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缬沙坦/氨氯地平乳清酸盐
Tier C · 观察 / 贸易Valsartan/Amlodipine Orotate
Dong-A ST Co Ltd
原研
2013
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：AT1
商品名：Orosartan
适应症（已批准）：原发性高血压
各地区研发/上市状态
美国
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欧盟
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中国
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日本
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生产该 API 的工厂11
口径：平台供应网络（富通询价明细 + 产品主档）中登记生产该品种的工厂（在产口径），按报价活跃度排序；快照不含成本与客户信息。
已收录 11 家在产工厂名单，登录后可见（工厂信息不对未登录访客展示）。
登录查看工厂名单 →合成路线与中间体14 routes
原研路线 × 1优化路线（非专利）× 13工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 5 · 总收率 /
VALS-001114772-54-2VALS-002154709-19-0VALS-003135689-93-9VALS-0046306-52-1VALS-005137863-89-9VALS-006638-29-9VALS-007137863-90-2API · 缬沙坦/氨氯地平乳清酸盐
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| VALS-001 | 114772-54-2 | 4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile |
| VALS-002 | 154709-19-0 | 4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carbonitrile |
| VALS-003 | 135689-93-9 | 4'-formyl-[1,1'-biphenyl]-2-carbonitrile |
| VALS-004 | 6306-52-1 | methyl L-valinate hydrochloride |
| VALS-005 | 137863-89-9 | (S)-methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoate |
| VALS-006 | 638-29-9 | pentanoyl chloride |
| VALS-007 | 137863-90-2 | (S)-methyl 2-(N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate |
优化Route 2步骤 3 · 总收率 /
VALS-008151052-40-3VALS-00972-18-4VALS-010676129-91-2VALS-011676129-92-3API · 缬沙坦/氨氯地平乳清酸盐
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| VALS-008 | 151052-40-3 | 2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-carbaldehyde |
| VALS-009 | 72-18-4 | (S)-2-amino-3-methylbutanoic acid |
| VALS-010 | 676129-91-2 | (S,Z)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methylene)amino)-3-methylbutanoic acid |
| VALS-011 | 676129-92-3 | (S)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoic acid |
优化Route 3步骤 3 · 总收率 /
VALS-0046306-52-1VALS-006638-29-9VALS-012589-15-1VALS-013867022-53-5VALS-014918447-44-6VALS-015144873-97-2VALS-016781664-81-1API · 缬沙坦/氨氯地平乳清酸盐
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| VALS-004 | 6306-52-1 | methyl L-valinate hydrochloride |
| VALS-006 | 638-29-9 | pentanoyl chloride |
| VALS-012 | 589-15-1 | 1-bromo-4-(bromomethyl)benzene |
| VALS-013 | 867022-53-5 | (S)-methyl 2-((4-bromobenzyl)amino)-3-methylbutanoate |
| VALS-014 | 918447-44-6 | (S)-methyl 2-(N-(4-bromobenzyl)pentanamido)-3-methylbutanoate |
| VALS-015 | 144873-97-2 | (2-(1-trityl-1H-tetrazol-5-yl)phenyl)boronic acid |
| VALS-016 | 781664-81-1 | (S)-methyl 3-methyl-2-(N-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)butanoate |
优化Route 1步骤 3 · 总收率 /
(I)109067-1-a638-07-3(II)109067-1-a1517-05-1(III)109067-1-a88150-45-2(IV)109067-1-a14205-39-1(V)109067-1-a89-98-5(VI)109067-1-a88150-46-3API · 缬沙坦/氨氯地平乳清酸盐
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)109067-1-a | 638-07-3 | Ethyl 4-chloro-3-oxobutanoate |
| (II)109067-1-a | 1517-05-1 | 2-azidoethan-1-ol |
| (III)109067-1-a | 88150-45-2 | ethyl 4-(2-azidoethoxy)-3-oxobutanoate |
| (IV)109067-1-a | 14205-39-1 | 3-Amino-2-butenoic acid methyl ester |
