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枸橼酸莫沙必利
Tier C · 观察 / 贸易Mosapride Citrate
大日本住友制药株式会社
原研
1998
首批上市
-
到期年（公开口径）
$0.27B ▲
峰值销售
化学药
类型
靶点：5-HT4
商品名：加斯清、Gasmotin
适应症（已批准）：胃炎
各地区研发/上市状态
美国
-
欧盟
-
中国
批准上市
1999-11-29
日本
批准上市
1998-06-30
合成路线与中间体12 routes
原研路线 × 0优化路线（非专利）× 11工艺路线 × 1
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 1步骤 5 · 总收率 /
Mosapride Citrate-0014093-28-1Mosapride Citrate-00275-03-6Mosapride Citrate-00359-06-3Mosapride Citrate-0044235-43-2Mosapride Citrate-005108282-38-8Mosapride Citrate-006112914-13-3Mosapride Citrate-007112885-41-3API · 枸橼酸莫沙必利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Mosapride Citrate-001 | 4093-28-1 | Methyl 4-(acetylamino)-2-hydroxybenzoate |
| Mosapride Citrate-002 | 75-03-6在售 | 1-Iodoethane |
| Mosapride Citrate-003 | 59-06-3 | methyl 4-acetamido-2-ethoxybenzoate |
| Mosapride Citrate-004 | 4235-43-2 | methyl 5-chloro-4-acetamido-2-ethoxybenzoate |
| Mosapride Citrate-005 | 108282-38-8 | 4-Amino-5-chloro-2-ethoxybenzoic acid |
| Mosapride Citrate-006 | 112914-13-3 | [4-(4-Fluorobenzyl)-2-morpholinyl]methylamine |
| Mosapride Citrate-007 | 112885-41-3 | - |
优化Route 2步骤 4 · 总收率 /
Mosapride Citrate-0082243304-18-7Mosapride Citrate-0092243304-21-2Mosapride Citrate-0101251032-59-3Mosapride Citrate-011—Mosapride Citrate-007112885-41-3Mosapride Citrate-012133-10-8Mosapride Citrate-01350-86-2Mosapride Citrate-01474-96-4Mosapride Citrate-0152486-67-1Mosapride Citrate-0161173203-33-2API · 枸橼酸莫沙必利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Mosapride Citrate-008 | 2243304-18-7 | Sulfuric acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine |
| Mosapride Citrate-009 | 2243304-21-2 | Phosphoric acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine |
| Mosapride Citrate-010 | 1251032-59-3 | 1-[4-[(4-Fluorophenyl)methyl]morpholin-2-yl]methanamine hydrogen chloride |
| Mosapride Citrate-011 | - | 2-Methylpropane-1,2,3-tricarboxylic acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine |
| Mosapride Citrate-007 | 112885-41-3 | - |
| Mosapride Citrate-012 | 133-10-8 | Sodium 4-amino-2-hydroxybenzoate |
| Mosapride Citrate-013 | 50-86-2 | N-Acetyl-4-aminosalicylic acid |
| Mosapride Citrate-014 | 74-96-4 | 1-Bromoethane |
| Mosapride Citrate-015 | 2486-67-1 | Ethyl 4-acetamido-2-ethoxybenzoate |
| Mosapride Citrate-016 | 1173203-33-2 | Ethyl 4-acetamido-5-chloro-2-ethoxybenzoate |
优化Route 3步骤 6 · 总收率 /
Mosapride Citrate-006112914-13-3Mosapride Citrate-0082243304-18-7Mosapride Citrate-0092243304-21-2Mosapride Citrate-0101251032-59-3Mosapride Citrate-011—Mosapride Citrate-017459-57-4Mosapride Citrate-018141-43-5Mosapride Citrate-019—Mosapride Citrate-02022116-33-2Mosapride Citrate-021—Mosapride Citrate-02285-41-6Mosapride Citrate-0231074-82-4Mosapride Citrate-024106-89-8API · 枸橼酸莫沙必利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Mosapride Citrate-006 | 112914-13-3 | [4-(4-Fluorobenzyl)-2-morpholinyl]methylamine |
| Mosapride Citrate-008 | 2243304-18-7 | Sulfuric acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine |
