0905834-17-3Tamsulosin Hydrochloride-0911096141-21-7Tamsulosin Hydrochloride-0921096141-19-3API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-084 | 85276-46-6 | 5-Acetyl-2-methoxybenzene-1-sulfonamide |
| Tamsulosin Hydrochloride-065 | 6781-17-5 | 2-(2-Ethoxyphenoxy)ethylamine |
| Tamsulosin Hydrochloride-085 | - | - |
| Tamsulosin Hydrochloride-086 | 873442-10-5 | (2R)-Hydroxy(phenyl)acetic acid 5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzene-1-sulfonamide |
| Tamsulosin Hydrochloride-087 | 15761-39-4 | (S)-1-(tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid |
| Tamsulosin Hydrochloride-088 | 541-41-3 | Carbonochloridic acid ethyl ester |
| Tamsulosin Hydrochloride-089 | 1392268-76-6 | Ethoxycarbonyl 1-(tert-butoxycarbonyl)-L-prolinate |
| Tamsulosin Hydrochloride-090 | 5834-17-3 | 2-Methoxydibenzo[b,d]furan-3-amine |
| Tamsulosin Hydrochloride-091 | 1096141-21-7 | tert-Butyl (2S)-2-[(2-methoxydibenzo[b,d]furan-3-yl)carbamoyl]pyrrolidine-1-carboxylate |
| Tamsulosin Hydrochloride-092 | 1096141-19-3 | N-(2-Methoxydibenzo[b,d]furan-3-yl)-L-prolinamide |
优化Route 15步骤 6 · 总收率 /
Tamsulosin Hydrochloride-001122-84-9Tamsulosin Hydrochloride-0023886-69-9Tamsulosin Hydrochloride-0932077235-60-8Tamsulosin Hydrochloride-040140173-30-4Tamsulosin Hydrochloride-05958993-79-6Tamsulosin Hydrochloride-094146374-27-8Tamsulosin Hydrochloride-0952077235-62-0Tamsulosin Hydrochloride-096—API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-001 | 122-84-9 | 1-(4-Methoxyphenyl)-2-propanone |
| Tamsulosin Hydrochloride-002 | 3886-69-9在售 | (R)-(-)-1-Phenylethylamine |
| Tamsulosin Hydrochloride-093 | 2077235-60-8 | (2E)-1-(4-Methoxyphenyl)-N-[(1R)-1-phenylethyl]propan-2-imine |
| Tamsulosin Hydrochloride-040 | 140173-30-4 | 1-(4-Methoxyphenyl)-N-[1(R)-phenylethyl]propan-2(R)-amine |
| Tamsulosin Hydrochloride-059 | 58993-79-6 | (-)-2-(4-Methoxyphenyl)-1-methylethanamine |
| Tamsulosin Hydrochloride-094 | 146374-27-8 | (+/-)-tert-Butyl sulfinamide |
| Tamsulosin Hydrochloride-095 | 2077235-62-0 | (SR)-N-[(2E)-1-(4-Methoxyphenyl)propan-2-ylidene]-2-methylpropane-2-sulfinamide |
| Tamsulosin Hydrochloride-096 | - | (SR)-N-[(2R)-1-(4-Methoxyphenyl)propan-2-yl]-2-methylpropane-2-sulfinamide |
优化Route 16步骤 3 · 总收率 10.4g(Tamsulosin Hydrochloride (API))
Tamsulosin Hydrochloride-006116091-64-6Tamsulosin Hydrochloride-0093259-03-8Tamsulosin Hydrochloride-0971076263-86-9Tamsulosin Hydrochloride-008106133-20-4API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-006 | 116091-64-6 | 2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide hydrochloride |
| Tamsulosin Hydrochloride-009 | 3259-03-8 | 1-(2-Bromoethoxy)-2-ethoxybenzene |
| Tamsulosin Hydrochloride-097 | 1076263-86-9 | 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl][(1R)-1-phenylethyl]amino]propyl]-2-methoxybenzene-1-sulfonamide |
| Tamsulosin Hydrochloride-008 | 106133-20-4 | (-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide |
优化Route 17步骤 9 · 总收率 /
