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CAS 5927-18-4
methyl 2-(dimethoxyphosphoryl)acetate
登记编号：Vazegepant-002、Tibremciclib-004、PRAD-002
应用背景（按来源药适应症）
偏头痛扎维吉泮无先兆偏头痛扎维吉泮有先兆的偏头痛扎维吉泮丛集性头痛扎维吉泮哮喘扎维吉泮新型冠状病毒感染扎维吉泮乳腺癌酒石酸泰瑞西利转移性乳腺癌酒石酸泰瑞西利实体瘤酒石酸泰瑞西利便秘PradigastatI型高脂蛋白血症Pradigastat高甘油三酯血症Pradigastat冠状动脉病变Pradigastat丙型肝炎Pradigastat非酒精性脂肪性肝炎Pradigastat
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 扎维吉泮Zavegepant | Tier C · 观察 / 贸易 | - |
| 酒石酸泰瑞西利Tibremciclib Tartrate | Tier C · 观察 / 贸易 | - |
| Pradigastat | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
tert-butyl 4-oxopiperidine-1-carboxylate→methyl 2-(dimethoxyphosphoryl)acetate→tert-butyl 4-(2-methoxy-2-oxoethylidene)piperidine-1-carboxylate→tert-butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate→2-nitrobenzaldehyde→tert-butyl 4-(1-hydroxy-3-methoxy-1-(2-nitrophenyl)-3-oxopropan-2-yl)piperidine-1-carboxylate→tert-butyl 4-(4-hydroxy-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)piperidine-1-carboxylate→3-(piperidin-4-yl)quinolin-2(1H)-one hydrochloride→2,6-dimethylaniline→4-iodo-2,6-dimethylaniline hydrochloride→methyl ((benzyloxy)carbonyl)-L-serinate→methyl 2-(((benzyloxy)carbonyl)amino)acrylate→methyl (Z)-3-(4-amino-3,5-dimethylphenyl)-2-(((benzyloxy)carbonyl)amino)acrylate→methyl (R)-3-(4-amino-3,5-dimethylphenyl)-2-(((benzyloxy)carbonyl)amino)propanoate→methyl (R)-2-(((benzyloxy)carbonyl)amino)-3-(7-methyl-1H-indazol-5-yl)propanoate→methyl (R)-2-amino-3-(7-methyl-1H-indazol-5-yl)propanoate→methyl (R)-3-(7-methyl-1H-indazol-5-yl)-2-(4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamido)propanoate→(R)-3-(7-methyl-1H-indazol-5-yl)-2-(4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamido)propanoic acid→1-(1-methylpiperidin-4-yl)piperazine
(R)-3-aminobutan-1-ol→benzyl (R)-(4-hydroxybutan-2-yl)carbamate→benzyl (R)-(4-oxobutan-2-yl)carbamate→methyl 2-(dimethoxyphosphoryl)acetate→methyl (R,E)-5-(((benzyloxy)carbonyl)amino)hex-2-enoate→(R)-6-methylpiperidin-2-one
4-(4-hydroxyphenyl)cyclohexan-1-one→methyl 2-(dimethoxyphosphoryl)acetate→methyl 2-(4-(4-hydroxyphenyl)cyclohexylidene)acetate→methyl 2-((1r,4r)-4-(4-hydroxyphenyl)cyclohexyl)acetate→methyl 2-((1r,4r)-4-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)cyclohexyl)acetate→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→methyl 2-((1r,4r)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclohexyl)acetate→2,5-dibromopyridine→methyl 2-((1r,4r)-4-(4-(5-bromopyridin-2-yl)phenyl)cyclohexyl)acetate→6-(trifluoromethyl)pyridin-3-amine→methyl 2-((1r,4r)-4-(4-(5-((6-(trifluoromethyl)pyridin-3-yl)amino)pyridin-2-yl)phenyl)cyclohexyl)acetate
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | (R)-METHYL 2-(((BENZYLOXY)CARBONYL)AMINO)-3-(7-METHYL-1H-INDAZOL-5-YL)PROPANOATE Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 3-(piperidin-4-yl)quinolin-2(1h)-one hydrochloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 3-(piperidin-4-yl)quinolin-2(1h)-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 1-(1-Methyl-4-piperidinyl)piperazine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | methyl (2R)-2-amino-3-(7-methyl-1H-indazol-5-yl)propanoate dihydrochloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 1H-Indazole-5-propanoic acid,α-amino-7-methyl-,methyl ester, (αR)- Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 1-(1-METHYLPIPERIDIN-4-YL)PIPERAZINE 3HCL Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。