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CAS 67-56-1
Hydroxymethane
登记编号：(XXXVI)638294-1-d、Ioflupane (123I)-008、(XXVI)145089-2-c、(X)755707-1-a
应用背景（按来源药适应症）
收缩性心力衰竭非奈利酮舒张期心力衰竭非奈利酮心脏衰竭非奈利酮慢性肾功能不全非奈利酮糖尿病肾病非奈利酮二型糖尿病非奈利酮路易氏体型失智症Ioflupane (123I)诊断剂Ioflupane (123I)帕金森综合征Ioflupane (123I)阿尔茨海默病Ioflupane (123I)帕金森病Ioflupane (123I)痴呆Ioflupane (123I)阿尔茨海默病重酒石酸卡巴拉汀痴呆重酒石酸卡巴拉汀帕金森病重酒石酸卡巴拉汀抗胆碱能综合征重酒石酸卡巴拉汀神经行为学表现重酒石酸卡巴拉汀认知障碍重酒石酸卡巴拉汀库欣综合征68Ga-pentixafor醛固酮增多症68Ga-pentixafor结节病68Ga-pentixafor移植物抗宿主病68Ga-pentixafor神经内分泌瘤68Ga-pentixafor边缘带B细胞淋巴瘤68Ga-pentixafor
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 非奈利酮Finerenone | Tier C · 观察 / 贸易 | 2030 |
| Ioflupane (123I) | Tier C · 观察 / 贸易 | - |
| 重酒石酸卡巴拉汀Rivastigmine Tartrate | Tier B · 提前布局 | - |
| 68Ga-pentixafor | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
8-Methyl-8-azabicyclo[3.2.1]octan-3-one→Carbonicaciddimethyldiester→Hydroxymethane→Methyl8-methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate→1,4-Dibromobenzene→(±)-Methyl(1R*,2S*,3S*,5S*)-3-(4-bromophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate→(±)-Methyl(1R*,2S*,3S*,5S*)-3-(4-bromophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate→1-Bromo-3-fluoropropane→Methyl(1R,2S,3S,5S)-3-(4-bromophenyl)-8-(3-fluoropropyl)-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl(1R,2S,3S,5S)-8-(3-fluoropropyl)-3-[4-(trimethylstannyl)phenyl]-8-azabicyclo[3.2.1]octane-2-carboxylate
1(S)-(3-Methoxyphenyl)-N,N-dimethylethylamine→(+/-)-3-Methoxy-alpha-methylbenzyl alcohol→(S)-(-)-2-Methyl-2-propanesulfinamide→(SS)-N-[(1S)-1-(3-Methoxyphenyl)ethyl]-2-methylpropane-2-sulfinamide→(1S)-1-(3-Methoxyphenyl)ethanamine→1-Ethyl-3-iodobenzene→Benzamide→N-[(1S)-1-(3-Iodophenyl)ethyl]benzamide→Hydroxymethane→N-[(1S)-1-(3-Methoxyphenyl)ethyl]benzamide→1,1,1-Triphenylmethanamine
2-(9H-Fluoren-9-ylmethoxycarbonylamino)acetic acid→Resin bound [([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)acetyl]oxy→Resin bound glycine→Fmoc-2-Nal-OH→TCP resin bound [[2(S)-amino-3-(naphthalen-2-yl)propanoyl]amino]acetic acid→(2S)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-5-[2-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]pentanoic acid→TCP resin bound [[(2S)-2-([(2S)-2-amino-5-[N'-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]pentanoyl]amino)-3-(naphthalen-2-yl)propanoyl]amino]acetic acid→N5-(4-Nitrobenzene-1-sulfonyl)-N2-[[(prop-2-en-1-yl)oxy]carbonyl]-D-ornithine→TCP resin bound (5S,8S,11R)-5-[(naphthalen-2-yl)methyl]-11-[(4-nitrobenzene-1-sulfonyl)amino]-4,7,10,16-tetraoxo-8-[3-[N'-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]propyl]-17-oxa-3,6,9,15-tetraazaicos-19-en-1-oic acid→Hydroxymethane→(5S,8S,11R)-11-[Methyl(4-nitrobenzene-1-sulfonyl)amino]-5-[(naphthalen-2-yl)methyl]-4,7,10,16-tetraoxo-8-[3-[N'-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]propyl]-17-oxa-3,6,9,15-tetraazaicos-19-en-1-oic acid→TCP resin bound (3R,6S,9S)-3-(3-aminopropyl)-9-[(naphthalen-2-yl)methyl]-2-(4-nitrobenzene-1-sulfonyl)-4,7,10-trioxo-6-[3-[N'-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]propyl]-2,5,8,11-tetraazatridecan-13-oic acid
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 4-Bromo-2-methoxybenzaldehyde Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 4-AMino-5-Methylpyridin-2-ol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 2-chloro-5-methylpyridin-4-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。