| Mosapride Citrate-009 | 2243304-21-2 | Phosphoric acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine |
| Mosapride Citrate-010 | 1251032-59-3 | 1-[4-[(4-Fluorophenyl)methyl]morpholin-2-yl]methanamine hydrogen chloride |
| Mosapride Citrate-011 | - | 2-Methylpropane-1,2,3-tricarboxylic acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine |
| Mosapride Citrate-017 | 459-57-4 | 4-Fluorobenzaldehyde |
| Mosapride Citrate-018 | 141-43-5在售 | 2-Hydroxyethylamine |
| Mosapride Citrate-019 | - | 2-[(E)-[(4-Fluorophenyl)methylidene]amino]ethan-1-ol |
| Mosapride Citrate-020 | 22116-33-2 | 2-[[(4-Fluorophenyl)methyl]amino]ethan-1-ol |
| Mosapride Citrate-021 | - | 2-[(Oxiran-2-yl)methyl]-1H-isoindole-1,3(2H)-dione |
| Mosapride Citrate-022 | 85-41-6 | 1,3-Dihydro-1,3-dioxoisoindole |
| Mosapride Citrate-023 | 1074-82-4 | 1,3-Dihydro-1,3-dioxoisoindole potassium salt |
| Mosapride Citrate-024 | 106-89-8 | (+/-)-Epichlorohydrin |
优化Route 4步骤 6 · 总收率 /
Mosapride Citrate-006112914-13-3Mosapride Citrate-018141-43-5Mosapride Citrate-02022116-33-2Mosapride Citrate-0231074-82-4Mosapride Citrate-02596-23-1Mosapride Citrate-02619667-37-9Mosapride Citrate-0271190703-91-3Mosapride Citrate-0282377523-96-9Mosapride Citrate-029116143-27-2Mosapride Citrate-030352-11-4API · 枸橼酸莫沙必利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Mosapride Citrate-006 | 112914-13-3 | [4-(4-Fluorobenzyl)-2-morpholinyl]methylamine |
| Mosapride Citrate-018 | 141-43-5在售 | 2-Hydroxyethylamine |
| Mosapride Citrate-020 | 22116-33-2 | 2-[[(4-Fluorophenyl)methyl]amino]ethan-1-ol |
| Mosapride Citrate-023 | 1074-82-4 | 1,3-Dihydro-1,3-dioxoisoindole potassium salt |
| Mosapride Citrate-025 | 96-23-1 | Glycerol-alpha,gamma-dichlorohydrin |
| Mosapride Citrate-026 | 19667-37-9 | N-(3-Chloro-2-hydroxypropyl)-phthalimide |
| Mosapride Citrate-027 | 1190703-91-3 | 2-(3-[[(4-Fluorophenyl)methyl](2-hydroxyethyl)amino]-2-hydroxypropyl)-1H-isoindole-1,3(2H)-dione |
| Mosapride Citrate-028 | 2377523-96-9 | 2-[2-Hydroxy-3-[(2-hydroxyethyl)amino]propyl]-1H-isoindole-1,3(2H)-dione |
| Mosapride Citrate-029 | 116143-27-2 | Morpholin-2-ylmethanamine |
| Mosapride Citrate-030 | 352-11-4 | alpha-Chloro-4-fluorotoluene |
优化Route 5步骤 10 · 总收率 /
Mosapride Citrate-017459-57-4Mosapride Citrate-018141-43-5Mosapride Citrate-02022116-33-2Mosapride Citrate-024106-89-8Mosapride Citrate-031156816-53-4Mosapride Citrate-032156925-17-6Mosapride Citrate-033156816-54-5Mosapride Citrate-034156816-52-3Mosapride Citrate-035—Mosapride Citrate-036—Mosapride Citrate-037156334-90-6Mosapride Citrate-038156334-89-3Mosapride Citrate-005108282-38-8API · 枸橼酸莫沙必利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Mosapride Citrate-017 | 459-57-4 | (4-Fluorophenyl)methanone |
| Mosapride Citrate-018 | 141-43-5在售 | 1-Amino-2-hydroxyethane |
| Mosapride Citrate-020 | 22116-33-2 | 2-(4-Fluorobenzylamino)ethanol |
| Mosapride Citrate-024 | 106-89-8 | (+/-)-2-(Chloromethyl)oxirane |
| Mosapride Citrate-031 | 156816-53-4 | 1-chloro-3-{[(4-fluorophenyl)methyl](2-hydroxyethyl)amino}propan-2-ol |
