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缬沙坦/盐酸乐卡地平
Tier C · 观察 / 贸易Valsartan/Lercanidipine Hydrochloride
Lg Chemical Ltd
原研
2013
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：AT1、VDCCs
商品名：Levacalm
适应症（已批准）：原发性高血压
各地区研发/上市状态
美国
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欧盟
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中国
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日本
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生产该 API 的工厂11
口径：平台供应网络（富通询价明细 + 产品主档）中登记生产该品种的工厂（在产口径），按报价活跃度排序；快照不含成本与客户信息。
已收录 11 家在产工厂名单，登录后可见（工厂信息不对未登录访客展示）。
登录查看工厂名单 →合成路线与中间体17 routes
原研路线 × 1优化路线（非专利）× 16工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 5 · 总收率 /
VALS-001114772-54-2VALS-002154709-19-0VALS-003135689-93-9VALS-0046306-52-1VALS-005137863-89-9VALS-006638-29-9VALS-007137863-90-2API · 缬沙坦/盐酸乐卡地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| VALS-001 | 114772-54-2 | 4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile |
| VALS-002 | 154709-19-0 | 4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carbonitrile |
| VALS-003 | 135689-93-9 | 4'-formyl-[1,1'-biphenyl]-2-carbonitrile |
| VALS-004 | 6306-52-1 | methyl L-valinate hydrochloride |
| VALS-005 | 137863-89-9 | (S)-methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoate |
| VALS-006 | 638-29-9 | pentanoyl chloride |
| VALS-007 | 137863-90-2 | (S)-methyl 2-(N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate |
优化Route 2步骤 3 · 总收率 /
VALS-008151052-40-3VALS-00972-18-4VALS-010676129-91-2VALS-011676129-92-3API · 缬沙坦/盐酸乐卡地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| VALS-008 | 151052-40-3 | 2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-carbaldehyde |
| VALS-009 | 72-18-4 | (S)-2-amino-3-methylbutanoic acid |
| VALS-010 | 676129-91-2 | (S,Z)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methylene)amino)-3-methylbutanoic acid |
| VALS-011 | 676129-92-3 | (S)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoic acid |
优化Route 3步骤 3 · 总收率 /
VALS-0046306-52-1VALS-006638-29-9VALS-012589-15-1VALS-013867022-53-5VALS-014918447-44-6VALS-015144873-97-2VALS-016781664-81-1API · 缬沙坦/盐酸乐卡地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| VALS-004 | 6306-52-1 | methyl L-valinate hydrochloride |
| VALS-006 | 638-29-9 | pentanoyl chloride |
| VALS-012 | 589-15-1 | 1-bromo-4-(bromomethyl)benzene |
| VALS-013 | 867022-53-5 | (S)-methyl 2-((4-bromobenzyl)amino)-3-methylbutanoate |
| VALS-014 | 918447-44-6 | (S)-methyl 2-(N-(4-bromobenzyl)pentanamido)-3-methylbutanoate |
| VALS-015 | 144873-97-2 | (2-(1-trityl-1H-tetrazol-5-yl)phenyl)boronic acid |
| VALS-016 | 781664-81-1 | (S)-methyl 3-methyl-2-(N-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)butanoate |
优化Route 1步骤 9 · 总收率 /
Lercanidipine Hydrochloride-001674-82-8Lercanidipine Hydrochloride-002100442-33-9Lercanidipine Hydrochloride-003100427-51-8Lercanidipine Hydrochloride-00499-61-6Lercanidipine Hydrochloride-005100427-54-1Lercanidipine Hydrochloride-00614205-39-1Lercanidipine Hydrochloride-00774936-72-4API · 缬沙坦/盐酸乐卡地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Lercanidipine Hydrochloride-001 | 674-82-8在售 | 4-Methylene-2-oxetanone |
| Lercanidipine Hydrochloride-002 | 100442-33-9 | 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol |
| Lercanidipine Hydrochloride-003 | 100427-51-8 | 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl 3-oxobutanoate |
| Lercanidipine Hydrochloride-004 | 99-61-6 | (3-Nitrophenyl)methanone |
| Lercanidipine Hydrochloride-005 | 100427-54-1 | 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl (2Z)-2-[(3-nitrophenyl)methylidene]-3-oxobutanoate |
