羟乙磺酸达尔西利

Tier C · 观察 / 贸易

Dalpiciclib Isethionate

江苏恒瑞医药股份有限公司

原研

2021

首批上市

到期年（公开口径）

无销量数据

峰值销售

化学药

类型

靶点：CDK6、CDK4

商品名：艾瑞康

适应症（已批准）：乳腺癌、转移性乳腺癌

各地区研发/上市状态

美国

欧盟

中国

批准上市

2021-12-31

日本

合成路线与中间体4 routes

原研路线 × 0优化路线（非专利）× 3工艺路线 × 1

路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。

优化Route 2步骤 8 · 总收率 261g(Dalpiciclib Isethionate-014)

Dalpiciclib Isethionate-0091016636-76-2Dalpiciclib Isethionate-0101637781-16-8Dalpiciclib Isethionate-011111-34-2Dalpiciclib Isethionate-0121637781-17-9Dalpiciclib Isethionate-0131980822-15-8Dalpiciclib Isethionate-0141980822-14-7Dalpiciclib Isethionate-0151637781-10-2Dalpiciclib Isethionate-0161637781-11-3Dalpiciclib Isethionate-017—Dalpiciclib Isethionate-01853939-30-3Dalpiciclib Isethionate-019286961-14-6Dalpiciclib Isethionate-020—API · 羟乙磺酸达尔西利

编号	CAS 号	中间体名称
Dalpiciclib Isethionate-009	1016636-76-2 在售	6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one
Dalpiciclib Isethionate-010	1637781-16-8	tert-Butyl 4-[6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperidine-1-carboxylate
Dalpiciclib Isethionate-011	111-34-2 在售	1-(Vinyloxy)butane
Dalpiciclib Isethionate-012	1637781-17-9	tert-Butyl 4-(6-[[6-(1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino]pyridin-3-yl)piperidine-1-carboxylate
Dalpiciclib Isethionate-013	1980822-15-8	tert-Butyl 4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperidine-1-carboxylate
Dalpiciclib Isethionate-014	1980822-14-7	2-Hydroxyethane-1-sulfonic acid 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperidin-4-yl)pyridin-2-yl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one
Dalpiciclib Isethionate-015	1637781-10-2	2-Amino-6-bromo-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Dalpiciclib Isethionate-016	1637781-11-3	2-Amino-6-(1-butoxyethenyl)-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Dalpiciclib Isethionate-017	-	tert-Butyl 6-chloro-3',6'-dihydro[3,4'-bipyridine]-1'(2'H)-carboxylate
Dalpiciclib Isethionate-018	53939-30-3 在售	5-Bromo-2-chloropyridine
Dalpiciclib Isethionate-019	286961-14-6	tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1(2H)-carboxylate
Dalpiciclib Isethionate-020	-	tert-Butyl 6-[[6-(1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino]-3',6'-dihydro[3,4'-bipyridine]-1'(2'H)-carboxylate

优化Route 3步骤 2 · 总收率 19.4g(Dalpiciclib Isethionate-008)

Dalpiciclib Isethionate-0081198408-35-3Dalpiciclib Isethionate-021—Dalpiciclib Isethionate-02279099-07-3Dalpiciclib Isethionate-023—API · 羟乙磺酸达尔西利

编号	CAS 号	中间体名称
Dalpiciclib Isethionate-008	1198408-35-3	tert-Butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate
Dalpiciclib Isethionate-021	-	(9H-Fluoren-9-yl)methyl (5-bromopyridin-2-yl)carbamate
Dalpiciclib Isethionate-022	79099-07-3 在售	tert-Butyl 4-oxopiperidine-1-carboxylate
Dalpiciclib Isethionate-023	-	tert-Butyl 4-[6-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)pyridin-3-yl]-4-hydroxypiperidine-1-carboxylate

优化Route 4步骤 4 · 总收率 52g(Dalpiciclib Isethionate-008)