| Mosapride Citrate-032 | 156925-17-6 | 2-(chloromethyl)-4-[(4-fluorophenyl)methyl]morpholine |
| Mosapride Citrate-033 | 156816-54-5 | {4-[(4-fluorophenyl)methyl]morpholin-2-yl}methanol |
| Mosapride Citrate-034 | 156816-52-3 | {4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl 4-methylbenzene-1-sulfonate |
| Mosapride Citrate-035 | - | [(2S)-4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl phenylmethanesulfonate |
| Mosapride Citrate-036 | - | [(2R)-4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl phenylmethanesulfonate |
| Mosapride Citrate-037 | 156334-90-6 | [(2R)-4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine |
| Mosapride Citrate-038 | 156334-89-3 | [(2S)-4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine |
| Mosapride Citrate-005 | 108282-38-8 | 4-Amino-5-chloro-2-ethoxybenzoic acid |
优化Route 6步骤 4 · 总收率 /
Mosapride Citrate-036—Mosapride Citrate-03914618-80-5Mosapride Citrate-040666-03-5Mosapride Citrate-041135065-70-2Mosapride Citrate-042156925-22-3Mosapride Citrate-030352-11-4Mosapride Citrate-034156816-52-3API · 枸橼酸莫沙必利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Mosapride Citrate-036 | - | [(2R)-4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl phenylmethanesulfonate |
| Mosapride Citrate-039 | 14618-80-5 | (2R)-2-(Phenylmethoxymethyl)oxirane |
| Mosapride Citrate-040 | 666-03-5 | Sodium (2-aminoethyl) sulfate |
| Mosapride Citrate-041 | 135065-70-2 | 2(R)-(Benzyloxymethyl)morpholine |
| Mosapride Citrate-042 | 156925-22-3 | (2R)-morpholin-2-ylmethanol |
| Mosapride Citrate-030 | 352-11-4 | 1-(Chloromethyl)-4-fluorobenzene |
| Mosapride Citrate-034 | 156816-52-3 | {4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl 4-methylbenzene-1-sulfonate |
优化Route 7步骤 6 · 总收率 /
Mosapride Citrate-02022116-33-2Mosapride Citrate-043920-37-6Mosapride Citrate-044172419-86-2Mosapride Citrate-045172419-87-3Mosapride Citrate-033156816-54-5Mosapride Citrate-02285-41-6Mosapride Citrate-046636582-78-0Mosapride Citrate-037156334-90-6Mosapride Citrate-005108282-38-8API · 枸橼酸莫沙必利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Mosapride Citrate-020 | 22116-33-2 | 2-(4-Fluorobenzylamino)ethanol |
| Mosapride Citrate-043 | 920-37-6 | 2-Chloro-2-propenonitrile |
| Mosapride Citrate-044 | 172419-86-2 | 4-[(4-fluorophenyl)methyl]morpholine-2-carbonitrile |
| Mosapride Citrate-045 | 172419-87-3 | ethyl 4-[(4-fluorophenyl)methyl]morpholine-2-carboxylate |
| Mosapride Citrate-033 | 156816-54-5 | {4-[(4-fluorophenyl)methyl]morpholin-2-yl}methanol |
| Mosapride Citrate-022 | 85-41-6 | 1,3-Dihydro-1,3-dioxoisoindole |
| Mosapride Citrate-046 | 636582-78-0 | 2-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)-2,3-dihydro-1H-isoindole-1,3-dione |
| Mosapride Citrate-037 | 156334-90-6 | [(2R)-4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine |
| Mosapride Citrate-005 | 108282-38-8 | 4-Amino-5-chloro-2-ethoxybenzoic acid |
优化Route 8步骤 12 · 总收率 /