| (V)109067-1-a | 89-98-5 | 2-Chlorobenzaldehyde |
| (VI)109067-1-a | 88150-46-3 | 3-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
优化Route 2步骤 4 · 总收率 /
(I)109067-2-a638-07-3(II)109067-2-a2222844-70-2(III)109067-2-a3891-07-4(IV)109067-2-a88150-75-8(V)109067-2-a—(VI)109067-2-a1170036-31-3(VII)109067-2-a103094-30-0,88150-62-3API · 缬沙坦/氨氯地平乳清酸盐
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)109067-2-a | 638-07-3 | Ethyl 4-chloro-3-oxobutanoate |
| (II)109067-2-a | 2222844-70-2 | Ethyl 4-[(4-methylbenzene-1-sulfonyl)oxy]-3-oxobutanoate |
| (III)109067-2-a | 3891-07-4 | N-(2-Hydroxyethyl)phthalimide |
| (IV)109067-2-a | 88150-75-8 | Ethyl 4-(2-phthalimidoethoxy)acetoacetate |
| (V)109067-2-a | - | Ethyl (2Z)-3-amino-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]but-2-enoate |
| (VI)109067-2-a | 1170036-31-3 | Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate |
| (VII)109067-2-a | 103094-30-0,88150-62-3 | 3-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
优化Route 3步骤 3 · 总收率 /
(I)109067-3-a638-07-3(II)109067-3-a1517-05-1(III)109067-3-a88150-45-2(IV)109067-3-a1170036-31-3(V)109067-3-a88150-46-3API · 缬沙坦/氨氯地平乳清酸盐
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)109067-3-a | 638-07-3 | 4-Chloro-3-oxobutyric acid ethyl ester |
| (II)109067-3-a | 1517-05-1 | 2-azidoethan-1-ol |
| (III)109067-3-a | 88150-45-2 | ethyl 4-(2-azidoethoxy)-3-oxobutanoate |
| (IV)109067-3-a | 1170036-31-3 | Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate |
| (V)109067-3-a | 88150-46-3 | 3-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
优化Route 4步骤 6 · 总收率 /
(I)109067-4-a6065-82-3(II)109067-4-a621-63-6(III)109067-4-a638-07-3(IV)109067-4-a225939-10-6(V)109067-4-a89-98-5(VI)109067-4-a—(VII)109067-4-a14205-39-1(VIII)109067-4-a194472-23-6(IX)109067-4-a—(X)109067-4-a—(XI)109067-4-a1170036-31-3API · 缬沙坦/氨氯地平乳清酸盐
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)109067-4-a | 6065-82-3 | Diethoxyacetic acid ethyl ester |
| (II)109067-4-a | 621-63-6 | 2,2-Diethoxyethanol |
| (III)109067-4-a | 638-07-3 | 4-Chloro-3-oxobutyric acid ethyl ester |
| (IV)109067-4-a | 225939-10-6 | ethyl 4-(2,2-diethoxyethoxy)-3-oxobutanoate |
| (V)109067-4-a | 89-98-5 | 2-Chlorobenzaldehyde |
| (VI)109067-4-a | - | ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-4-(2,2-dimethoxyethoxy)-3-oxobutanoate |
| (VII)109067-4-a | 14205-39-1 | Methyl 3-amino-2-butenoate |
| (VIII)109067-4-a | 194472-23-6 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,2-dimethoxyethoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (IX)109067-4-a | - | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (X)109067-4-a | - | ethyl (2E)-3-amino-4-(2,2-diethoxyethoxy)but-2-enoate |
| (XI)109067-4-a | 1170036-31-3 | Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate |
优化Route 5步骤 4 · 总收率 /
(I)109067-5-a141-43-5(II)109067-5-a33885-01-7(III)109067-5-a24070-16-4(IV)109067-5-a638-07-3(V)109067-5-a156366-26-6(VI)109067-5-a89-98-5(VII)109067-5-a14205-39-1(VIII)109067-5-a156366-27-7API · 缬沙坦/氨氯地平乳清酸盐
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)109067-5-a | 141-43-5在售 | 2-Aminoethanol |
