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CAS 95-92-1
Oxalic acid diethyl diesterdiethyl oxalateEthyl 2-ethoxy-2-oxoacetate
登记编号：Enalapril-025、GRAZ-002、Cilastatin Sodium-014、LPHE-002
应用背景（按来源药适应症）
心脏和血管疾病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高血压阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高脂血症阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利心脏病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利丙型肝炎Grazoprevir HydrateHIV感染Grazoprevir Hydrate慢性丙型肝炎Grazoprevir Hydrate肾功能不全Grazoprevir Hydrate原发性高血压马来酸依那普利/叶酸心脏衰竭马来酸依那普利高血压马来酸依那普利心肌梗塞马来酸依那普利心绞痛马来酸依那普利左心室功能不全马来酸依那普利实体瘤马来酸依那普利传染性疾病西司他丁钠晕动病左旋盐酸苯环壬酯脑梗死左旋盐酸苯环壬酯眩晕左旋盐酸苯环壬酯
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C · 观察 / 贸易 | - |
| Grazoprevir Hydrate | Tier C · 观察 / 贸易 | - |
| 马来酸依那普利/叶酸Enalapril Maleate/Folic Acid | Tier C · 观察 / 贸易 | - |
| 马来酸依那普利Enalapril Maleate | Tier C · 观察 / 贸易 | - |
| 西司他丁钠Cilastatin Sodium | Tier C · 观察 / 贸易 | - |
| 左旋盐酸苯环壬酯L-Phencynonate Hydrochloride | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(2-Bromoethyl)benzene→Bromido(2-phenylethyl)magnesium→Oxalic acid diethyl diester→2-Oxo-4-phenylbutyric acid ethyl ester→4,5-Ditritium-L-proline→L-Alanine→N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanine→N-Hydroxysuccinimide→Ethyl 2-([(2S)-1-[(2,5-dioxopyrrolidin-1-yl)oxy]-1-oxopropan-2-yl]amino)-4-phenylbutanoate→N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl-4,5-ditritium-L-proline→(2Z)-But-2-enedioic acid N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-4,5-ditritium-L-proline
4-methoxybenzene-1,2-diamine dihydrochloride→diethyl oxalate→6-methoxyquinoxaline-2,3-diol→3-chloro-7-methoxyquinoxalin-2-ol→(2S,4S)-1-tert-butyl 2-methyl 4-(((4-bromophenyl)sulfonyl)oxy)pyrrolidine-1,2-dicarboxylate→1-(tert-butyl) 2-methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)pyrrolidine-1,2-dicarboxylate→methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)pyrrolidine-2-carboxylate hydrochloride→(R)-3,3-dimethyl-2-((((1R,2R)-2-(pent-4-en-1-yl)cyclopropoxy)carbonyl)amino)butanoic acid→methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-1-((S)-3,3-dimethyl-2-((((1R,2R)-2-(pent-4-en-1-yl)cyclopropoxy)carbonyl)amino)butanoyl)pyrrolidine-2-carboxylate→potassium trifluoro(vinyl)borate→methyl (2S,4R)-1-((S)-3,3-dimethyl-2-((((1R,2R)-2-(pent-4-en-1-yl)cyclopropoxy)carbonyl)amino)butanoyl)-4-((7-methoxy-3-vinylquinoxalin-2-yl)oxy)pyrrolidine-2-carboxylate→GRAZ-012→methyl (33R,35S,91R,92R,5S,E)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphan-13-ene-35-carboxylate→methyl (33R,35S,91R,92R,5S)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxylate→(33R,35S,91R,92R,5S)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxylic acid→(1R,2S)-1-amino-N-(cyclopropylsulfonyl)-2-vinylcyclopropanecarboxamide hydrochloride→(33R,35S,91R,92R,5S)-5-(tert-butyl)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxamide→but-3-en-1-ylmagnesium bromide→acrylaldehyde→(E)-(hepta-1,6-dien-1-yloxy)trimethylsilane→trimethyl(2-(pent-4-en-1-yl)cyclopropoxy)silane→2-(pent-4-en-1-yl)cyclopropan-1-ol→(1R,2R)-2-(pent-4-en-1-yl)cyclopropyl acetate→(1R,2R)-2-(pent-4-en-1-yl)cyclopropan-1-ol→methyl (S)-2-isocyanato-3,3-dimethylbutanoate→methyl (S)-3,3-dimethyl-2-((((1R,2R)-2-(pent-4-en-1-yl)cyclopropoxy)carbonyl)amino)butanoate
diethyl oxalate→methyl (33R,35S,91R,92R,5S,E)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphan-13-ene-35-carboxylate→methyl (33R,35S,91R,92R,5S)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxylate→but-3-en-1-ylmagnesium bromide→(1R,2R)-2-(pent-2-yn-1-yl)cyclopropan-1-ol→(R)-3,3-dimethyl-2-((((1R,2R)-2-(pent-2-yn-1-yl)cyclopropoxy)carbonyl)amino)butanoic acid→ethyl 2-oxohex-5-enoate→4-methoxybenzene-1,2-diamine→3-(but-3-en-1-yl)-7-methoxyquinoxalin-2-ol→2-(but-3-en-1-yl)-3-chloro-6-methoxyquinoxaline→1-(tert-butyl) 2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate→1-(tert-butyl) 2-methyl (2S,4R)-4-((3-(but-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)pyrrolidine-1,2-dicarboxylate→methyl (2S,4R)-4-((3-(but-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)pyrrolidine-2-carboxylate→(S)-3,3-dimethyl-2-((((1R,2R)-2-((Z)-pent-2-en-1-yl)cyclopropoxy)carbonyl)amino)butanoic acid→methyl (2S,4R)-4-((3-(but-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)-1-((S)-3,3-dimethyl-2-((((1R,2R)-2-((Z)-pent-2-en-1-yl)cyclopropoxy)carbonyl)amino)butanoyl)pyrrolidine-2-carboxylate→GRAZ-042
(2-Bromoethyl)benzene→Bromido(2-phenylethyl)magnesium→Oxalic acid diethyl diester→2-Oxo-4-phenylbutyric acid ethyl ester→4,5-Ditritium-L-proline→L-Alanine→N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanine→N-Hydroxysuccinimide→Ethyl 2-([(2S)-1-[(2,5-dioxopyrrolidin-1-yl)oxy]-1-oxopropan-2-yl]amino)-4-phenylbutanoate→N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl-4,5-ditritium-L-proline→(2Z)-But-2-enedioic acid N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-4,5-ditritium-L-proline
(2-Bromoethyl)benzene→Bromido(2-phenylethyl)magnesium→Oxalic acid diethyl diester→2-Oxo-4-phenylbutyric acid ethyl ester→4,5-Ditritium-L-proline→L-Alanine→N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanine→N-Hydroxysuccinimide→Ethyl 2-([(2S)-1-[(2,5-dioxopyrrolidin-1-yl)oxy]-1-oxopropan-2-yl]amino)-4-phenylbutanoate→N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl-4,5-ditritium-L-proline→(2Z)-But-2-enedioic acid N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-4,5-ditritium-L-proline
本站可供应的对应中间体
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