← 返回专利悬崖列表
CAS 50-00-0
FormaldehydeFormalin
登记编号：(VIII)270899-2-a、(XXXI)638294-1-d、(XIV)101438-55-a、Rifampicin-014、(XIII)909096-1-a、(X)909096-2-a,(X)909096-2-b
应用背景（按来源药适应症）
重度抑郁症盐酸艾司氯胺酮自杀意念盐酸艾司氯胺酮抑郁症盐酸艾司氯胺酮麻醉盐酸艾司氯胺酮难治性抑郁症盐酸艾司氯胺酮疼痛盐酸艾司氯胺酮收缩性心力衰竭非奈利酮舒张期心力衰竭非奈利酮心脏衰竭非奈利酮慢性肾功能不全非奈利酮糖尿病肾病非奈利酮二型糖尿病非奈利酮乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate结核分枝杆菌感染盐酸乙胺丁醇/利福平/异烟肼胰腺癌紫杉醇非小细胞肺癌紫杉醇霍奇金病紫杉醇精原细胞瘤紫杉醇卵巢癌紫杉醇乳腺癌紫杉醇结核分枝杆菌感染利福平麻风分枝杆菌感染利福平肺结核利福平脑膜炎球菌性脑膜炎利福平新型冠状病毒感染利福平呼吸道病毒感染利福平非小细胞肺癌伊鲁阿克
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 盐酸艾司氯胺酮Esketamine Hydrochloride | Tier B · 提前布局 | 2029 |
| 非奈利酮Finerenone | Tier C · 观察 / 贸易 | 2030 |
| Paclitaxel/Encequidar mesylate | Tier C · 观察 / 贸易 | - |
| 盐酸乙胺丁醇/利福平/异烟肼Ethambutol Hydrochloride/Rifampicin/Isoniazid | Tier C · 观察 / 贸易 | - |
| 紫杉醇Paclitaxel | Tier B · 提前布局 | - |
| 利福平Rifampicin | Tier C · 观察 / 贸易 | - |
| 伊鲁阿克Iruplinalkib | Tier C · 观察 / 贸易 | - |
| 氢溴酸依他佐辛Eptazocine hydrobromide | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-Chloro-2-iodobenzene→4-Cyclohexanone→2-(2-Chlorophenyl)cyclohexanone→(E)-Di-tert-butyl azodiformate→Di-tert-butyl 1-[(1S)-1-(2-chlorophenyl)-2-oxocyclohexyl]hydrazine-1,2-dicarboxylate→(-)-2(S)-Amino-2-(2-chlorophenyl)cyclohexanone→(1S)-2'-Chloro-1-isocyanato-6-methoxy-1,2,3,4-tetrahydro-1,1'-biphenyl→Formaldehyde→(2S)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
(2R,3S,4R)-3,4-Diacetoxy-3,4-dihydro-2H-pyran-2-yl]methyl acetate→Methyl 4,6-di-O-acetyl-2,3-dideoxy-alpha-D-erythro-hex-2-enopyranoside→Methyl 4,6-di-O-acetyl-2,3-dideoxy-alpha-D-erythro-hexopyranoside→Methyl 2,3-dideoxy-alpha-D-erythro-hexopyranoside→(6S)-6-(Benzyloxy)cyclohex-2-en-1-one→(2S,3S,6S)-2-(Iodomethyl)-6-methoxytetrahydro-2H-pyran-3-ol→(2S,3S,6S)-3-(Benzyloxy)-2-(iodomethyl)-6-methoxytetrahydro-2H-pyran→(3S,6S)-3-(Benzyloxy)-6-methoxy-2-methylenetetrahydro-2H-pyran→(2S,5R)-2-(Benzyloxy)-5-hydroxycyclohexanone→lithium carbanide→(6S)-6-(Benzyloxy)-1-methylcyclohex-2-en-1-ol→(4S)-4-(Benzyloxy)-3-methylcyclohex-2-en-1-one→Chloro(ethynyl)magnesium→Formaldehyde→(2R,3S,4S)-4-(Benzyloxy)-2-(hydroxymethyl)-3-methyl-3-vinylcyclohexanone→(2R,3S,4S)-4-(Benzyloxy)-3-methyl-2-[(tetrahydro-2H-pyran-2-yloxy)methyl]-3-vinylcyclohexanone→(1S,2R,3S,4S)-4-(Benzyloxy)-3-methyl-2-[(tetrahydro-2H-pyran-2-yloxy)methyl]-3-vinylcyclohexanol→2-[[(1R,2S,3S,6S)-3-(Benzyloxy)-6-(methoxymethoxy)-2-methyl-2-vinylcyclohexyl]methoxy]tetrahydro-2H-pyran
(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-Trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl acetate→Acetic acid (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl ester→Formaldehyde→(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-Pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-8-[(pyrrolidin-1-yl)methyl]-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate→(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-Pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-8-[(piperidin-1-yl)methyl]-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate→(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-Pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[(morpholin-4-yl)methyl]-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate→1-[[(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-(Acetyloxy)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-8-yl]methyl]piperidine-4-carboxylic acid→(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-[(2,6-Dimethylpiperidin-1-yl)methyl]-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate→(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-Pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[(4-methylpiperazin-1-yl)methyl]-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate→(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-[(Diethylamino)methyl]-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate→(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-[(Dimethylamino)methyl]-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
(2R,3S,4R)-3,4-Diacetoxy-3,4-dihydro-2H-pyran-2-yl]methyl acetate→Methyl 4,6-di-O-acetyl-2,3-dideoxy-alpha-D-erythro-hex-2-enopyranoside→Methyl 4,6-di-O-acetyl-2,3-dideoxy-alpha-D-erythro-hexopyranoside→Methyl 2,3-dideoxy-alpha-D-erythro-hexopyranoside→(6S)-6-(Benzyloxy)cyclohex-2-en-1-one→(2S,3S,6S)-2-(Iodomethyl)-6-methoxytetrahydro-2H-pyran-3-ol→(2S,3S,6S)-3-(Benzyloxy)-2-(iodomethyl)-6-methoxytetrahydro-2H-pyran→(3S,6S)-3-(Benzyloxy)-6-methoxy-2-methylenetetrahydro-2H-pyran→(2S,5R)-2-(Benzyloxy)-5-hydroxycyclohexanone→lithium carbanide→(6S)-6-(Benzyloxy)-1-methylcyclohex-2-en-1-ol→(4S)-4-(Benzyloxy)-3-methylcyclohex-2-en-1-one→Chloro(ethynyl)magnesium→Formaldehyde→(2R,3S,4S)-4-(Benzyloxy)-2-(hydroxymethyl)-3-methyl-3-vinylcyclohexanone→(2R,3S,4S)-4-(Benzyloxy)-3-methyl-2-[(tetrahydro-2H-pyran-2-yloxy)methyl]-3-vinylcyclohexanone→(1S,2R,3S,4S)-4-(Benzyloxy)-3-methyl-2-[(tetrahydro-2H-pyran-2-yloxy)methyl]-3-vinylcyclohexanol→2-[[(1R,2S,3S,6S)-3-(Benzyloxy)-6-(methoxymethoxy)-2-methyl-2-vinylcyclohexyl]methoxy]tetrahydro-2H-pyran
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 4-Bromo-2-methoxybenzaldehyde Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 4-AMino-5-Methylpyridin-2-ol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 2-chloro-5-methylpyridin-4-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。