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CAS 4530-20-5
2-((tert-Butoxycarbonyl)amino)acetic acid2-((tert-butoxycarbonyl)amino)acetic acid
登记编号：(XVIb)700647-1-b、(VIb)1062329-1-a、FIRT-003
应用背景（按来源药适应症）
蠕形螨性睑缘炎洛替拉纳螨虫感染洛替拉纳莱姆病洛替拉纳酒渣鼻洛替拉纳睑板腺功能障碍洛替拉纳结直肠癌Firtecan pegol乳腺癌Firtecan pegol实体瘤Firtecan pegol转移性乳腺癌Firtecan pegol淋巴瘤Firtecan pegol
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 洛替拉纳Lotilaner | Tier C · 观察 / 贸易 | - |
| Dazdotuftide | Tier C · 观察 / 贸易 | - |
| Firtecan pegol | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride→2,5-Dioxo-3-oxazolidinecarboxylic acid 1,1-dimethylethyl ester→2-(Benzyloxycarbonylamino)acetic acid→2-((tert-Butoxycarbonyl)amino)acetic acid→2-Amino-1,1,1-trifluoroethane hydrochloride→2-Amino-1,1,1-trifluoroethane→Benzyl [2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]carbamate→[(2,2,2-Trifluoroethylcarbamoyl)methyl]carbamic acid tert-butyl ester→2-Chloranylethanoyl chloride→2-Chloro-N-(2,2,2-trifluoroethyl)acetamide→(N-Benzylaminomethyl)benzene→2-(Dibenzylamino)-N-(2,2,2-trifluoroethyl)acetamide
4-Aminophenyl 2-(trimethylammonio)ethyl phosphate→4-Diazoniophenyl 2-(trimethylazaniumyl)ethyl phosphate chloride→(2S)-3-(4-Hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid→N-[[(9H-Fluoren-9-yl)methoxy]carbonyl]-3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]-L-tyrosine→N-(tert-Butoxycarbonyl)-3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]-L-tyrosine→Resin bound 3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]-L-tyrosine→2-(9H-Fluoren-9-ylmethoxycarbonylamino)acetic acid→2-((tert-Butoxycarbonyl)amino)acetic acid→Resin bound glycyl-3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]-L-tyrosine→(2S)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-5-[2-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]pentanoic acid→(2S)-2-{[(tert-Butoxy)carbonyl]amino}-5-{N'-[(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]carbamimidamido}pentanoic acid→Resin bound N5-[N-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidoyl]-L-ornithylglycyl-3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]-L-tyrosine
(S)-4,11-diethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione→(S)-9-((tert-butyldiphenylsilyl)oxy)-4,11-diethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione→2-((tert-butoxycarbonyl)amino)acetic acid→(S)-9-((tert-butyldiphenylsilyl)oxy)-4,11-diethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl (tert-butoxycarbonyl)glycinate→(S)-9-((tert-butyldiphenylsilyl)oxy)-4,11-diethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl glycinate hydrochloride→tert-butyl 2-bromoacetate→7,7'-(oxybis(methylene))bis(3,6,9,12-tetraoxatetradecanedioic acid)→tetrakis((S)-9-((tert-butyldiphenylsilyl)oxy)-4,11-diethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl) 10,10'-(oxybis(methylene))bis(4,17-dioxo-6,9,12,15-tetraoxa-3,18-diazaicosanedioate)→2,2',2'',2'''-((oxybis(propane-3,1,2-triyl))tetrakis(oxy))tetrakis(ethan-1-ol)→tetra-tert-butyl 7,7'-(oxybis(methylene))bis(3,6,9,12-tetraoxatetradecanedioate)
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 2-bromo-3-methyl-5-acetylthiophene Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | methyl 5-acetyl-3-methylthiophene-2-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 5-acetyl-3-methyl-2-Thiophenecarboxylic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。