← Back to patent-cliff list
CAS 89793-12-4
ethyl 2-chloropyrimidine-5-carboxylate
Codes: AVAPR-001, BEBT-908-007, FIMEP-007
Application context (from source-drug indications)
Systemic mastocytosisAvapritinibGastrointestinal stromal tumourAvapritinibMast cell leukaemiaAvapritinibDiffuse large B-cell lymphomaIfupinostat Hydrochloride大B细胞淋巴瘤Ifupinostat HydrochloridePeripheral T-cell lymphomaIfupinostat HydrochlorideNon-small cell lung cancerIfupinostat HydrochlorideBreast cancerIfupinostat HydrochlorideMetastatic breast cancerIfupinostat HydrochlorideCushing's syndromeFimepinostatGliomaFimepinostatGlioblastomaFimepinostatDiffuse intrinsic pontine gliomaFimepinostat髓母细胞瘤Fimepinostat星形细胞瘤Fimepinostat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Avapritinib | Tier C — Watch / trade | 2032 |
| Ifupinostat Hydrochloride | Tier C — Watch / trade | - |
| Fimepinostat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine→6-bromopyrrolo[2,1-f][1,2,4]triazin-4(3H)-one→1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole→6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one→(S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine→ethyl 2-chloropyrimidine-5-carboxylate→tert-butyl piperazine-1-carboxylate→ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrimidine-5-carboxylate→2-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrimidine-5-carboxylic acid→N,O-dimethylhydroxylamine→tert-butyl 4-(5-(methoxy(methyl)carbamoyl)pyrimidin-2-yl)piperazine-1-carboxylate→(4-fluorophenyl)magnesium bromide→tert-butyl 4-(5-(4-fluorobenzoyl)pyrimidin-2-yl)piperazine-1-carboxylate→(4-fluorophenyl)(2-(piperazin-1-yl)pyrimidin-5-yl)methanone hydrochloride→4-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazine→(4-fluorophenyl)(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)methanone→(S)-2-methylpropane-2-sulfinamide→(Z)-N-((4-fluorophenyl)(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)methylene)-2-methylpropane-2-sulfinamide→N-(1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethyl)-2-methylpropane-2-sulfinamide
N-hydroxy-2-(methyl((2-(6-(methylamino)pyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)amino)pyrimidine-5-carboxamide trihydrochloride→methyl 3-aminothiophene-2-carboxylate→thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione→2,4-dichlorothieno[3,2-d]pyrimidine→4-(2-chlorothieno[3,2-d]pyrimidin-4-yl)morpholine→2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde→1-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-methylmethanamine→ethyl 2-chloropyrimidine-5-carboxylate→ethyl 2-(((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate→(6-(methylamino)pyridin-3-yl)boronic acid hydrochloride→ethyl 2-(methyl((2-(6-(methylamino)pyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)amino)pyrimidine-5-carboxylate→N-hydroxy-2-(methyl((2-(6-(methylamino)pyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)amino)pyrimidine-5-carboxamide→2,5-dibromopyridine→5-bromo-N-methylpyridin-2-amine→tert-butyl (5-bromopyridin-2-yl)(methyl)carbamate
methyl 3-aminothiophene-2-carboxylate→thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione→FIMEP-003→FIMEP-004→2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde→1-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-methylmethanamine→ethyl 2-chloropyrimidine-5-carboxylate→ethyl 2-(((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate→(6-methoxypyridin-3-yl)boronic acid→FIMEP-010→FIMEP-011→FIMEP-012→FIMEP-013→FIMEP-014→2-methoxypyridine→5-bromo-2-methoxypyridine→Fimepinostat
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | Ethyl 2-chloropyrimidine-5-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.