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CAS 885618-31-5
2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde
Codes: BEBT-908-005, FIMEP-005
Application context (from source-drug indications)
Diffuse large B-cell lymphomaIfupinostat Hydrochloride大B细胞淋巴瘤Ifupinostat HydrochloridePeripheral T-cell lymphomaIfupinostat HydrochlorideNon-small cell lung cancerIfupinostat HydrochlorideBreast cancerIfupinostat HydrochlorideMetastatic breast cancerIfupinostat HydrochlorideCushing's syndromeFimepinostatGliomaFimepinostatGlioblastomaFimepinostatDiffuse intrinsic pontine gliomaFimepinostat髓母细胞瘤Fimepinostat星形细胞瘤Fimepinostat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ifupinostat Hydrochloride | Tier C — Watch / trade | - |
| Fimepinostat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
N-hydroxy-2-(methyl((2-(6-(methylamino)pyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)amino)pyrimidine-5-carboxamide trihydrochloride→methyl 3-aminothiophene-2-carboxylate→thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione→2,4-dichlorothieno[3,2-d]pyrimidine→4-(2-chlorothieno[3,2-d]pyrimidin-4-yl)morpholine→2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde→1-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-methylmethanamine→ethyl 2-chloropyrimidine-5-carboxylate→ethyl 2-(((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate→(6-(methylamino)pyridin-3-yl)boronic acid hydrochloride→ethyl 2-(methyl((2-(6-(methylamino)pyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)amino)pyrimidine-5-carboxylate→N-hydroxy-2-(methyl((2-(6-(methylamino)pyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)amino)pyrimidine-5-carboxamide→2,5-dibromopyridine→5-bromo-N-methylpyridin-2-amine→tert-butyl (5-bromopyridin-2-yl)(methyl)carbamate
methyl 3-aminothiophene-2-carboxylate→thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione→FIMEP-003→FIMEP-004→2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde→1-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-methylmethanamine→ethyl 2-chloropyrimidine-5-carboxylate→ethyl 2-(((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate→(6-methoxypyridin-3-yl)boronic acid→FIMEP-010→FIMEP-011→FIMEP-012→FIMEP-013→FIMEP-014→2-methoxypyridine→5-bromo-2-methoxypyridine→Fimepinostat
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