| Lercanidipine Hydrochloride-006 | 14205-39-1 | 3-Amino-2-butenoic acid methyl ester |
| Lercanidipine Hydrochloride-007 | 74936-72-4 | (+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid |
优化Route 2步骤 3 · 总收率 /
Lercanidipine Hydrochloride-008105-45-3Lercanidipine Hydrochloride-009558-42-9Lercanidipine Hydrochloride-010—Lercanidipine Hydrochloride-00499-61-6Lercanidipine Hydrochloride-011—Lercanidipine Hydrochloride-00614205-39-1Lercanidipine Hydrochloride-012890045-70-2Lercanidipine Hydrochloride-013890045-71-3Lercanidipine Hydrochloride-00774936-72-4Lercanidipine Hydrochloride-01488712-56-5Lercanidipine Hydrochloride-01538254-49-8Lercanidipine Hydrochloride-01628075-29-8API · 缬沙坦/盐酸乐卡地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Lercanidipine Hydrochloride-008 | 105-45-3在售 | 1-Methoxybutane-1,3-dione |
| Lercanidipine Hydrochloride-009 | 558-42-9 | 1-Chloro-2-methyl-2-propanol |
| Lercanidipine Hydrochloride-010 | - | 1-Chloro-2-methylpropan-2-yl 3-oxobutanoate |
| Lercanidipine Hydrochloride-004 | 99-61-6 | (3-Nitrophenyl)methanone |
| Lercanidipine Hydrochloride-011 | - | 1-Chloro-2-methylpropan-2-yl (2Z)-2-[(3-nitrophenyl)methylidene]-3-oxobutanoate |
| Lercanidipine Hydrochloride-006 | 14205-39-1 | 3-Amino-2-butenoic acid methyl ester |
| Lercanidipine Hydrochloride-012 | 890045-70-2 | 3-(1-Chloro-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| Lercanidipine Hydrochloride-013 | 890045-71-3 | 3-(1-Bromo-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| Lercanidipine Hydrochloride-007 | 74936-72-4 | (+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid |
| Lercanidipine Hydrochloride-014 | 88712-56-5 | 5-(Chlorocarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid methyl ester |
| Lercanidipine Hydrochloride-015 | 38254-49-8 | 1-Bromo-2-methylpropan-2-ol |
| Lercanidipine Hydrochloride-016 | 28075-29-8 | (3,3-Diphenylpropyl)(methyl)amine |
优化Route 3步骤 2 · 总收率 /
Lercanidipine Hydrochloride-01628075-29-8Lercanidipine Hydrochloride-017105-53-3Lercanidipine Hydrochloride-01891-01-0Lercanidipine Hydrochloride-019—Lercanidipine Hydrochloride-020—Lercanidipine Hydrochloride-02174-89-5Lercanidipine Hydrochloride-022348607-76-1API · 缬沙坦/盐酸乐卡地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Lercanidipine Hydrochloride-016 | 28075-29-8 | (3,3-Diphenylpropyl)(methyl)amine |
| Lercanidipine Hydrochloride-017 | 105-53-3在售 | 1,3-Diethyl propanedioate |
| Lercanidipine Hydrochloride-018 | 91-01-0 | 1,1-Diphenylmethanol |
| Lercanidipine Hydrochloride-019 | - | Diethyl (diphenylmethyl)propanedioate |
| Lercanidipine Hydrochloride-020 | - | Ethyl 3,3-diphenylpropanoate |
| Lercanidipine Hydrochloride-021 | 74-89-5 | Methylamine |
| Lercanidipine Hydrochloride-022 | 348607-76-1 | N-Methyl-3,3-diphenylpropanamide |
优化Route 4步骤 4 · 总收率 /
Lercanidipine Hydrochloride-01628075-29-8Lercanidipine Hydrochloride-009558-42-9Lercanidipine Hydrochloride-002100442-33-9Lercanidipine Hydrochloride-023936491-32-6Lercanidipine Hydrochloride-00774936-72-4API · 缬沙坦/盐酸乐卡地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Lercanidipine Hydrochloride-016 | 28075-29-8 | (3,3-Diphenylpropyl)(methyl)amine |
| Lercanidipine Hydrochloride-009 | 558-42-9 | 1-Chloro-2-methyl-2-propanol |
| Lercanidipine Hydrochloride-002 | 100442-33-9 | 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol |
| Lercanidipine Hydrochloride-023 | 936491-32-6 | (2-chloro-2-methylpropyl)(3,3-diphenylpropyl)methylamine |
| Lercanidipine Hydrochloride-007 | 74936-72-4 | (+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid |
优化Route 5步骤 4 · 总收率 /
Lercanidipine Hydrochloride-00774936-72-4Lercanidipine Hydrochloride-01488712-56-5Lercanidipine Hydrochloride-024—Lercanidipine Hydrochloride-025887769-40-6Lercanidipine Hydrochloride-02620017-67-8Lercanidipine Hydrochloride-02723808-47-1Lercanidipine Hydrochloride-028957215-03-1API · 缬沙坦/盐酸乐卡地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Lercanidipine Hydrochloride-007 | 74936-72-4 | (+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid |
| Lercanidipine Hydrochloride-014 | 88712-56-5 | 5-(Chlorocarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid methyl ester |
| Lercanidipine Hydrochloride-024 | - | 2-Methyl-1-(methylamino)propan-2-ol p-toluenesulfonate |
| Lercanidipine Hydrochloride-025 | 887769-40-6 | 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 1,1-dimethyl-2-(methylamino)ethyl methyl ester |
| Lercanidipine Hydrochloride-026 | 20017-67-8 | 3,3-Diphenylpropan-1-ol |
| Lercanidipine Hydrochloride-027 | 23808-47-1 | 4-Methylbenzenesulfonic acid 3,3-diphenylpropyl ester |
| Lercanidipine Hydrochloride-028 | 957215-03-1 | 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 2-[N-(3,3-diphenylpropyl)-N-methylamino]-1,1-dimethylethyl methyl diester oxalate |
优化Route 6步骤 5 · 总收率 /
Lercanidipine Hydrochloride-029140-10-3Lercanidipine Hydrochloride-030102-92-1Lercanidipine Hydrochloride-02174-89-5Lercanidipine Hydrochloride-0312757-10-0Lercanidipine Hydrochloride-03271-43-2Lercanidipine Hydrochloride-022348607-76-1Lercanidipine Hydrochloride-01628075-29-8Lercanidipine Hydrochloride-009558-42-9Lercanidipine Hydrochloride-002100442-33-9Lercanidipine Hydrochloride-033—Lercanidipine Hydrochloride-00774936-72-4API · 缬沙坦/盐酸乐卡地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Lercanidipine Hydrochloride-029 | 140-10-3 | 3-Phenyl-2(E)-propenoic acid |
| Lercanidipine Hydrochloride-030 | 102-92-1 | (2E)-3-phenylprop-2-enoyl chloride |
| Lercanidipine Hydrochloride-021 | 74-89-5 | Methylamine |
| Lercanidipine Hydrochloride-031 | 2757-10-0 | N-Methyl-3-phenylacrylamide |
| Lercanidipine Hydrochloride-032 | 71-43-2 | Benzene |
| Lercanidipine Hydrochloride-022 | 348607-76-1 | N-Methyl-3,3-diphenylpropanamide |
| Lercanidipine Hydrochloride-016 | 28075-29-8 | (3,3-Diphenylpropyl)(methyl)amine |
| Lercanidipine Hydrochloride-009 | 558-42-9 | 1-Chloro-2-methyl-2-propanol |
| Lercanidipine Hydrochloride-002 | 100442-33-9 | 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol |
| Lercanidipine Hydrochloride-033 | - | Methyl 5-[[(diethoxyphosphoryl)oxy]carbonyl]-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate |
| Lercanidipine Hydrochloride-007 | 74936-72-4 | (+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid |
优化Route 7步骤 9 · 总收率 /
Lercanidipine Hydrochloride-001674-82-8Lercanidipine Hydrochloride-034109-78-4Lercanidipine Hydrochloride-03565193-87-5Lercanidipine Hydrochloride-00499-61-6Lercanidipine Hydrochloride-00614205-39-1Lercanidipine Hydrochloride-03675130-24-4Lercanidipine Hydrochloride-00774936-72-4Lercanidipine Hydrochloride-002100442-33-9API · 缬沙坦/盐酸乐卡地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Lercanidipine Hydrochloride-001 | 674-82-8在售 | 4-Methylene-2-oxetanone |
| Lercanidipine Hydrochloride-034 | 109-78-4在售 | 1-Cyano-2-hydroxyethane |
| Lercanidipine Hydrochloride-035 | 65193-87-5在售 | 2-Cyanoethyl 3-oxobutanoate |
| Lercanidipine Hydrochloride-004 | 99-61-6 | (3-Nitrophenyl)methanone |
| Lercanidipine Hydrochloride-006 | 14205-39-1 | 3-Amino-2-butenoic acid methyl ester |
| Lercanidipine Hydrochloride-036 | 75130-24-4 | 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(2-cyanoethyl)5-methyl ester |