Tamsulosin Hydrochloride-098104-01-8Tamsulosin Hydrochloride-001122-84-9Tamsulosin Hydrochloride-0997790-94-5Tamsulosin Hydrochloride-10080223-79-6Tamsulosin Hydrochloride-10175-64-9Tamsulosin Hydrochloride-1022761700-43-8Tamsulosin Hydrochloride-0023886-69-9Tamsulosin Hydrochloride-1032761700-44-9Tamsulosin Hydrochloride-1042761700-42-7Tamsulosin Hydrochloride-1056781-16-4Tamsulosin Hydrochloride-01094-71-3Tamsulosin Hydrochloride-106107-14-2Tamsulosin Hydrochloride-1072761700-45-0Tamsulosin Hydrochloride-008106133-20-4API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-098 | 104-01-8 | (4-Methoxyphenyl)acetic acid |
| Tamsulosin Hydrochloride-001 | 122-84-9 | 1-(4-Methoxyphenyl)-2-propanone |
| Tamsulosin Hydrochloride-099 | 7790-94-5 | Chloridosulfuric acid |
| Tamsulosin Hydrochloride-100 | 80223-79-6 | 2-Methoxy-5-(2-oxopropyl)benzene-1-sulfonyl chloride |
| Tamsulosin Hydrochloride-101 | 75-64-9在售 | 1,1-Dimethylethylamine |
| Tamsulosin Hydrochloride-102 | 2761700-43-8 | N-tert-Butyl-2-methoxy-5-(2-oxopropyl)benzene-1-sulfonamide |
| Tamsulosin Hydrochloride-002 | 3886-69-9在售 | (R)-(-)-1-Phenylethylamine |
| Tamsulosin Hydrochloride-103 | 2761700-44-9 | N-tert-Butyl-2-methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzene-1-sulfonamide |
| Tamsulosin Hydrochloride-104 | 2761700-42-7 | 5-[(2R)-2-Aminopropyl]-N-tert-butyl-2-methoxybenzene-1-sulfonamide |
| Tamsulosin Hydrochloride-105 | 6781-16-4 | (2-Ethoxyphenoxy)acetonitrile |
| Tamsulosin Hydrochloride-010 | 94-71-3 | 1-Hydroxy-2-ethoxybenzene |
| Tamsulosin Hydrochloride-106 | 107-14-2在售 | 2-Chloroacetonitrile |
| Tamsulosin Hydrochloride-107 | 2761700-45-0 | N-tert-Butyl-5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzene-1-sulfonamide |
| Tamsulosin Hydrochloride-008 | 106133-20-4 | (-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide |
优化Route 18步骤 7 · 总收率 165g(Racemic Tamsulosinc (Free))
Tamsulosin Hydrochloride-01196-49-1Tamsulosin Hydrochloride-01094-71-3Tamsulosin Hydrochloride-0123250-73-5Tamsulosin Hydrochloride-033169506-15-4Tamsulosin Hydrochloride-108107-21-1Tamsulosin Hydrochloride-1094672-49-5Tamsulosin Hydrochloride-1102761700-47-2Tamsulosin Hydrochloride-1022761700-43-8Tamsulosin Hydrochloride-1112761700-48-3Tamsulosin Hydrochloride-11294666-07-6API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-011 | 96-49-1 | 1,3-Dioxolan-2-one |
| Tamsulosin Hydrochloride-010 | 94-71-3 | 1-Hydroxy-2-ethoxybenzene |
| Tamsulosin Hydrochloride-012 | 3250-73-5 | 2-(2-Ethoxyphenoxy)ethanol |
| Tamsulosin Hydrochloride-033 | 169506-15-4 | 2-(2-Ethoxyphenoxy)ethyl mesylate |
| Tamsulosin Hydrochloride-108 | 107-21-1在售 | 1,2-Dihydroxyethane |
| Tamsulosin Hydrochloride-109 | 4672-49-5 | 1,2-Dimethylsulfonyloxyethane |
| Tamsulosin Hydrochloride-110 | 2761700-47-2 | 5-(2-Aminopropyl)-N-tert-butyl-2-methoxybenzene-1-sulfonamide |
| Tamsulosin Hydrochloride-102 | 2761700-43-8 | N-tert-Butyl-2-methoxy-5-(2-oxopropyl)benzene-1-sulfonamide |
| Tamsulosin Hydrochloride-111 | 2761700-48-3 | (±)-N-tert-Butyl-5-(2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl)-2-methoxybenzene-1-sulfonamide |
| Tamsulosin Hydrochloride-112 | 94666-07-6 | (±)-5-(2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl)-2-methoxybenzene-1-sulfonamide |
