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CAS 593-51-1
Methanamine hydrochlorideAminomethane hydrochloride
登记编号：Lercanidipine Hydrochloride-048、(XIII)859946-1-a、Granisetron-013
应用背景（按来源药适应症）
原发性高血压缬沙坦/盐酸乐卡地平高血压盐酸乐卡地平胆道癌他舒替尼胆管癌他舒替尼实体瘤他舒替尼胆管上皮癌他舒替尼乳腺癌他舒替尼肝功能衰退他舒替尼化疗导致的恶心和呕吐格拉司琼恶心格拉司琼呕吐格拉司琼手术后恶心呕吐格拉司琼术后疼痛格拉司琼胃肌轻瘫格拉司琼
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 缬沙坦/盐酸乐卡地平Valsartan/Lercanidipine Hydrochloride | Tier C · 观察 / 贸易 | - |
| 盐酸乐卡地平Lercanidipine Hydrochloride | Tier C · 观察 / 贸易 | - |
| 他舒替尼Tasurgratinib | Tier C · 观察 / 贸易 | - |
| 格拉司琼Granisetron | Tier C · 观察 / 贸易 | - |
| 氢溴酸依他佐辛Eptazocine hydrobromide | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-Phenylethan-1-one→Methanamine hydrochloride→3-(Methylamino)-1-phenylpropan-1-one→(+/-)-n-Methyl-3-hydroxy-3-phenylpropylamine→Benzene→N-(3,3-Diphenylpropyl)-N-methylamine hydrochloride
1-Phenylethan-1-one→Methanamine hydrochloride→3-(Methylamino)-1-phenylpropan-1-one→(+/-)-n-Methyl-3-hydroxy-3-phenylpropylamine→Benzene→N-(3,3-Diphenylpropyl)-N-methylamine hydrochloride
3,4-Dihydroxybenzaldehyde→1-Bromo-2-methoxyethane→3-Hydroxy-4-(2-methoxyethoxy)benzaldehyde→3-(Benzyloxy)-4-(2-methoxyethoxy)benzaldehyde→Nitrocarbol→2-(Benzyloxy)-1-(2-methoxyethoxy)-4-[(E)-2-nitroethenyl]benzene→6-(2-Methoxyethoxy)-1H-indol-5-ol→N-(4-Chloropyridin-2-yl)acetamide→2-Amino-4-chloropyridine→N-(4-[[6-(2-Methoxyethoxy)-1H-indol-5-yl]oxy]pyridin-2-yl)acetamide→4-[[6-(2-Methoxyethoxy)-1H-indol-5-yl]oxy]pyridin-2-amine→Phenyl methylcarbamate→Aminomethane hydrochloride→Carbonochloridic acid phenyl ester→1,4-Dioxane-2,5-diol→5-[(2-Aminopyridin-4-yl)oxy]-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide→4-[1-(tert-Butoxycarbonyl)piperidin-4-yl]benzoic acid→6-(2-Methoxyethoxy)-N-methyl-5-([2-[4-(piperidin-4-yl)benzamido]pyridin-4-yl]oxy)-1H-indole-1-carboxamide→2-Oxidanylethanal
2,3-Indolinedione→Iodomethane→1-Methyl-1H-indole-2,3-dione→3,3-Dimethoxy-1-methyl-1,3-dihydro-2H-indol-2-one→1-Methylindazole-3-carboxylic acid→1-Methyl-1H-indazole-3-carbonyl chloride→endo-9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine→Glutaraldehyde→Methanamine hydrochloride→1,3-Acetonedicarboxylic acid→9-Methyl-9-azabicyclo[3.3.1]nonan-3-one→Hydroxylamine hydrochloride→N-Hydroxy-9-methyl-9-azabicyclo[3.3.1]nonan-3-imine→1-Methyl-2,3-dihydro-1H-indole
3-Benzyloxyiodobenzene→6-Iodo-3-methylhex-2(Z)-en-1-ol→[7-(Benzyloxy)-1-methyl-1,2,3,4-tetrahydronaphthalen-1-yl]acetaldehyde→Methanamine hydrochloride→1,4-Dimethyl-2,3,4,5,6,7-hexahydro-1H-1,6-methano-4-benzazonin-10-ol hydrogen bromide→2-[7-(Benzyloxy)-1-methyl-1,2,3,4-tetrahydronaphthalen-1-yl]-N-methylethan-1-amine→10-(Benzyloxy)-1,4-dimethyl-1,2,3,4,5,6-hexahydro-7H-1,6-methano-4-benzazonin-7-one→1,4-Dimethyl-2,3,4,5,6,7-hexahydro-1H-1,6-methano-4-benzazonin-10-ol→Formaldehyde
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