Mosapride Citrate-047152013-29-1Mosapride Citrate-048152013-28-0Mosapride Citrate-04924677-78-9Mosapride Citrate-050182067-51-2Mosapride Citrate-051182067-54-5Mosapride Citrate-052182067-60-3Mosapride Citrate-053793644-35-6Mosapride Citrate-054182068-19-5Mosapride Citrate-055182068-20-8Mosapride Citrate-056182068-21-9Mosapride Citrate-006112914-13-3Mosapride Citrate-057182068-07-1Mosapride Citrate-058182068-12-8Mosapride Citrate-059182068-15-1Mosapride Citrate-060182068-17-3API · 枸橼酸莫沙必利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Mosapride Citrate-047 | 152013-29-1 | 4-amino-5-chloro-2-ethoxy-3-hydroxy-N-[(5-oxomorpholin-2-yl)methyl]benzamide |
| Mosapride Citrate-048 | 152013-28-0 | 4-amino-5-chloro-2-ethoxy-3-hydroxy-N-(morpholin-2-ylmethyl)benzamide |
| Mosapride Citrate-049 | 24677-78-9 | 2,3-Dihydroxybenzaldehyde |
| Mosapride Citrate-050 | 182067-51-2 | 2-ethoxy-3-hydroxybenzaldehyde |
| Mosapride Citrate-051 | 182067-54-5 | 2-ethoxy-3-hydroxy-4-nitrobenzaldehyde |
| Mosapride Citrate-052 | 182067-60-3 | 2-ethoxy-3-hydroxy-4-nitrobenzoic acid |
| Mosapride Citrate-053 | 793644-35-6 | 6-(aminomethyl)morpholin-3-one |
| Mosapride Citrate-054 | 182068-19-5 | 2-ethoxy-3-hydroxy-4-nitro-N-[(5-oxomorpholin-2-yl)methyl]benzamide |
| Mosapride Citrate-055 | 182068-20-8 | 4-amino-2-ethoxy-3-hydroxy-N-[(5-oxomorpholin-2-yl)methyl]benzamide |
| Mosapride Citrate-056 | 182068-21-9 | 2-ethoxy-3-hydroxy-4-nitrobenzoyl chloride |
| Mosapride Citrate-006 | 112914-13-3 | [4-(4-Fluorobenzyl)-2-morpholinyl]methylamine |
| Mosapride Citrate-057 | 182068-07-1 | 2-ethoxy-N-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)-3-hydroxy-4-nitrobenzamide |
| Mosapride Citrate-058 | 182068-12-8 | tert-butyl 2-{[(2-ethoxy-3-hydroxy-4-nitrophenyl)formamido]methyl}morpholine-4-carboxylate |
| Mosapride Citrate-059 | 182068-15-1 | tert-butyl 2-{[(4-acetamido-2-ethoxy-3-hydroxyphenyl)formamido]methyl}morpholine-4-carboxylate |
| Mosapride Citrate-060 | 182068-17-3 | tert-butyl 2-{[(5-chloro-4-acetamido-2-ethoxy-3-hydroxyphenyl)formamido]methyl}morpholine-4-carboxylate |
优化Route 10步骤 4 · 总收率 53.87g(Mosapride Citrate-005)
Mosapride Citrate-005108282-38-8Mosapride Citrate-012133-10-8Mosapride Citrate-06422509-74-6Mosapride Citrate-06536467-52-4Mosapride Citrate-01474-96-4Mosapride Citrate-0662375033-34-2Mosapride Citrate-0672375033-38-6API · 枸橼酸莫沙必利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Mosapride Citrate-005 | 108282-38-8 | 4-Amino-5-chloro-2-ethoxybenzoic acid |
| Mosapride Citrate-012 | 133-10-8 | Sodium 4-amino-2-hydroxybenzoate |
| Mosapride Citrate-064 | 22509-74-6 | Ethyl 1,3-dioxo-2-isoindolinecarboxylate |
| Mosapride Citrate-065 | 36467-52-4 | 4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-hydroxybenzoic acid |
| Mosapride Citrate-014 | 74-96-4 | 1-Bromoethane |
| Mosapride Citrate-066 | 2375033-34-2 | Ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-ethoxybenzoate |
| Mosapride Citrate-067 | 2375033-38-6 | Ethyl 5-chloro-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-ethoxybenzoate |
优化Route 11步骤 6 · 总收率 54.6g(Mosapride Citrate (API))
