CAS 74-88-4

Iodomethaneiodomethane-11CMethyl iodide

Codes: (I)270899-4-a, LACO-011, (XXXIV)638294-1-d, (XXXVI)101438-55-d, Ephedrine Sulfate-019, Clarithromycin-025, Desvenlafaxine-024, (X)1225102-1-a, (IV)909096-2-a, (XXIX)796686-1-d, (XXXIII)145089-2-d, Granisetron-009 +3 more

Application context (from source-drug indications)

Major depressive disorderEsketamine HydrochlorideSuicidal ideationEsketamine HydrochlorideDepressive disorderEsketamine HydrochlorideAnaesthesiaEsketamine HydrochlorideTreatment-resistant depressionEsketamine HydrochloridePainEsketamine HydrochlorideTonic-clonic seizureLacosamideEpilepsyLacosamidePartial-onset seizureLacosamideSeizureLacosamideSystolic heart failureFinerenoneDiastolic heart failureFinerenoneHeart failureFinerenoneChronic renal impairmentFinerenoneDiabetic nephropathyFinerenoneType 2 diabetesFinerenoneBreast cancerPaclitaxel/Encequidar mesylateAdenocarcinomaPaclitaxel/Encequidar mesylateAngiosarcomaPaclitaxel/Encequidar mesylateSolid tumourPaclitaxel/Encequidar mesylateHypotensionEphedrine SulfateMarginal zone B-cell lymphomaClarithromycin/Rabeprazole Sodium/AmoxicillinDuodenal ulcerClarithromycin/Rabeprazole Sodium/AmoxicillinImmune thrombocytopenic purpuraClarithromycin/Rabeprazole Sodium/AmoxicillinGastric ulcerClarithromycin/Rabeprazole Sodium/AmoxicillinGastritisClarithromycin/Rabeprazole Sodium/AmoxicillinHelicobacter pylori infectionClarithromycin/Rabeprazole Sodium/AmoxicillinMajor depressive disorderDesvenlafaxineDepressive disorderDesvenlafaxinePancreatic cancerPaclitaxelNon-small cell lung cancerPaclitaxelHodgkin's diseasePaclitaxelSeminomaPaclitaxelOvarian cancerPaclitaxelBreast cancerPaclitaxelSinusitisClarithromycinTonsillitisClarithromycinAcute bronchitisClarithromycinChronic bronchitisClarithromycinLower respiratory tract infectionClarithromycinPharyngitisClarithromycinNon-small cell lung cancerFulzerasibColorectal cancerFulzerasibSolid tumourFulzerasibNon-small cell lung cancerIruplinalkib侵袭性念珠菌病Rezafungin acetateCandidiasisRezafungin acetateCandidaemiaRezafungin acetate卡氏肺囊虫感染Rezafungin acetate侵袭性真菌感染Rezafungin acetateAspergillus infectionRezafungin acetateAlzheimer's diseaseRivastigmine TartrateDementiaRivastigmine TartrateParkinson's diseaseRivastigmine Tartrate抗胆碱能综合征Rivastigmine Tartrate神经行为学表现Rivastigmine TartrateCognitive impairmentRivastigmine TartrateChemotherapy-induced nausea and vomitingGranisetronNauseaGranisetron呕吐Granisetron手术后恶心呕吐GranisetronPostoperative painGranisetronGastroparesisGranisetronNon-small cell lung cancerZongertinibLung cancerZongertinib食道腺癌Zongertinib食管胃结合部肿瘤ZongertinibGastric cancerZongertinibMetastatic breast cancerZongertinibHot flushesElinzanetantVasomotor symptomsElinzanetantHR阳性乳腺癌Elinzanetant睡眠障碍ElinzanetantMenopausal symptomsElinzanetantOpioid dependenceElinzanetant

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Esketamine Hydrochloride	Tier B — Position early	2029
Lacosamide	Tier B — Position early	2028
Finerenone	Tier C — Watch / trade	2030
Paclitaxel/Encequidar mesylate	Tier C — Watch / trade	-
Ephedrine Sulfate	Tier C — Watch / trade	-
Clarithromycin/Rabeprazole Sodium/Amoxicillin	Tier C — Watch / trade	-
Desvenlafaxine	Tier C — Watch / trade	-
Paclitaxel	Tier B — Position early	-
Clarithromycin	Tier C — Watch / trade	-
Fulzerasib	Tier C — Watch / trade	-
Iruplinalkib	Tier C — Watch / trade	-
Rezafungin acetate	Tier C — Watch / trade	-
Rivastigmine Tartrate	Tier B — Position early	-
Granisetron	Tier C — Watch / trade	-
Zongertinib	Tier C — Watch / trade	-
Elinzanetant	Tier C — Watch / trade	-
Eptazocine hydrobromide	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Esketamine HydrochlorideOptimised routesteps: 6total yield: /

