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CAS 51594-55-9
(2R)-2-(Chloromethyl)oxirane(R)-2-(chloromethyl)oxirane(R)-(-)-2-(Chloromethyl)oxirane
登记编号：Atorvastatin-079、LEVO-004、Timolol Maleate-010、LINE-021
应用背景（按来源药适应症）
心脏和血管疾病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高血压阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高脂血症阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利心脏病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利重度抑郁症盐酸左米那普仑缺血性卒中盐酸左米那普仑抑郁盐酸左米那普仑高脂血症阿托伐他汀锶蛛网膜下腔出血阿托伐他汀锶高血压阿托伐他汀锶高眼压酒石酸溴莫尼定/马来酸噻吗洛尔青光眼酒石酸溴莫尼定/马来酸噻吗洛尔高眼压贝美前列素/马来酸噻吗洛尔开角型青光眼贝美前列素/马来酸噻吗洛尔青光眼贝美前列素/马来酸噻吗洛尔高眼压马来酸噻吗洛尔青光眼马来酸噻吗洛尔开角型青光眼马来酸噻吗洛尔创伤和损伤马来酸噻吗洛尔高血压马来酸噻吗洛尔偏头痛马来酸噻吗洛尔非复杂性皮肤和皮肤结构感染利奈唑胺肺炎利奈唑胺复杂皮肤和皮肤结构感染利奈唑胺菌血症利奈唑胺细菌感染利奈唑胺医疗保健相关性肺炎利奈唑胺
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C · 观察 / 贸易 | - |
| 盐酸左米那普仑Levomilnacipran Hydrochloride | Tier C · 观察 / 贸易 | - |
| 阿托伐他汀锶Atorvastatin strontium | Tier C · 观察 / 贸易 | - |
| 酒石酸溴莫尼定/马来酸噻吗洛尔Brimonidine Tartrate/Timolol Maleate | Tier C · 观察 / 贸易 | - |
| 贝美前列素/马来酸噻吗洛尔Bimatoprost/Timolol Maleate | Tier C · 观察 / 贸易 | - |
| 马来酸噻吗洛尔Timolol Maleate | Tier C · 观察 / 贸易 | - |
| 利奈唑胺Linezolid | Tier B · 提前布局 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(3R)-3-Hydroxyhex-5-enenitrile→Chlorido(ethenyl)magnesium→(2R)-1-Chloropent-4-en-2-ol→(3R)-3-[(Trimethylsilyl)oxy]hex-5-enenitrile→tert-Butyl (5R)-5-hydroxy-3-oxooct-7-enoate→tert-Butyl [(4R,6R)-6-[(2E)-2-(hydroxyimino)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate→tert-Butyl (3R,5R)-3,5-dihydroxyoct-7-enoate→tert-Butyl [(4R,6R)-6-allyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate→tert-Butyl [(4R,6S)-2,2-dimethyl-6-(2-oxoethyl)-1,3-dioxan-4-yl]acetate→Hydroxylamine hydrochloric acid→(4R)-2,2-Dimethyl-6beta-(2-hydroxyethyl)-1,3-dioxane-4beta-acetic acid tert-butyl ester→tert-Butyl [(4R,6R)-6-[2-[(methanesulfonyl)oxy]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate→tert-Butyl [(4R,6R)-6-(2-azidoethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate→(2R)-2-(Chloromethyl)oxirane→1-Methoxy-1-methylethyl methyl ether→1,1-Dimethylethyl monobromoacetate→(4R,6R)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester→1,1-Dimethylethyl acetate→Methyl (3R)-3-hydroxyhex-5-enoate
(R)-2-(chloromethyl)oxirane→2-phenylacetonitrile→(1S,2R)-2-(hydroxymethyl)-1-phenylcyclopropanecarbonitrile→(1S,2R)-2-(hydroxymethyl)-1-phenylcyclopropanecarboxylic acid→(1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one→(1S,2R)-N,N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropanecarboxamide→(1S,2R)-2-(chloromethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide→potassium 1,3-dioxoisoindolin-2-ide→(1S,2R)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide
(3R)-3-Hydroxyhex-5-enenitrile→Chlorido(ethenyl)magnesium→(2R)-1-Chloropent-4-en-2-ol→(3R)-3-[(Trimethylsilyl)oxy]hex-5-enenitrile→tert-Butyl (5R)-5-hydroxy-3-oxooct-7-enoate→tert-Butyl [(4R,6R)-6-[(2E)-2-(hydroxyimino)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate→tert-Butyl (3R,5R)-3,5-dihydroxyoct-7-enoate→tert-Butyl [(4R,6R)-6-allyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate→tert-Butyl [(4R,6S)-2,2-dimethyl-6-(2-oxoethyl)-1,3-dioxan-4-yl]acetate→Hydroxylamine hydrochloric acid→(4R)-2,2-Dimethyl-6beta-(2-hydroxyethyl)-1,3-dioxane-4beta-acetic acid tert-butyl ester→tert-Butyl [(4R,6R)-6-[2-[(methanesulfonyl)oxy]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate→tert-Butyl [(4R,6R)-6-(2-azidoethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate→(2R)-2-(Chloromethyl)oxirane→1-Methoxy-1-methylethyl methyl ether→1,1-Dimethylethyl monobromoacetate→(4R,6R)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester→1,1-Dimethylethyl acetate→Methyl (3R)-3-hydroxyhex-5-enoate
2-(Chloromethyl)oxirane→(R)-(-)-2-(Chloromethyl)oxirane→3-Chloropropane-1,2(S)-diol→4-(4-Morpholinyl)-1,2,5-thiadiazol-3-ol→(2R)-1-Chloro-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol→4-[4-[(2S)-Oxiran-2-ylmethoxy]-1,2,5-thiadiazol-3-yl]morpholine→Sodium 4-(morpholin-4-yl)-1,2,5-thiadiazol-3-olate→(2S)-3-[[4-(Morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propane-1,2-diol→2-Methylpropan-2-amine→(S)-1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol
2-(Chloromethyl)oxirane→(R)-(-)-2-(Chloromethyl)oxirane→3-Chloropropane-1,2(S)-diol→4-(4-Morpholinyl)-1,2,5-thiadiazol-3-ol→(2R)-1-Chloro-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol→4-[4-[(2S)-Oxiran-2-ylmethoxy]-1,2,5-thiadiazol-3-yl]morpholine→Sodium 4-(morpholin-4-yl)-1,2,5-thiadiazol-3-olate→(2S)-3-[[4-(Morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propane-1,2-diol→2-Methylpropan-2-amine→(S)-1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol
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