Mosapride Citrate-068403-24-7Mosapride Citrate-069392-09-6Mosapride Citrate-070141-52-6Mosapride Citrate-07124091-87-0Mosapride Citrate-0722701758-99-6Mosapride Citrate-006112914-13-3Mosapride Citrate-007112885-41-3API · 枸橼酸莫沙必利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Mosapride Citrate-068 | 403-24-7 | 2-Fluoro-4-nitrobenzenecarboxylic acid |
| Mosapride Citrate-069 | 392-09-6在售 | Methyl 2-fluoro-4-nitrobenzenecarboxylate |
| Mosapride Citrate-070 | 141-52-6 | Ethanol sodium salt |
| Mosapride Citrate-071 | 24091-87-0 | Methyl 2-ethoxy-4-nitrobenzoate |
| Mosapride Citrate-072 | 2701758-99-6 | Methyl 5-chloro-2-ethoxy-4-nitrobenzoate |
| Mosapride Citrate-006 | 112914-13-3 | [4-(4-Fluorobenzyl)-2-morpholinyl]methylamine |
| Mosapride Citrate-007 | 112885-41-3 | - |
优化Route 12步骤 7 · 总收率 15.5g(Mosapride (Free))
Mosapride Citrate-07095-49-8Mosapride Citrate-071—Mosapride Citrate-072917-58-8Mosapride Citrate-0732486-63-7Mosapride Citrate-0742168687-91-8Mosapride Citrate-0752685871-36-5Mosapride Citrate-0762685871-37-6Mosapride Citrate-0772685871-38-7Mosapride Citrate-006112914-13-3Mosapride Citrate-007112885-41-3API · 枸橼酸莫沙必利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Mosapride Citrate-070 | 95-49-8 | 1-Chloro-2-methylbenzene |
| Mosapride Citrate-071 | - | 2-Chloro-1-methyl-4-nitrobenzene |
| Mosapride Citrate-072 | 917-58-8 | Potassium ethanolate |
| Mosapride Citrate-073 | 2486-63-7 | 2-Ethoxy-1-methyl-4-nitrobenzene |
| Mosapride Citrate-074 | 2168687-91-8 | 1-(Bromomethyl)-2-ethoxy-4-nitrobenzene |
| Mosapride Citrate-075 | 2685871-36-5 | 1-(Bromomethyl)-5-chloro-2-ethoxy-4-nitrobenzene |
| Mosapride Citrate-076 | 2685871-37-6 | 1-Chloro-4-ethoxy-5-(methoxymethyl)-2-nitrobenzene |
| Mosapride Citrate-077 | 2685871-38-7 | 2-Chloro-5-ethoxy-4-(methoxymethyl)aniline |
| Mosapride Citrate-006 | 112914-13-3 | [4-(4-Fluorobenzyl)-2-morpholinyl]methylamine |
| Mosapride Citrate-007 | 112885-41-3 | - |
工艺Route 9步骤 4 · 总收率 363g(Mosapride Citrate (API))
Mosapride Citrate-029116143-27-2Mosapride Citrate-005108282-38-8Mosapride Citrate-061152013-26-8Mosapride Citrate-0622170726-19-7Mosapride Citrate-030352-11-4Mosapride Citrate-063112885-34-4API · 枸橼酸莫沙必利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Mosapride Citrate-029 | 116143-27-2 | Morpholin-2-ylmethanamine |
| Mosapride Citrate-005 | 108282-38-8 | 4-Amino-5-chloro-2-ethoxybenzoic acid |
| Mosapride Citrate-061 | 152013-26-8 | 4-Amino-5-chloro-2-ethoxy-N-(morpholin-2-ylmethyl)benzamide |
| Mosapride Citrate-062 | 2170726-19-7 | 4-Acetamido-5-chloro-2-ethoxy-N-[(morpholin-2-yl)methyl]benzamide |
| Mosapride Citrate-030 | 352-11-4 | 1-(Chloromethyl)-4-fluorobenzene |
| Mosapride Citrate-063 | 112885-34-4 | 4-Acetamido-5-chloro-2-ethoxy-N-([4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl)benzamide |
常见问题（FAQ）
枸橼酸莫沙必利的适应症有哪些？
已批准的适应症包括：胃炎。
枸橼酸莫沙必利的专利什么时候到期？
枸橼酸莫沙必利的专利到期年暂无公开口径，本页会在数据管道核实后更新。
枸橼酸莫沙必利有几条合成路线？
本站收录 12 条合成路线，最短路线 4 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
枸橼酸莫沙必利的关键中间体在哪里可以采购？
枸橼酸莫沙必利的多条路线中间体已挂接 CAS 档案，其中 3 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取枸橼酸莫沙必利中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22