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CAS 1576-35-8
4-Methylbenzenesulfonhydrazide
登记编号：(IX)461018-22-a、(XL)101438-55-d、(II)101438-62-a、(XX)101438-71-b、Dalpiciclib Isethionate-002
应用背景（按来源药适应症）
华氏巨球蛋白血症伊布替尼慢性淋巴细胞白血病伊布替尼套细胞淋巴瘤伊布替尼移植物抗宿主病伊布替尼乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate胰腺癌紫杉醇非小细胞肺癌紫杉醇霍奇金病紫杉醇精原细胞瘤紫杉醇卵巢癌紫杉醇乳腺癌紫杉醇乳腺癌羟乙磺酸达尔西利转移性乳腺癌羟乙磺酸达尔西利前列腺癌羟乙磺酸达尔西利三阴性乳腺癌羟乙磺酸达尔西利脑膜瘤羟乙磺酸达尔西利肝功能衰退羟乙磺酸达尔西利
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 伊布替尼Ibrutinib | Tier A · 立即攻坚 | 2027 |
| Paclitaxel/Encequidar mesylate | Tier C · 观察 / 贸易 | - |
| 紫杉醇Paclitaxel | Tier B · 提前布局 | - |
| 羟乙磺酸达尔西利Dalpiciclib Isethionate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
4-Phenoxybenzaldehyde→1,1-Dicyanomethane→[(4-Phenoxyphenyl)methylidene]propanedinitrile→Hydrazine hydrate→4-Methylbenzenesulfonhydrazide→5-Amino-3-(4-phenoxyphenyl)-2,3-dihydro-1H-pyrazole-4-carbonitrile→3-(4-Phenoxyphenyl)-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole→4-Methyl-N'-[(4-phenoxyphenyl)methyl]benzene-1-sulfonohydrazide→Amide c1
1,3-Dihydroxy-2,2-dimethylpropane→2,2-Dimethylcyclohexane-1,3-dione→2,2,4-Trimethylcyclohex-3-en-1-one→2,4,6-Triisopropyl-N'-[(1Z)-2,2,4-trimethylcyclohex-3-en-1-ylidene]benzenesulfonohydrazide→2,4,6-Triisopropylbenzenesulfonohydrazide→3,3,7,7-Tetramethyl-1,5-dioxaspiro[5.5]undecan-8-one→3,3,7,7,9-Pentamethyl-1,5-dioxaspiro[5.5]undec-8-ene→3,5-Cyclohexanedione→4-Methyl-N'-[(8E)-3,3,7,7-tetramethyl-1,5-dioxaspiro[5.5]undec-8-ylidene]benzenesulfonohydrazide→4-Methylbenzenesulfonhydrazide→Iodomethane
Dihydroxyacetic acid→4-Methylbenzenesulfonhydrazide→(2E)-[2-(4-Methylbenzene-1-sulfonyl)hydrazinylidene]acetic acid→(2E)-[2-(4-Methylbenzene-1-sulfonyl)hydrazinylidene]acetyl chloride→Benzaldehyde→1-Hydroxy-2,5-pyrrolidinedione→2,5-Dioxopyrrolidin-1-yl 2-diazoacetate→1-Aminobutane→N-Butyl-2-diazoacetamide→(2R,3R)-N-Butyl-3-phenyloxirane-2-carboxamide→tert-Butyl butyl[(2R,3R)-3-phenyloxirane-2-carbonyl]carbamate→Ethyl (2R,3R)-3-phenyloxirane-2-carboxylate→Ethyl (2R,3S)-3-azido-2-hydroxy-3-phenylpropanoate→alpha-Chlorobenzaldehyde→(1S,2R)-1-Azido-3-ethoxy-3-oxo-1-phenylpropan-2-yl benzoate→Ethyl (2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoate
(1S,5S,10S,11S,12S,16S)-10-(Benzyloxy)-7,11,14,14,18,21,21-heptamethyl-2,4,13,15-tetraoxapentacyclo[15.3.1.0(1,5).0(6,11).0(12,16)]henicosa-6,17-dien-3-one→(3aS,5S,8R,9aS,10S,13bS)-5-Hydroxy-6,9a,13,14,14-pentamethyl-12-[2-(4-methylbenzene-1-sulfonyl)hydrazinylidene]-2,9-dioxo-10-[(triethylsilyl)oxy]-5,8,9,9a,10,11,12,13b-octahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-8-yl acetate→(3aS,5S,8R,9aS,10S,13bS)-6,9a,13,14,14-Pentamethyl-12-[2-(4-methylbenzene-1-sulfonyl)hydrazinylidene]-2,9-dioxo-10-[(triethylsilyl)oxy]-5-[(trimethylsilyl)oxy]-5,8,9,9a,10,11,12,13b-octahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-8-yl acetate→(3aS,8R,9aS,10S,13bS)-10-(Benzyloxy)-6,9a,13,14,14-pentamethyl-2,9-dioxo-5,8,9,9a,10,11,12,13b-octahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-8-yl acetate→(3aS,8R,9aS,10S,13bS)-6,9a,13,14,14-Pentamethyl-2,5,9,12-tetraoxo-10-[(triethylsilyl)oxy]-5,8,9,9a,10,11,12,13b-octahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-8-yl acetate→(3aS,8R,9aS,10S,13bS)-6,9a,13,14,14-Pentamethyl-2,9-dioxo-10-[(triethylsilyl)oxy]-5,8,9,9a,10,11,12,13b-octahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-8-yl acetate→(3aS,8S,9S,9aR,10S,13bS)-10-(Benzyloxy)-8,9-dihydroxy-6,9a,13,14,14-pentamethyl-5,8,9,9a,10,11,12,13b-octahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-2-one→(3aS,8S,9S,9aR,10S,13bS)-10-(Benzyloxy)-9-hydroxy-6,9a,13,14,14-pentamethyl-2-oxo-5,8,9,9a,10,11,12,13b-octahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-8-yl acetate→4-Methylbenzenesulfonhydrazide→Acetic acid acetic anhydride
1,3-Dihydroxy-2,2-dimethylpropane→2,2-Dimethylcyclohexane-1,3-dione→2,2,4-Trimethylcyclohex-3-en-1-one→2,4,6-Triisopropyl-N'-[(1Z)-2,2,4-trimethylcyclohex-3-en-1-ylidene]benzenesulfonohydrazide→2,4,6-Triisopropylbenzenesulfonohydrazide→3,3,7,7-Tetramethyl-1,5-dioxaspiro[5.5]undecan-8-one→3,3,7,7,9-Pentamethyl-1,5-dioxaspiro[5.5]undec-8-ene→3,5-Cyclohexanedione→4-Methyl-N'-[(8E)-3,3,7,7-tetramethyl-1,5-dioxaspiro[5.5]undec-8-ylidene]benzenesulfonohydrazide→4-Methylbenzenesulfonhydrazide→Iodomethane
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