Dalpiciclib Isethionate-004228710-82-5Dalpiciclib Isethionate-0081198408-35-3Dalpiciclib Isethionate-024—Dalpiciclib Isethionate-025110-86-1Dalpiciclib Isethionate-026—Dalpiciclib Isethionate-027—API · 羟乙磺酸达尔西利

编号	CAS 号	中间体名称
Dalpiciclib Isethionate-004	228710-82-5	5-Bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine
Dalpiciclib Isethionate-008	1198408-35-3	tert-Butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate
Dalpiciclib Isethionate-024	-	Chlorido[6-(2,5-dimethyl-1H-pyrrol-1-yl)pyridin-3-yl]magnesium
Dalpiciclib Isethionate-025	110-86-1	Pyridine
Dalpiciclib Isethionate-026	-	tert-Butyl 6-(2,5-dimethyl-1H-pyrrol-1-yl)[3,4'-bipyridine]-1'(4'H)-carboxylate
Dalpiciclib Isethionate-027	-	tert-Butyl 4-[6-(2,5-dimethyl-1H-pyrrol-1-yl)pyridin-3-yl]piperidine-1-carboxylate

工艺Route 1步骤 8 · 总收率 707g(Dalpiciclib Isethionate (Free))

Dalpiciclib Isethionate-0013612-20-2Dalpiciclib Isethionate-0021576-35-8Dalpiciclib Isethionate-00341780-52-3Dalpiciclib Isethionate-004228710-82-5Dalpiciclib Isethionate-0052348367-87-1Dalpiciclib Isethionate-0062348367-88-2Dalpiciclib Isethionate-0071159822-13-5Dalpiciclib Isethionate-0081198408-35-3Dalpiciclib Isethionate-0091016636-76-2Dalpiciclib Isethionate-0101637781-16-8API · 羟乙磺酸达尔西利

编号	CAS 号	中间体名称
Dalpiciclib Isethionate-001	3612-20-2	1-Benzylpiperidin-4-one
Dalpiciclib Isethionate-002	1576-35-8	4-Methylbenzenesulfonhydrazide
Dalpiciclib Isethionate-003	41780-52-3	N'-(1-Benzylpiperidin-4-ylidene)-4-methylbenzene-1-sulfonohydrazide
Dalpiciclib Isethionate-004	228710-82-5	5-Bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine
Dalpiciclib Isethionate-005	2348367-87-1	1'-Benzyl-6-(2,5-dimethyl-1H-pyrrol-1-yl)-1',2',3',6'-tetrahydro-3,4'-bipyridine
Dalpiciclib Isethionate-006	2348367-88-2	1'-Benzyl-1',2',3',6'-tetrahydro[3,4'-bipyridin]-6-amine
Dalpiciclib Isethionate-007	1159822-13-5	5-(Piperidin-4-yl)pyridin-2-amine
Dalpiciclib Isethionate-008	1198408-35-3	tert-Butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate
Dalpiciclib Isethionate-009	1016636-76-2 在售	6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one
Dalpiciclib Isethionate-010	1637781-16-8	tert-Butyl 4-[6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperidine-1-carboxylate

常见问题（FAQ）

羟乙磺酸达尔西利的适应症有哪些？

已批准的适应症包括：乳腺癌、转移性乳腺癌。

羟乙磺酸达尔西利的专利什么时候到期？

羟乙磺酸达尔西利的专利到期年暂无公开口径，本页会在数据管道核实后更新。

羟乙磺酸达尔西利有几条合成路线？

本站收录 4 条合成路线，最短路线 2 步、总收率 19.4g(Dalpiciclib Isethionate-008)。每条路线的中间体均带登记编号与 CAS 号。

羟乙磺酸达尔西利的关键中间体在哪里可以采购？

羟乙磺酸达尔西利的多条路线中间体已挂接 CAS 档案，其中 4 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。

如何获取羟乙磺酸达尔西利中间体的报价？

在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。

数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22