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Ioflupane (123I)
Tier C · 观察 / 贸易Ioflupane (123I)
Ge Healthcare
原研
2000
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
放射性产品
类型
靶点：Not applicable
商品名：DaTSCAN、Striascan
适应症（已批准）：路易氏体型失智症、诊断剂、帕金森综合征、阿尔茨海默病、帕金森病
各地区研发/上市状态
美国
批准上市
2011-01-14
欧盟
批准上市
2000-07-27
中国
临床三期
2020-06-28
日本
批准上市
2013-09-20
合成路线与中间体3 routes
原研路线 × 0优化路线（非专利）× 3工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 1步骤 4 · 总收率 /
Ioflupane (123I)-001—Ioflupane (123I)-002—Ioflupane (123I)-003352-91-0Ioflupane (123I)-004—Ioflupane (123I)-005155798-00-8API · Ioflupane (123I)
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Ioflupane (123I)-001 | - | Methyl(2S,3S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate |
| Ioflupane (123I)-002 | - | Methyl(2S,3S)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate |
| Ioflupane (123I)-003 | 352-91-0 | 1-Bromo-3-fluoropropane |
| Ioflupane (123I)-004 | - | Methyl(2S,3S)-8-(3-fluoropropyl)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate |
| Ioflupane (123I)-005 | 155798-00-8 | Methyl(1R,2S,3S,5S)-8-(3-fluoropropyl)-3-[4-(trimethylstannyl)phenyl]-8-azabicyclo[3.2.1]octane-2-carboxylate |
优化Route 2步骤 8 · 总收率 /
Ioflupane (123I)-006532-24-1Ioflupane (123I)-007616-38-6Ioflupane (123I)-00867-56-1Ioflupane (123I)-00936127-17-0Ioflupane (123I)-010106293-60-1Ioflupane (123I)-011127379-24-2Ioflupane (123I)-012106-37-6Ioflupane (123I)-013135367-08-7Ioflupane (123I)-014189950-17-2Ioflupane (123I)-003352-91-0Ioflupane (123I)-015343312-15-2Ioflupane (123I)-005155798-00-8API · Ioflupane (123I)
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Ioflupane (123I)-006 | 532-24-1 | 8-Methyl-8-azabicyclo[3.2.1]octan-3-one |
| Ioflupane (123I)-007 | 616-38-6 | Carbonicaciddimethyldiester |
| Ioflupane (123I)-008 | 67-56-1在售 | Hydroxymethane |
| Ioflupane (123I)-009 | 36127-17-0 | Methyl8-methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylate |
| Ioflupane (123I)-010 | 106293-60-1 | Methyl3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate |
| Ioflupane (123I)-011 | 127379-24-2 | Methyl8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate |
| Ioflupane (123I)-012 | 106-37-6在售 | 1,4-Dibromobenzene |
| Ioflupane (123I)-013 | 135367-08-7 | (±)-Methyl(1R*,2S*,3S*,5S*)-3-(4-bromophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate |
| Ioflupane (123I)-014 | 189950-17-2 | (±)-Methyl(1R*,2S*,3S*,5S*)-3-(4-bromophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate |
| Ioflupane (123I)-003 | 352-91-0 | 1-Bromo-3-fluoropropane |
| Ioflupane (123I)-015 | 343312-15-2 | Methyl(1R,2S,3S,5S)-3-(4-bromophenyl)-8-(3-fluoropropyl)-8-azabicyclo[3.2.1]octane-2-carboxylate |
| Ioflupane (123I)-005 | 155798-00-8 | Methyl(1R,2S,3S,5S)-8-(3-fluoropropyl)-3-[4-(trimethylstannyl)phenyl]-8-azabicyclo[3.2.1]octane-2-carboxylate |
优化Route 3步骤 6 · 总收率 /
Ioflupane (123I)-0161933755-75-9Ioflupane (123I)-017—Ioflupane (123I)-011127379-24-2Ioflupane (123I)-018100-58-3Ioflupane (123I)-019—Ioflupane (123I)-001—Ioflupane (123I)-020—Ioflupane (123I)-021—API · Ioflupane (123I)
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Ioflupane (123I)-016 | 1933755-75-9 | Methyl(2R,3S)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate |
| Ioflupane (123I)-017 | - | Methyl(2R,3S)-3-(benzyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate |
| Ioflupane (123I)-011 | 127379-24-2 | Methyl8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate |
| Ioflupane (123I)-018 | 100-58-3 | Bromo(phenyl)magnesium |
| Ioflupane (123I)-019 | - | Methyl(2S,3S)-8-methyl-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate |
| Ioflupane (123I)-001 | - | Methyl(2S,3S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate |
| Ioflupane (123I)-020 | - | Methyl(2S,3S)-8-methyl-3-[4-(tributylstannyl)phenyl]-8-azabicyclo[3.2.1]octane-2-carboxylate |
| Ioflupane (123I)-021 | - | Methyl(2S,3S)-3-[4-[123I]iodophenyl]-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate |
常见问题（FAQ）
Ioflupane (123I)的适应症有哪些？
已批准的适应症包括：路易氏体型失智症、诊断剂、帕金森综合征、阿尔茨海默病、帕金森病。
Ioflupane (123I)的专利什么时候到期？
Ioflupane (123I)的专利到期年暂无公开口径，本页会在数据管道核实后更新。
Ioflupane (123I)有几条合成路线？
本站收录 3 条合成路线，最短路线 4 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
Ioflupane (123I)的关键中间体在哪里可以采购？
Ioflupane (123I)的多条路线中间体已挂接 CAS 档案，其中 2 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取Ioflupane (123I)中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22