优化Route 20步骤 3 · 总收率 18.5g(Tamsulosin Hydrochloride-059)
Tamsulosin Hydrochloride-119126395-29-7Tamsulosin Hydrochloride-1202575821-58-6Tamsulosin Hydrochloride-121167421-85-4Tamsulosin Hydrochloride-05958993-79-6API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-119 | 126395-29-7 | tert-Butyl [(2S)-1-hydroxy-3-(4-methoxyphenyl)propan-2-yl]carbamate |
| Tamsulosin Hydrochloride-120 | 2575821-58-6 | tert-Butyl (2S)-2-[(4-methoxyphenyl)methyl]aziridine-1-carboxylate |
| Tamsulosin Hydrochloride-121 | 167421-85-4 | tert-Butyl [(2R)-1-(4-methoxyphenyl)propan-2-yl]carbamate |
| Tamsulosin Hydrochloride-059 | 58993-79-6 | (-)-2-(4-Methoxyphenyl)-1-methylethanamine |
优化Route 21步骤 8 · 总收率 /
Tamsulosin Hydrochloride-098104-01-8Tamsulosin Hydrochloride-001122-84-9Tamsulosin Hydrochloride-07891-00-9Tamsulosin Hydrochloride-122—Tamsulosin Hydrochloride-05958993-79-6Tamsulosin Hydrochloride-04986073-42-9Tamsulosin Hydrochloride-08018531-94-7Tamsulosin Hydrochloride-08165355-14-8Tamsulosin Hydrochloride-082—Tamsulosin Hydrochloride-08335794-11-7Tamsulosin Hydrochloride-123591-22-0API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-098 | 104-01-8 | (4-Methoxyphenyl)acetic acid |
| Tamsulosin Hydrochloride-001 | 122-84-9 | 1-(4-Methoxyphenyl)-2-propanone |
| Tamsulosin Hydrochloride-078 | 91-00-9 | 1,1-Diphenylmethylamine |
| Tamsulosin Hydrochloride-122 | - | (2R)-N-(Diphenylmethyl)-1-(4-methoxyphenyl)propan-2-amine |
| Tamsulosin Hydrochloride-059 | 58993-79-6 | (-)-2-(4-Methoxyphenyl)-1-methylethanamine |
| Tamsulosin Hydrochloride-049 | 86073-42-9 | N-[(2R)-1-(4-Methoxyphenyl)propan-2-yl]acetamide |
| Tamsulosin Hydrochloride-080 | 18531-94-7 | (+)-2,2'-Dihydroxy-1,1'-dinaphthyl |
| Tamsulosin Hydrochloride-081 | 65355-14-8 | (aR)-5,5',6,6',7,7',8,8'-Octahydro[1,1'-binaphthalene]-2,2'-diol |
| Tamsulosin Hydrochloride-082 | - | (aR)-4-Chloro-8,9,10,11,12,13,14,15-octahydro-4H-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine |
| Tamsulosin Hydrochloride-083 | 35794-11-7 | 3,5-Dimethylpiperidine |
| Tamsulosin Hydrochloride-123 | 591-22-0 | 3,5-Dimethylpyridine |
优化Route 2步骤 8 · 总收率 /
DUTA-001302-97-6DUTA-00876763-14-9DUTA-009103335-54-2DUTA-010103335-55-3DUTA-01173671-92-8DUTA-012103335-41-7DUTA-013104239-97-6DUTA-0142127-03-9DUTA-015103335-49-5DUTA-002328-93-8API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| DUTA-001 | 302-97-6 | (8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylic acid |
| DUTA-008 | 76763-14-9 | (3S,3aS,5aS,6R,9aS,9bS)-6-(2-carboxyethyl)-3a,6-dimethyl-7-oxododecahydro-1H-cyclopenta[a]naphthalene-3-carboxylic acid |
| DUTA-009 | 103335-54-2 | (4aR,4bS,6aS,7S,9aS,9bS)-4a,6a-dimethyl-2-oxo-2,3,4,4a,4b,5,6,6a,7,8,9,9a,9b,10-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid |
| DUTA-010 | 103335-55-3 | (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid |
| DUTA-011 | 73671-92-8 | methyl (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylate |
| DUTA-012 | 103335-41-7 | methyl (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylate |
| DUTA-013 | 104239-97-6 | (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid |
| DUTA-014 | 2127-03-9 | 1,2-di(pyridin-2-yl)disulfane |