| (II)109067-5-a | 33885-01-7 | (2-chloro-1,1-diphenylethyl)benzene |
| (III)109067-5-a | 24070-16-4 | 2-[(triphenylmethyl)amino]ethan-1-ol |
| (IV)109067-5-a | 638-07-3 | Ethyl 4-chloroacetoacetate |
| (V)109067-5-a | 156366-26-6 | ethyl 3-oxo-4-{2-[(triphenylmethyl)amino]ethoxy}butanoate |
| (VI)109067-5-a | 89-98-5 | 2-Chlorobenzaldehyde |
| (VII)109067-5-a | 14205-39-1 | 3-Amino-2-butenoic acid methyl ester |
| (VIII)109067-5-a | 156366-27-7 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-({2-[(triphenylmethyl)amino]ethoxy}methyl)-1,4-dihydropyridine-3,5-dicarboxylate |
优化Route 6步骤 8 · 总收率 /
(I)109067-6-a1517-05-1(II)109067-6-a79-11-8(III)109067-6-a79598-48-4(IV)109067-6-a2033-24-1(V)109067-6-a109-78-4(VI)109067-6-a103069-47-2(VII)109067-6-a89-98-5(VIII)109067-6-a14205-39-1(IX)109067-6-a134471-46-8(X)109067-6-a134471-71-9(XI)109067-6-a66051-01-2(XII)109067-6-a—(XIII)109067-6-a103094-34-4(XIV)109067-6-a125711-60-6(XV)109067-6-a103129-82-4API · 缬沙坦/氨氯地平乳清酸盐
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)109067-6-a | 1517-05-1 | 2-azidoethan-1-ol |
| (II)109067-6-a | 79-11-8 | 2-Chloroacetic acid |
| (III)109067-6-a | 79598-48-4 | 2-(2-azidoethoxy)acetic acid |
| (IV)109067-6-a | 2033-24-1 | 2,2-Dimethyl-1,3-dioxane-4,6-dione |
| (V)109067-6-a | 109-78-4在售 | 3-Hydroxypropionitrile |
| (VI)109067-6-a | 103069-47-2 | 2-cyanoethyl 4-(2-azidoethoxy)-3-oxobutanoate |
| (VII)109067-6-a | 89-98-5 | 2-Chlorobenzaldehyde |
| (VIII)109067-6-a | 14205-39-1 | 3-Amino-2-butenoic acid methyl ester |
| (IX)109067-6-a | 134471-46-8 | 3-(2-cyanoethyl) 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (X)109067-6-a | 134471-71-9 | 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine-3-carboxylic acid |
| (XI)109067-6-a | 66051-01-2 | (2S)-2-methoxy-2-phenylethan-1-ol |
| (XII)109067-6-a | - | 3-(2S)-2-methoxy-2-phenylethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (XIII)109067-6-a | 103094-34-4 | 3-[(2S)-2-Methoxy-2-phenylethyl] 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (XIV)109067-6-a | 125711-60-6 | 3-Ethyl 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (XV)109067-6-a | 103129-82-4 | 3-Ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
优化Route 7步骤 6 · 总收率 /
(I)109067-8-a—(II)109067-8-a,(II)109067-8-b638-07-3(III)109067-8-a194472-29-2(IV)109067-8-a,(IV)109067-8-b89-98-5(V)109067-8-a,(V)109067-8-b14205-39-1(VI)109067-8-a194472-10-1(VII)109067-8-a194472-12-3(VIII)109067-8-a,(VIII)109067-8-b194472-14-5(IX)109067-8-a,(IX)109067-8-b—API · 缬沙坦/氨氯地平乳清酸盐
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)109067-8-a | - | [5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methanol |
| (II)109067-8-a,(II)109067-8-b | 638-07-3 | 4-Chloro-3-oxobutyric acid ethyl ester |
| (III)109067-8-a | 194472-29-2 | ethyl 4-({5-[(4-ethoxy-2,4-dioxobutoxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methoxy)-3-oxobutanoate |
| (IV)109067-8-a,(IV)109067-8-b | 89-98-5 | 2-Chlorobenzaldehyde |
| (V)109067-8-a,(V)109067-8-b | 14205-39-1 | 3-Amino-2-butenoic acid methyl ester |