| Lercanidipine Hydrochloride-007 | 74936-72-4 | (+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid |
| Lercanidipine Hydrochloride-002 | 100442-33-9 | 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol |
优化Route 8步骤 3 · 总收率 /
Lercanidipine Hydrochloride-002100442-33-9Lercanidipine Hydrochloride-0375394-63-8Lercanidipine Hydrochloride-038—Lercanidipine Hydrochloride-003100427-51-8Lercanidipine Hydrochloride-039—Lercanidipine Hydrochloride-00499-61-6Lercanidipine Hydrochloride-008105-45-3Lercanidipine Hydrochloride-04039562-17-9API · 缬沙坦/盐酸乐卡地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Lercanidipine Hydrochloride-002 | 100442-33-9 | 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol |
| Lercanidipine Hydrochloride-037 | 5394-63-8在售 | 2,2,4-Trimethyl-6-keto-1,3-dioxin |
| Lercanidipine Hydrochloride-038 | - | 3-Oxobutanoyl chloride |
| Lercanidipine Hydrochloride-003 | 100427-51-8 | 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl 3-oxobutanoate |
| Lercanidipine Hydrochloride-039 | - | 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl (2E)-3-aminobut-2-enoate |
| Lercanidipine Hydrochloride-004 | 99-61-6 | (3-Nitrophenyl)methanone |
| Lercanidipine Hydrochloride-008 | 105-45-3在售 | 1-Methoxybutane-1,3-dione |
| Lercanidipine Hydrochloride-040 | 39562-17-9 | (Z)-2-Acetyl-3-(3-nitrophenyl)acrylic acid methyl ester |
优化Route 9步骤 2 · 总收率 /
Lercanidipine Hydrochloride-04121881-77-6Lercanidipine Hydrochloride-04274936-81-5API · 缬沙坦/盐酸乐卡地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Lercanidipine Hydrochloride-041 | 21881-77-6 | Dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| Lercanidipine Hydrochloride-042 | 74936-81-5 | 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid |
优化Route 10步骤 4 · 总收率 /
Lercanidipine Hydrochloride-00499-61-6Lercanidipine Hydrochloride-008105-45-3Lercanidipine Hydrochloride-04321731-17-9Lercanidipine Hydrochloride-04121881-77-6Lercanidipine Hydrochloride-00774936-72-4Lercanidipine Hydrochloride-002100442-33-9Lercanidipine Hydrochloride-044100427-26-7Lercanidipine Hydrochloride-01488712-56-5Lercanidipine Hydrochloride-01628075-29-8Lercanidipine Hydrochloride-009558-42-9API · 缬沙坦/盐酸乐卡地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Lercanidipine Hydrochloride-004 | 99-61-6 | (3-Nitrophenyl)methanone |
| Lercanidipine Hydrochloride-008 | 105-45-3在售 | 1-Methoxybutane-1,3-dione |
| Lercanidipine Hydrochloride-043 | 21731-17-9 | (Z)-Methyl 3-aminobut-2-enoate |
| Lercanidipine Hydrochloride-041 | 21881-77-6 | Dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| Lercanidipine Hydrochloride-007 | 74936-72-4 | (+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid |
| Lercanidipine Hydrochloride-002 | 100442-33-9 | 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol |
| Lercanidipine Hydrochloride-044 | 100427-26-7 | 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| Lercanidipine Hydrochloride-014 | 88712-56-5 | 5-(Chlorocarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid methyl ester |
| Lercanidipine Hydrochloride-016 | 28075-29-8 | (3,3-Diphenylpropyl)(methyl)amine |
| Lercanidipine Hydrochloride-009 | 558-42-9 | 1-Chloro-2-methyl-2-propanol |
优化Route 11步骤 4 · 总收率 /
Lercanidipine Hydrochloride-045141-97-9Lercanidipine Hydrochloride-034109-78-4Lercanidipine Hydrochloride-03565193-87-5Lercanidipine Hydrochloride-00499-61-6Lercanidipine Hydrochloride-04675130-34-6Lercanidipine Hydrochloride-04274936-81-5API · 缬沙坦/盐酸乐卡地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Lercanidipine Hydrochloride-045 | 141-97-9在售 | Acetoacetic ethyl ester |