| DUTA-015 | 103335-49-5 | (4aR,4bS,6aS,7S,9aS,9bS,11aR)-S-pyridin-2-yl 4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carbothioate |
| DUTA-002 | 328-93-8 | 2,5-bis(trifluoromethyl)aniline |
优化Route 3步骤 3 · 总收率 22 g (Dutasteride)
DUTA-010103335-55-3DUTA-013104239-97-6DUTA-016104214-61-1DUTA-017328-92-7API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| DUTA-010 | 103335-55-3 | (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid |
| DUTA-013 | 104239-97-6 | (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid |
| DUTA-016 | 104214-61-1 | (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide |
| DUTA-017 | 328-92-7 | 2-iodo-1,4-bis(trifluoromethyl)benzene |
优化Route 4步骤 10 · 总收率 613 g (Dutasteride)
DUTA-01857-83-0DUTA-0193510-20-1DUTA-0201416955-18-4DUTA-02194755-24-5DUTA-02220283-95-8DUTA-02373711-89-4DUTA-010103335-55-3DUTA-0241416955-19-5DUTA-002328-93-8DUTA-006164656-22-8DUTA-0251416955-20-8API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| DUTA-018 | 57-83-0 | (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one |
| DUTA-019 | 3510-20-1 | 3-((3S,3aS,5aS,6R,9aS,9bS)-3-acetyl-3a,6-dimethyl-7-oxododecahydro-1H-cyclopenta[a]naphthalen-6-yl)propanoic acid |
| DUTA-020 | 1416955-18-4 | 3-((3S,3aS,5aS,6R,9aS,9bS)-3-acetyl-3a,6-dimethyl-7-oxododecahydro-1H-cyclopenta[a]naphthalen-6-yl)propanoic (ethyl carbonic) anhydride |
| DUTA-021 | 94755-24-5 | (4aR,4bS,6aS,7S,9aS,9bS)-7-acetyl-11a-hydroxy-4a,6a-dimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one |
| DUTA-022 | 20283-95-8 | (4aR,4bS,6aS,7S,9aS,9bS)-7-acetyl-4a,6a-dimethyl-1,3,4,4a,4b,5,6,6a,7,8,9,9a,9b,10-tetradecahydro-2H-indeno[5,4-f]quinolin-2-one |
| DUTA-023 | 73711-89-4 | (4aR,4bS,6aS,7S,9aS,9bS,11aR)-7-acetyl-4a,6a-dimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one |
| DUTA-010 | 103335-55-3 | (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid |
| DUTA-024 | 1416955-19-5 | (ethyl carbonic) (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic anhydride |
| DUTA-002 | 328-93-8 | 2,5-bis(trifluoromethyl)aniline |
| DUTA-006 | 164656-22-8 | (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-bis(trifluoromethyl)phenyl)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide |
| DUTA-025 | 1416955-20-8 | (3R,4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-bis(trifluoromethyl)phenyl)-3-iodo-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide |
优化Route 5步骤 8 · 总收率 3.8 g (Dutasteride)
DUTA-02663-05-8DUTA-0276857-88-1DUTA-02851478-09-2DUTA-0291344087-70-2DUTA-030—DUTA-0311344087-72-4DUTA-010103335-55-3DUTA-013104239-97-6DUTA-002328-93-8API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| DUTA-026 | 63-05-8 | (8R,9S,10R,13S,14S)-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3H-cyclopenta[a]phenanthrene-3,17(2H)-dione |
| DUTA-027 | 6857-88-1 | 3-((3aS,5aS,6R,9aR,9bS)-3a,6-dimethyl-3,7-dioxododecahydro-1H-cyclopenta[a]naphthalen-6-yl)propanoic acid |
| DUTA-028 | 51478-09-2 | (4aR,4bS,6aS,9aS,9bR)-4a,6a-dimethyl-3,4,4a,4b,5,6,6a,8,9,9a,9b,10-dodecahydro-1H-indeno[5,4-f]quinoline-2,7-dione |
