CAS 1802924-13-5

tert-butyl (4-fluoro-2-methoxy-5-nitrophenyl)carbamateN-Boc-4-Fluoro-2-methoxy-5-nitroaniline

登记编号：OSIM-015、(II) 920279-2-a

应用背景（按来源药适应症）

非小细胞肺癌甲磺酸奥希替尼非小细胞肺癌甲磺酸兰泽替尼肝功能衰退甲磺酸兰泽替尼

来源药（使用该中间体的合成路线）

品种	梯队	到期年
甲磺酸奥希替尼Osimertinib Mesylate	Tier A · 立即攻坚	2031
甲磺酸兰泽替尼Lazertinib Mesylate	Tier C · 观察 / 贸易	-

合成路线中的位置（上下游链）

按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。

甲磺酸奥希替尼优化路线步数：5总收率：190.5 mg

3-(2-chloropyrimidin-4-yl)-1-methyl-1H-indole→4-fluoro-2-methoxy-5-nitroaniline→N1,N1,N2-trimethylethane-1,2-diamine→acryloyl chloride→tert-butyl (4-fluoro-2-methoxy-5-nitrophenyl)carbamate→tert-butyl (4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxy-5-nitrophenyl)carbamate→tert-butyl (5-amino-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenyl)carbamate→N-(5-amino-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide

甲磺酸兰泽替尼优化路线步数：8总收率：/

2-Amino-5-fluoro-4-nitroanisole→N-Boc-4-Fluoro-2-methoxy-5-nitroaniline→1-Oxa-4-azacyclohexane→N-Boc-2-Methoxy-4-morpholin-4-yl-5-nitroaniline→tert-Butyl [5-amino-2-methoxy-4-(morpholin-4-yl)phenyl]carbamate→(Chloromethyl)acetyl chloride→tert-Butyl [5-(3-chloropropanamido)-2-methoxy-4-(morpholin-4-yl)phenyl]carbamate→N-(5-N-Boc-Amino-4-methoxy-2-morpholin-4-ylphenyl)acrylamide→N-[5-Amino-4-methoxy-2-(morpholin-4-yl)phenyl]prop-2-enamide→1-(2-Chloropyrimidin-4-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde→N-[5-[[4-(4-Formyl-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl]amino]-4-methoxy-2-(morpholin-4-yl)phenyl]prop-2-enamide→Dimethylamine hydrochloride→N-[5-[(4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl]prop-2-enamide

本站可供应的对应中间体

同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。

供应商	产品	价格区间	最小起订	货期	资质
Unibest Nantong cGMP Site	3-phenyl-1H-pyrazole-4-carbaldehyde Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	4-Chloro-2-(methylsulfonyl)pyrimidine Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	4-chloro-N-(2-methoxy-4-morpholino-5-nitrophenyl)pyrimidin-2-amine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	1-(2-((2-methoxy-4-morpholino-5-nitrophenyl)amino)pyrimidin-4-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)-N-(2-methoxy-4-morpholino-5-nitrophenyl)pyrimidin-2-amine Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	N1-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)-6-methoxy-4-morpholinobenzene-1,3-diamine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	4-fluoro-2-Methoxy-5-nitroaniline Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	3-(2-chloropyriMidin-4-yl)-1-Methylindole Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro- Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]benzene-1,2,4-triamine Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	N,N,N'-Trimethylethylenediamine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	N-(3-Chloropropyl)morpholine Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	5-hydroxy-4-methoxy-2-nitrobenzoic acid ethyl ester Pharmaceutical Intermediates	询价	询价	询价	—

本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。