| Lercanidipine Hydrochloride-034 | 109-78-4在售 | 3-Hydroxypropionitrile |
| Lercanidipine Hydrochloride-035 | 65193-87-5在售 | 2-Cyanoethyl 3-oxobutanoate |
| Lercanidipine Hydrochloride-004 | 99-61-6 | m-Nitrobenzaldehyde |
| Lercanidipine Hydrochloride-046 | 75130-34-6 | Bis(2-cyanoethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| Lercanidipine Hydrochloride-042 | 74936-81-5 | 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid |
优化Route 12步骤 5 · 总收率 /
Lercanidipine Hydrochloride-008105-45-3Lercanidipine Hydrochloride-002100442-33-9Lercanidipine Hydrochloride-003100427-51-8Lercanidipine Hydrochloride-00499-61-6Lercanidipine Hydrochloride-005100427-54-1Lercanidipine Hydrochloride-00614205-39-1Lercanidipine Hydrochloride-044100427-26-7API · 缬沙坦/盐酸乐卡地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Lercanidipine Hydrochloride-008 | 105-45-3在售 | 1-Methoxybutane-1,3-dione |
| Lercanidipine Hydrochloride-002 | 100442-33-9 | 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol |
| Lercanidipine Hydrochloride-003 | 100427-51-8 | 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl 3-oxobutanoate |
| Lercanidipine Hydrochloride-004 | 99-61-6 | (3-Nitrophenyl)methanone |
| Lercanidipine Hydrochloride-005 | 100427-54-1 | 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl (2Z)-2-[(3-nitrophenyl)methylidene]-3-oxobutanoate |
| Lercanidipine Hydrochloride-006 | 14205-39-1 | 3-Amino-2-butenoic acid methyl ester |
| Lercanidipine Hydrochloride-044 | 100427-26-7 | 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
优化Route 13步骤 4 · 总收率 /
Lercanidipine Hydrochloride-04798-86-2Lercanidipine Hydrochloride-048593-51-1Lercanidipine Hydrochloride-04927152-62-1Lercanidipine Hydrochloride-05042142-52-9Lercanidipine Hydrochloride-03271-43-2Lercanidipine Hydrochloride-051—API · 缬沙坦/盐酸乐卡地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Lercanidipine Hydrochloride-047 | 98-86-2 | 1-Phenylethan-1-one |
| Lercanidipine Hydrochloride-048 | 593-51-1 | Methanamine hydrochloride |
| Lercanidipine Hydrochloride-049 | 27152-62-1 | 3-(Methylamino)-1-phenylpropan-1-one |
| Lercanidipine Hydrochloride-050 | 42142-52-9 | (+/-)-n-Methyl-3-hydroxy-3-phenylpropylamine |
| Lercanidipine Hydrochloride-032 | 71-43-2 | Benzene |
| Lercanidipine Hydrochloride-051 | - | N-(3,3-Diphenylpropyl)-N-methylamine hydrochloride |
优化Route 14步骤 5 · 总收率 /
Lercanidipine Hydrochloride-008105-45-3Lercanidipine Hydrochloride-034109-78-4Lercanidipine Hydrochloride-03565193-87-5Lercanidipine Hydrochloride-052—Lercanidipine Hydrochloride-00499-61-6Lercanidipine Hydrochloride-03675130-24-4API · 缬沙坦/盐酸乐卡地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Lercanidipine Hydrochloride-008 | 105-45-3在售 | Methyl acetoacetate |
| Lercanidipine Hydrochloride-034 | 109-78-4在售 | 3-Hydroxypropionitrile |
| Lercanidipine Hydrochloride-035 | 65193-87-5在售 | 2-Cyanoethyl 3-oxobutanoate |
| Lercanidipine Hydrochloride-052 | - | (E)-2-cyanoethyl 3-aminobut-2-enoate |
| Lercanidipine Hydrochloride-004 | 99-61-6 | 3-Nitrobenzaldehyde |
| Lercanidipine Hydrochloride-036 | 75130-24-4 | 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-(2-Cyanoethyl) 5-Methyl E |
常见问题（FAQ）
缬沙坦/盐酸乐卡地平的适应症有哪些？
已批准的适应症包括：原发性高血压。
缬沙坦/盐酸乐卡地平的专利什么时候到期？
缬沙坦/盐酸乐卡地平的专利到期年暂无公开口径，本页会在数据管道核实后更新。
缬沙坦/盐酸乐卡地平有几条合成路线？
本站收录 17 条合成路线，最短路线 2 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
缬沙坦/盐酸乐卡地平的关键中间体在哪里可以采购？
缬沙坦/盐酸乐卡地平的多条路线中间体已挂接 CAS 档案，其中 7 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取缬沙坦/盐酸乐卡地平中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22