| DUTA-029 | 1344087-70-2 | (4aR,4bS,6aS,7R,9aS,9bR)-7-hydroxy-4a,6a,7-trimethyl-1,3,4,4a,4b,5,6,6a,7,8,9,9a,9b,10-tetradecahydro-2H-indeno[5,4-f]quinolin-2-one |
| DUTA-030 | - | (4aR,4bS,6aS,9aS,9bS)-4a,6a,7-trimethyl-1,3,4,4a,4b,5,6,6a,9,9a,9b,10-dodecahydro-2H-indeno[5,4-f]quinolin-2-one |
| DUTA-031 | 1344087-72-4 | (4aR,4bS,6aR,7S,9aS,9bS,11aR)-4a,6a,7-trimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one |
| DUTA-010 | 103335-55-3 | (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid |
| DUTA-013 | 104239-97-6 | (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid |
| DUTA-002 | 328-93-8 | 2,5-bis(trifluoromethyl)aniline |
工艺Route 5步骤 5 · 总收率 1.84kg(Tamsulosin (Free))
Tamsulosin Hydrochloride-03464-13-1Tamsulosin Hydrochloride-035105-39-5Tamsulosin Hydrochloride-036896468-68-1Tamsulosin Hydrochloride-037896468-69-2Tamsulosin Hydrochloride-038855298-56-5Tamsulosin Hydrochloride-01094-71-3Tamsulosin Hydrochloride-039133261-17-3API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-034 | 64-13-1 | (+-)-1-(p-Methoxyphenyl)-2-aminopropane |
| Tamsulosin Hydrochloride-035 | 105-39-5 | Ethyl 2-chloroacetate |
| Tamsulosin Hydrochloride-036 | 896468-68-1 | 2-chloro-N-[(2R)-1-(4-methoxyphenyl)propan-2-yl]acetamide |
| Tamsulosin Hydrochloride-037 | 896468-69-2 | 5-[(2R)-2-(2-chloroacetamido)propyl]-2-methoxybenzene-1-sulfonyl chloride |
| Tamsulosin Hydrochloride-038 | 855298-56-5 | 2-chloro-N-[(2R)-1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl]acetamide |
| Tamsulosin Hydrochloride-010 | 94-71-3 | 1-Hydroxy-2-ethoxybenzene |
| Tamsulosin Hydrochloride-039 | 133261-17-3 | 2-(2-ethoxyphenoxy)-N-[(2R)-1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl]acetamide |
工艺Route 19步骤 4 · 总收率 25.51kg(Tamsulosin Hydrochloride (API))
Tamsulosin Hydrochloride-11339684-80-5Tamsulosin Hydrochloride-11471999-74-1Tamsulosin Hydrochloride-01094-71-3Tamsulosin Hydrochloride-115—Tamsulosin Hydrochloride-0656781-17-5Tamsulosin Hydrochloride-116—Tamsulosin Hydrochloride-117—Tamsulosin Hydrochloride-118—API · 度他雄胺/盐酸坦洛新
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tamsulosin Hydrochloride-113 | 39684-80-5 | 2-(Boc-Amino)ethyl bromide |
| Tamsulosin Hydrochloride-114 | 71999-74-1 | tert-Butyl (2-chloroethyl)carbamate |
| Tamsulosin Hydrochloride-010 | 94-71-3 | 1-Hydroxy-2-ethoxybenzene |
| Tamsulosin Hydrochloride-115 | - | N-Boc-2-(2-ethoxyphenoxy)ethanamine |
| Tamsulosin Hydrochloride-065 | 6781-17-5 | 2-(2-Ethoxyphenoxy)ethylamine |
| Tamsulosin Hydrochloride-116 | - | (2S)-1-(4-Methoxy-3-sulfamoylphenyl)propan-2-yl methanesulfonate |
| Tamsulosin Hydrochloride-117 | - | (2S)-1-(4-Methoxy-3-sulfamoylphenyl)propan-2-yl trifluoroacetate |
| Tamsulosin Hydrochloride-118 | - | 5-[(2S)-2-Hydroxypropyl]-2-methoxybenzene-1-sulfonamide |
常见问题（FAQ）
度他雄胺/盐酸坦洛新的适应症有哪些？
已批准的适应症包括：前列腺增生。
度他雄胺/盐酸坦洛新的专利什么时候到期？
度他雄胺/盐酸坦洛新的专利到期年暂无公开口径，本页会在数据管道核实后更新。
度他雄胺/盐酸坦洛新有几条合成路线？
本站收录 26 条合成路线，最短路线 2 步、总收率 20.4g(Tamsulosin (Free))。每条路线的中间体均带登记编号与 CAS 号。
度他雄胺/盐酸坦洛新的关键中间体在哪里可以采购？
度他雄胺/盐酸坦洛新的多条路线中间体已挂接 CAS 档案，其中 7 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取度他雄胺/盐酸坦洛新中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22