← 返回专利悬崖列表
CAS 638-29-9
pentanoyl chloride
登记编号：IRBE-023、VALS-006、VALR-011
应用背景（按来源药适应症）
高血压Atorvastatin Calcium Hydrate/Irbesartan高脂血症Atorvastatin Calcium Hydrate/Irbesartan高血压苯磺酸左旋氨氯地平/缬沙坦原发性高血压苯磺酸左旋氨氯地平/缬沙坦原发性高血压缬沙坦/氨氯地平乳清酸盐原发性高血压缬沙坦/盐酸乐卡地平高血压厄贝沙坦/三氯噻嗪左心室功能不全缬沙坦高血压缬沙坦原发性高血压缬沙坦肺动脉高压缬沙坦右心室功能障碍缬沙坦心肌梗塞后综合征缬沙坦食道疾病厄贝沙坦高血压厄贝沙坦糖尿病肾病厄贝沙坦高胆固醇血症厄贝沙坦白蛋白尿厄贝沙坦二型糖尿病厄贝沙坦膀胱癌戊柔比星原位癌戊柔比星尿路上皮癌戊柔比星
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Atorvastatin Calcium Hydrate/Irbesartan | Tier C · 观察 / 贸易 | - |
| 苯磺酸左旋氨氯地平/缬沙坦Levamlodipine Besylate/Valsartan | Tier C · 观察 / 贸易 | - |
| 缬沙坦/氨氯地平乳清酸盐Valsartan/Amlodipine Orotate | Tier C · 观察 / 贸易 | - |
| 缬沙坦/盐酸乐卡地平Valsartan/Lercanidipine Hydrochloride | Tier C · 观察 / 贸易 | - |
| 厄贝沙坦/三氯噻嗪Irbesartan/Trichlormethiazide | Tier C · 观察 / 贸易 | - |
| 缬沙坦Valsartan | Tier B · 提前布局 | - |
| 厄贝沙坦Irbesartan | Tier B · 提前布局 | - |
| 戊柔比星Valrubicin | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile→1-aminocyclopentane-1-carboxamide→pentanoyl chloride→1-pentanamidocyclopentane-1-carboxamide→N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-1-pentanamidocyclopentane-1-carboxamide
4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile→1-pentanamidocyclopentane-1-carboxylic acid→pentanoyl chloride→cyclopentanone→1-aminocyclopentane-1-carbonitrile→1-aminocyclopentane-1-carboxylic acid hydrochloride→4'-(aminomethyl)-[1,1'-biphenyl]-2-carbonitrile
4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-formyl-[1,1'-biphenyl]-2-carbonitrile→methyl L-valinate hydrochloride→(S)-methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoate→pentanoyl chloride→(S)-methyl 2-(N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate
methyl L-valinate hydrochloride→pentanoyl chloride→1-bromo-4-(bromomethyl)benzene→(S)-methyl 2-((4-bromobenzyl)amino)-3-methylbutanoate→(S)-methyl 2-(N-(4-bromobenzyl)pentanamido)-3-methylbutanoate→(2-(1-trityl-1H-tetrazol-5-yl)phenyl)boronic acid→(S)-methyl 3-methyl-2-(N-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)butanoate
4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-formyl-[1,1'-biphenyl]-2-carbonitrile→methyl L-valinate hydrochloride→(S)-methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoate→pentanoyl chloride→(S)-methyl 2-(N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate
本站可供应的对应中间体
目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。