| (VI)109067-8-a | 194472-10-1 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-({[5-({[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (VII)109067-8-a | 194472-12-3 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(4-{[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}-2,3-dihydroxybutoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (VIII)109067-8-a,(VIII)109067-8-b | 194472-14-5 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[(2-oxoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate |
| (IX)109067-8-a,(IX)109067-8-b | - | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
优化Route 8步骤 4 · 总收率 /
(II)109067-8-a,(II)109067-8-b638-07-3(IV)109067-8-a,(IV)109067-8-b89-98-5(V)109067-8-a,(V)109067-8-b14205-39-1(VIII)109067-8-a,(VIII)109067-8-b194472-14-5(IX)109067-8-a,(IX)109067-8-b—(X)109067-8-b22323-82-6(XI)109067-8-b110464-45-4(XII)109067-8-b—(XIII)109067-8-b194472-30-5API · 缬沙坦/氨氯地平乳清酸盐
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (II)109067-8-a,(II)109067-8-b | 638-07-3 | 4-Chloro-3-oxobutyric acid ethyl ester |
| (IV)109067-8-a,(IV)109067-8-b | 89-98-5 | 2-Chlorobenzaldehyde |
| (V)109067-8-a,(V)109067-8-b | 14205-39-1 | 3-Amino-2-butenoic acid methyl ester |
| (VIII)109067-8-a,(VIII)109067-8-b | 194472-14-5 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[(2-oxoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate |
| (IX)109067-8-a,(IX)109067-8-b | - | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (X)109067-8-b | 22323-82-6 | [(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methanol |
| (XI)109067-8-b | 110464-45-4 | ethyl 4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]-3-oxobutanoate |
| (XII)109067-8-b | - | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (XIII)109067-8-b | 194472-30-5 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,3-dihydroxypropoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
优化Route 9步骤 5 · 总收率 /
(I)109067-9-a23326-27-4(II)109067-9-a100-46-9(III)109067-9-a24405-35-4(IV)109067-9-a—(V)109067-9-a39562-06-6(VI)109067-9-a1309115-67-0(VII)109067-9-a1517-05-1(VIII)109067-9-a—API · 缬沙坦/氨氯地平乳清酸盐
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)109067-9-a | 23326-27-4 | 2-Butynoic acid methyl ester |
| (II)109067-9-a | 100-46-9在售 | 1-Phenylmethylamine |
| (III)109067-9-a | 24405-35-4 | ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate |
| (IV)109067-9-a | - | 3-methyl 5-propyl 1-benzyl-4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (V)109067-9-a | 39562-06-6 | 3-ethyl 5-methyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (VI)109067-9-a | 1309115-67-0 | 3-ethyl 5-methyl 2-(bromomethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| (VII)109067-9-a | 1517-05-1 | 2-azidoethan-1-ol |
| (VIII)109067-9-a | - | 3-methyl 5-propyl 6-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
优化Route 10步骤 2 · 总收率 /
(I)158395-3-a2032-35-1(II)158395-3-a—(III)158395-3-a621-63-6API · 缬沙坦/氨氯地平乳清酸盐
常见问题（FAQ）
缬沙坦/氨氯地平乳清酸盐的适应症有哪些？
已批准的适应症包括：原发性高血压。
缬沙坦/氨氯地平乳清酸盐的专利什么时候到期？
缬沙坦/氨氯地平乳清酸盐的专利到期年暂无公开口径，本页会在数据管道核实后更新。
缬沙坦/氨氯地平乳清酸盐有几条合成路线？
本站收录 14 条合成路线，最短路线 1 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
缬沙坦/氨氯地平乳清酸盐的关键中间体在哪里可以采购？
缬沙坦/氨氯地平乳清酸盐的多条路线中间体已挂接 CAS 档案，其中 4 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取缬沙坦/氨氯地平乳清酸盐中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22