Iodomethane→Chlorocyclopentane→1-Chloro-2-cyanobenzene→(2-Chlorophenyl)(cyclopentyl)methanone→2-Chlorobenzoyl chloride→Cyclopentene→(1-Bromocyclopentyl)(2-chlorophenyl) ketone→Aminomethane→1-[(E)-(2-Chlorophenyl)(methylimino)methyl]cyclopentan-1-ol hydrogen chloride→(±)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride→2-(2-Chlorophenyl)-2-(methylamino)cyclohexan-1-one→(2S)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone

LacosamideOptimised routesteps: 4total yield: 10.5 g

(tert-butoxycarbonyl)-D-serine→iodomethane-11C→N-(tert-butoxycarbonyl)-O-methyl-D-serine→O-methyl-D-serine→N-acetyl-O-methyl-D-serine

FinerenoneOptimised routesteps: 4total yield: /

2-Methoxy-4-cyanobenzaldehyde→3-Methoxy-4-methylbenzonitrile→3-Carboxyphenol→3-Hydroxybenzamide→3-Cyanophenol→Formaldehyde→4-Cyano-2-hydroxybenzaldehyde→Dimethoxysulfone→Iodomethane→2-Fluoro-4-cyanotoluene→Hydroxymethane→4-Bromo-3-methoxybenzamide→2-Methoxy-4-cyanobromobenzene

Paclitaxel/Encequidar mesylateOptimised routesteps: 6total yield: /

1,3-Dihydroxy-2,2-dimethylpropane→2,2-Dimethylcyclohexane-1,3-dione→2,2,4-Trimethylcyclohex-3-en-1-one→2,4,6-Triisopropyl-N'-[(1Z)-2,2,4-trimethylcyclohex-3-en-1-ylidene]benzenesulfonohydrazide→2,4,6-Triisopropylbenzenesulfonohydrazide→3,3,7,7-Tetramethyl-1,5-dioxaspiro[5.5]undecan-8-one→3,3,7,7,9-Pentamethyl-1,5-dioxaspiro[5.5]undec-8-ene→3,5-Cyclohexanedione→4-Methyl-N'-[(8E)-3,3,7,7-tetramethyl-1,5-dioxaspiro[5.5]undec-8-ylidene]benzenesulfonohydrazide→4-Methylbenzenesulfonhydrazide→Iodomethane

Ephedrine SulfateOptimised routesteps: 9total yield: /

Cinnamyl alcohol→(±)-3-(Benzyloxy)-2-bromo-3-phenylpropan-1-ol→(±)-2-[(Benzyloxy)(phenyl)methyl]oxirane→(2R)-2-[(R)-(Benzyloxy)(phenyl)methyl]oxirane→(1R,2R)-1-(Benzyloxy)-1-phenylpropan-2-ol→(1R,2R)-1-(Benzyloxy)-1-phenylpropan-2-yl methanesulfonate→[(1R,2S)-2-Azido-1-(benzyloxy)propyl]benzene→Benzyl [(1R,2S)-1-(benzyloxy)-1-phenylpropan-2-yl]carbamate→Methyl iodide→Benzyl [(1R,2S)-1-(benzyloxy)-1-phenylpropan-2-yl]methylcarbamate→(-)-2(S)-(Methylamino)-1(R)-phenylpropan-1-ol

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Taizhou GMP-like Site	N-Boc-O-Benzyl-D-serine Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-amine hydrochloride Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	N-[6-Chloro-4-(4-fluoro-2-methylp henyl)-3-pyridinyl]-N,a,a-trimethy Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	3-Morpholinemethanol, 4-(phenylmethyl)-, hydrochloride Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	(7S,9aS)-7-((Benzyloxy)methyl)octahydropyrazino[2,1-c][1,4]oxazine dioxalate salt Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	((7S)-octahydropyrazino[2,1-c][1,4]oxazin-7-yl)methanol Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	4-Boc-3-morpholinecarboxylic Acid Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	2-(3,5-bis-trifluoromethylphenyl)-2-methyl-propionyl chloride Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	4-Bromo-2-methoxybenzaldehyde Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	4-AMino-5-Methylpyridin-2-ol Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	2-chloro-5-methylpyridin-4-amine Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.