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CAS 16153-81-4
4-(4-methylpiperazin-1-yl)aniline
登记编号：OLMU-007、PHA-848125-014
应用背景（按来源药适应症）
非小细胞肺癌奥莫替尼非小细胞肺癌Milciclib maleate胸腺瘤Milciclib maleate肝细胞癌Milciclib maleate实体瘤Milciclib maleate
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 奥莫替尼Olmutinib | Tier C · 观察 / 贸易 | - |
| Milciclib maleate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
Methyl 3-aminothiophene-2-carboxylate→Urea→Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione→2,4-dichlorothieno[3,2-d]pyrimidine→3-nitrophenol→2-chloro-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidine→4-(4-methylpiperazin-1-yl)aniline→N-(4-(4-methylpiperazin-1-yl)phenyl)-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidin-2-amine→4-(3-aminophenoxy)-N-(4-(4-methylpiperazin-1-yl)phenyl)thieno[3,2-d]pyrimidin-2-amine→Acryloyl chloride
2,4-dichlorothieno[3,2-d]pyrimidine→4-(4-methylpiperazin-1-yl)aniline→N-(3-hydroxyphenyl)acrylamide→N-(3-((2-chlorothieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide
(Z)-ethyl 6-((dimethylamino)methylene)-1,4,4-trimethyl-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate→guanidine hydrochloride→ethyl 8-amino-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate→isopentyl nitrite→ethyl 8-iodo-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate→8-iodo-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid→5,5-dimethylcyclohexane-1,3-dione→3-methoxy-5,5-dimethylcyclohex-2-enone→4,4-dimethyl-7-oxabicyclo[4.1.0]heptan-2-one→2-methoxy-5,5-dimethylcyclohex-2-enone→ethyl 1,4,4-trimethyl-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate→1,1-di-tert-butoxy-N,N-dimethylmethanamine→8-iodo-N,1,4,4-tetramethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide→4-(4-methylpiperazin-1-yl)aniline
本站可供应的对应中间体
目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。