← 返回专利悬崖列表
CAS 3934-20-1
2,4-dichloropyrimidine2-Chloropyrimidin-4-yl chloride
登记编号：OSIM-002、RILP-026、PAZO-006、(V)955428-1-a、PACR-011、(XIV) 920279-2-b、SULFA-002、MOME-001、(IV)1058685-1-a、SKI-O-703-001
应用背景（按来源药适应症）
非小细胞肺癌甲磺酸奥希替尼HIV感染盐酸利匹韦林肝功能衰退盐酸利匹韦林获得性免疫缺损综合征盐酸利匹韦林避孕行为盐酸利匹韦林肾细胞癌盐酸培唑帕尼肉瘤盐酸培唑帕尼软组织肿瘤盐酸培唑帕尼鼻出血盐酸培唑帕尼遗传性出血性毛细血管扩张盐酸培唑帕尼孤立性纤维性肿瘤盐酸培唑帕尼外周T细胞淋巴瘤戈利昔替尼EB病毒感染戈利昔替尼病毒感染戈利昔替尼组织细胞增生戈利昔替尼噬血细胞性淋巴组织细胞增多症戈利昔替尼间质性肺疾病戈利昔替尼骨髓纤维化枸橼酸帕克替尼血小板减少枸橼酸帕克替尼急性髓细胞样白血病枸橼酸帕克替尼原发性血小板增多症枸橼酸帕克替尼真性红细胞增多症枸橼酸帕克替尼慢性骨髓单核细胞性白血病枸橼酸帕克替尼非小细胞肺癌甲磺酸兰泽替尼肝功能衰退甲磺酸兰泽替尼神经内分泌瘤索凡替尼胰腺癌索凡替尼神经内分泌癌索凡替尼胰腺神经内分泌肿瘤索凡替尼肠道肿瘤索凡替尼阑尾肿瘤索凡替尼骨髓纤维化Momelotinib Dihydrochloride骨髓增生性疾病Momelotinib Dihydrochloride脾大Momelotinib Dihydrochloride贫血Momelotinib DihydrochlorideVEXAS综合征Momelotinib Dihydrochloride原发性血小板增多症Momelotinib Dihydrochloride非小细胞肺癌舒沃替尼B-细胞淋巴瘤舒沃替尼非霍奇金淋巴瘤舒沃替尼特发性血小板减少性紫癜Cevidoplenib类风湿关节炎Cevidoplenib
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 甲磺酸奥希替尼Osimertinib Mesylate | Tier A · 立即攻坚 | 2031 |
| 盐酸利匹韦林Rilpivirine Hydrochloride | Tier B · 提前布局 | - |
| 盐酸培唑帕尼Pazopanib Hydrochloride | Tier C · 观察 / 贸易 | - |
| 戈利昔替尼Golidocitinib | Tier C · 观察 / 贸易 | - |
| 枸橼酸帕克替尼Pacritinib Citrate | Tier C · 观察 / 贸易 | - |
| 甲磺酸兰泽替尼Lazertinib Mesylate | Tier C · 观察 / 贸易 | - |
| 索凡替尼Surufatinib | Tier C · 观察 / 贸易 | - |
| Momelotinib Dihydrochloride | Tier C · 观察 / 贸易 | - |
| 舒沃替尼Sunvozertinib | Tier C · 观察 / 贸易 | - |
| Cevidoplenib | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1H-indole→2,4-dichloropyrimidine→3-(2-chloropyrimidin-4-yl)-1H-indole→3-(2-chloropyrimidin-4-yl)-1-methyl-1H-indole→4-fluoro-2-methoxy-5-nitroaniline→N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine→N1,N1,N2-trimethylethane-1,2-diamine→N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine→N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine→acryloyl chloride→methanesulfonic acid
2,4-dichloropyrimidine→3-(2-chloropyrimidin-4-yl)-1-methyl-1H-indole→4-fluoro-2-methoxy-5-nitroaniline→N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine→N1,N1,N2-trimethylethane-1,2-diamine→N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine→N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine→methanesulfonic acid→1-methyl-1H-indole→3-chloropropanoyl chloride→3-chloro-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)propanamide
2-ethylaniline→2-ethyl-5-nitroaniline→3-methyl-6-nitro-1H-indazole→2,3-dimethyl-6-nitro-2H-indazole→2,3-dimethyl-2H-indazol-6-amine hydrochloride→2,4-dichloropyrimidine→N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine→N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine→5-amino-2-methylbenzenesulfonamide
7-Nitro-1H-indole→1-(4-Methylbenzene-1-sulfonyl)-7-nitro-1H-indole→3-Bromo-1-(4-methylbenzene-1-sulfonyl)-7-nitro-1H-indole→1-(4-Methylbenzene-1-sulfonyl)-7-nitro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole→2-Chloropyrimidin-4-yl chloride→3-(2-Chloro-4-pyrimidinyl)-N-tosyl-7-nitroindole→3-(2-Chloro-4-pyrimidinyl)-7-nitroindole→3-Methoxy-1-methyl-1H-pyrazol-4-amine hydrogen chloride (1/2)→N-(3-Methoxy-1-methyl-1H-pyrazol-4-yl)-4-(7-nitro-1H-indol-3-yl)pyrimidin-2-amine→3-[2-[(3-Methoxy-1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-amine→(2R)-2-(4-Methylpiperazin-1-yl)propanoic acid hydrogen chloride (1/2)→1-Methylpiperazine→(2S)-2-Hydroxypropanoic acid
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 3-phenyl-1H-pyrazole-4-carbaldehyde Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 4-Chloro-2-(methylsulfonyl)pyrimidine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 4-chloro-N-(2-methoxy-4-morpholino-5-nitrophenyl)pyrimidin-2-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 1-(2-((2-methoxy-4-morpholino-5-nitrophenyl)amino)pyrimidin-4-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)-N-(2-methoxy-4-morpholino-5-nitrophenyl)pyrimidin-2-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | N1-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)-6-methoxy-4-morpholinobenzene-1,3-diamine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 4-fluoro-2-Methoxy-5-nitroaniline Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 3-(2-chloropyriMidin-4-yl)-1-Methylindole Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro- Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]benzene-1,2,4-triamine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | N,N,N'-Trimethylethylenediamine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | N-(3-Chloropropyl)morpholine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 5-hydroxy-4-methoxy-2-nitrobenzoic acid ethyl ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 3-Methyl-6-nitroindazole Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 2,3-Dimethyl-2H-indazol-6-amine hydrochloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 3-Amino-6-methylbenzenesulfonamide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。